| Specific cleavage of IGFBP-4 by papp-a in nervous tissue. | Specific cleavage of IGFBP-4 by papp-a in nervous tissue.
Dya GA, Lebedeva OS, Gushchevarov DA, Volovikov EA, Belikova LD, Kopylova IV, Postnikov AB, Artemieva MM, Medvedeva NA, Lagarkova MA, Katrukha AG, Serebryanaya DV. | 10/16/2024 |
| AKAP12 and IGFBP4 Are Prognostic Factors for Chronic Lymphocytic Leukemia. | AKAP12 and IGFBP4 Are Prognostic Factors for Chronic Lymphocytic Leukemia.
Shi Y, Xu X, He Z, Tao H, Chen Y, Zhang L, Tao S, Ding B, Wang C, Yu L. | 01/4/2024 |
| Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy. | Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy.
AlMajed HT, Abu-Farha M, Alshawaf E, Devarajan S, Alsairafi Z, Elhelaly A, Cherian P, Al-Khairi I, Ali H, Jose RM, Thanaraj TA, Al-Ozairi E, Al-Mulla F, Al Attar A, Abubaker J., Free PMC Article | 09/29/2023 |
| The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4. | The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.
Chen W, Hu L, Lu X, Wang X, Zhao C, Guo C, Li X, Ding Y, Zhao H, Tong D, Wang L, Huang C., Free PMC Article | 08/30/2023 |
| m[6]A mRNA methylation regulates the ERK/NF-kappaB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer. | m(6)A mRNA methylation regulates the ERK/NF-κB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer.
Ruan P, Wang S, Yang C, Huang X, Sun P, Tan A. | 08/16/2023 |
| PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. | PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Adasheva DA, Lebedeva OS, Goliusova DV, Postnikov AB, Teriakova MV, Kopylova IV, Lagarkova MA, Katrukha AG, Serebryanaya DV., Free PMC Article | 05/22/2023 |
| Exosome-associated microRNA-375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection. | Exosome-associated microRNA-375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection.
Pradhan A, Shivaprasad S, Dey S, Goel A, Aggarwal R, Das S. | 11/26/2022 |
| Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians. | Functional characterization of a novel p.Ser76Thr variant in IGFBP4 that associates with body mass index in American Indians.
Muller YL, Saporito M, Day S, Bandesh K, Koroglu C, Kobes S, Knowler WC, Hanson RL, Regeneron Genetics Center, Van Hout CV, Shuldiner AR, Bogardus C, Baier LJ., Free PMC Article | 10/22/2022 |
| Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy. | Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy.
Jepsen MR, Østergaard JA, Conover CA, Wogensen L, Birn H, Krag SP, Fenton RA, Oxvig C. | 06/18/2022 |
| The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels. | The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels.
Alterki A, Al Shawaf E, Al-Khairi I, Cherian P, Sriraman D, Hammad M, Thanaraj TA, Ebrahim MAK, Al-Mulla F, Abu-Farha M, Abubaker J., Free PMC Article | 01/29/2022 |
| CT-IGFBP-4 as a novel prognostic biomarker in acute heart failure. | CT-IGFBP-4 as a novel prognostic biomarker in acute heart failure.
Konev AA, Kharitonov AV, Rozov FN, Altshuler EP, Serebryanaya DV, Lassus J, Harjola VP, Katrukha AG, Postnikov AB., Free PMC Article | 07/17/2021 |
| Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence. | Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence.
Alessio N, Squillaro T, Di Bernardo G, Galano G, De Rosa R, Melone MAB, Peluso G, Galderisi U., Free PMC Article | 03/27/2021 |
| IGFBP-4 released from glia-like human mesenchymal stem cells (ghMSCs) may serve as one of the key neuronal survival factors secreted from ghMSCs. | Glia-Like Cells from Late-Passage Human MSCs Protect Against Ischemic Stroke Through IGFBP-4.
Son JW, Park J, Kim YE, Ha J, Park DW, Chang MS, Koh SH. | 03/14/2020 |
| Birth weight and length Z-scores were negatively associated with Z-scores of intact IGFBP-4, PAPP-A, and PAPP-A2 levels | Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical cord blood and associations with birth weight and length.
DiPrisco B, Kumar A, Kalra B, Savjani GV, Michael Z, Farr O, Papathanasiou AE, Christou H, Mantzoros C. | 02/29/2020 |
| Results revealed that the differentially expressed IGFBP4 between aged and young samples is related to the process of aging. | Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey.
Wang H, Zhu X, Shen J, Zhao EF, He D, Shen H, Liu H, Zhou Y., Free PMC Article | 02/29/2020 |
| Igfbp4 down-regulation significantly correlated with EZH2 overexpression and poor survivals of HCC patients. IGFBP4 stimulated AKT/EZH2 phosphorylation to abrogate H3K27me3-mediated silencing, forming a reciprocal feedback loop that suppressed core transcription factor networks (FOXA1/HNF1A/HNF4A/KLF9/NR1H4) for normal liver homeostasis. | Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
Lee YY, Mok MT, Kang W, Yang W, Tang W, Wu F, Xu L, Yan M, Yu Z, Lee SD, Tong JHM, Cheung YS, Lai PBS, Yu DY, Wang Q, Wong GLH, Chan AM, Yip KY, To KF, Cheng ASL., Free PMC Article | 07/13/2019 |
| In STEMI patients, Stanniocalcin-2 and IGFBP-4 emerged as independent predictors of all-cause death and readmission due to HF. The Stanniocalcin-2/PAPP-A/IGFBP-4 axis exhibits a significant role in STEMI risk stratification. | Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction.
Cediel G, Rueda F, Oxvig C, Oliveras T, Labata C, de Diego O, Ferrer M, Aranda-Nevado MC, Serra-Gregori J, Núñez J, García C, Bayes-Genis A., Free PMC Article | 02/2/2019 |
| The authors also identified single-nucleotide polymorphisms in NRP2 and IGFBP4 loci that increase and reduce risk of lichen planus in hepatitis C virus-infected patients, respectively. | Genome-Wide Association Study Identifies Risk Variants for Lichen Planus in Patients With Hepatitis C Virus Infection.
Nagao Y, Nishida N, Toyo-Oka L, Kawaguchi A, Amoroso A, Carrozzo M, Sata M, Mizokami M, Tokunaga K, Tanaka Y. | 02/17/2018 |
| the results of this study raise the possibility that human mesenchymal stem cells actions involve a negative-regulatory mechanism that suppresses Treg proliferation by releasing IGFBP-4 | Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells.
Miyagawa I, Nakayamada S, Nakano K, Yamagata K, Sakata K, Yamaoka K, Tanaka Y. | 09/30/2017 |
| IGFBP-4 maybe act as a potential negative regulator in the progression of lung cancer through downregulation of COX-2. | Insulin-like growth factor binding protein-4 inhibits cell growth, migration and invasion, and downregulates COX-2 expression in A549 lung cancer cells.
Li W, Sun D, Lv Z, Wei Y, Zheng L, Zeng T, Zhao J. | 04/1/2017 |
| Patients with type 2 Diabetes Mellitus had lower serum concentrations of IGFBP-4 compared to controls. | The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.
Hjortebjerg R, Laugesen E, Høyem P, Oxvig C, Stausbøl-Grøn B, Knudsen ST, Kim WY, Poulsen PL, Hansen TK, Bjerre M, Frystyk J. | 03/18/2017 |
| Data show that insulin-like growth factor binding protein-4 (IGFBP-4) was significantly elevated in lupus nephritis, particularly those with renal pathology chronicity changes. | Insulin-Like Growth Factor Binding Protein-4 as a Marker of Chronic Lupus Nephritis.
Wu T, Xie C, Han J, Ye Y, Singh S, Zhou J, Li Y, Ding H, Li QZ, Zhou X, Putterman C, Saxena R, Mohan C., Free PMC Article | 08/13/2016 |
| The present study provides the first evidence that apoptosis inhibitor of macrophages binds to IGFBP2, 3 and 4. | Interaction of AIM with insulin-like growth factor-binding protein-4.
You Q, Wu Y, Yao N, Shen G, Zhang Y, Xu L, Li G, Ju C., Free PMC Article | 05/14/2016 |
| Data show that co-transfection with cDNA encoding stanniocalcin-1 abrogates the proteolytic activity of pregnancy-associated plasma protein-A (PAPP-A) toward IGF-binding protein 4 (IGFBP-4). | Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.
Kløverpris S, Mikkelsen JH, Pedersen JH, Jepsen MR, Laursen LS, Petersen SV, Oxvig C., Free PMC Article | 01/16/2016 |
| PLasma IGFBP-4 levels are not acutely altered following myocardial infarction treated with heparin and percutaneous coronary intervention. | PAPP-A and IGFBP-4 fragment levels in patients with ST-elevation myocardial infarction treated with heparin and PCI.
Hjortebjerg R, Lindberg S, Hoffmann S, Jensen JS, Oxvig C, Bjerre M, Frystyk J. | 01/16/2016 |