| The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study. | The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study.
Li W, She L, Zhang M, Yang M, Zheng W, He H, Wang P, Dai Q, Gong Z., Free PMC Article | 07/6/2024 |
| Dysfunction in IGF2R Pathway and Associated Perturbations in Autophagy and WNT Processes in Beckwith-Wiedemann Syndrome Cell Lines. | Dysfunction in IGF2R Pathway and Associated Perturbations in Autophagy and WNT Processes in Beckwith-Wiedemann Syndrome Cell Lines.
Pileggi S, Colombo EA, Ancona S, Quadri R, Bernardelli C, Colapietro P, Taiana M, Fontana L, Miozzo M, Lesma E, Sirchia SM., Free PMC Article | 04/17/2024 |
| CircTHBS1 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-136-3p/IGF2R axis. | CircTHBS1 promotes trophoblast cell migration and invasion and inhibits trophoblast apoptosis by regulating miR-136-3p/IGF2R axis.
Guo Y, Huang C, Qiu L, Fu J, Xu C, Yang F. | 04/10/2024 |
| AP-1gamma2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter. | AP-1γ2 is an adaptor protein 1 variant required for endosome-to-Golgi trafficking of the mannose-6-P receptor (CI-MPR) and ATP7B copper transporter.
Tavares LA, Rodrigues RL, Santos da Costa C, Nascimento JA, Vargas de Carvalho J, Nogueira de Carvalho A, Mardones GA, daSilva LLP., Free PMC Article | 04/10/2024 |
| Cation-independent mannose 6-phosphate receptor: From roles and functions to targeted therapies. | Cation-independent mannose 6-phosphate receptor: From roles and functions to targeted therapies.
Gauthier C, El Cheikh K, Basile I, Daurat M, Morère E, Garcia M, Maynadier M, Morère A, Gary-Bobo M. | 01/31/2024 |
| Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma. | Proteomics analysis of cancer tissues identifies IGF2R as a potential therapeutic target in laryngeal carcinoma.
Liu B, Hu Y, Wan L, Wang L, Cheng L, Sun H, Liu Y, Wu D, Zhu J, Hong X, Li Y, Zhou C., Free PMC Article | 11/12/2022 |
| Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport. | Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport.
Han J, Goldstein LA, Hou W, Watkins SC, Rabinowich H., Free PMC Article | 01/1/2022 |
| Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate. | Tissue plasminogen activator is a ligand of cation-independent mannose 6-phosphate receptor and consists of glycoforms that contain mannose 6-phosphate.
Miller JJ, Bohnsack RN, Olson LJ, Ishihara M, Aoki K, Tiemeyer M, Dahms NM., Free PMC Article | 12/4/2021 |
| IGF IIRalpha-triggered pathological manifestations in the heart aggravate renal inflammation in STZ-induced type-I diabetes rats. | IGF IIRα-triggered pathological manifestations in the heart aggravate renal inflammation in STZ-induced type-I diabetes rats.
Lin HC, Paul CR, Kuo CH, Chang YH, Chen WS, Ho TJ, Day CH, Viswanadha VP, Tsai Y, Huang CY., Free PMC Article | 08/7/2021 |
| The role of insulin-like growth factor in Acrochordon Etiopathology. | The role of insulin-like growth factor in Acrochordon Etiopathology.
Köseoğlu HG, Bozca BC, Başsorgun Cİ, Sarı R, Akbaş SH, Karakaş AA., Free PMC Article | 07/3/2021 |
| Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor. | Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor.
Olson LJ, Misra SK, Ishihara M, Battaile KP, Grant OC, Sood A, Woods RJ, Kim JP, Tiemeyer M, Ren G, Sharp JS, Dahms NM., Free PMC Article | 06/26/2021 |
| Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response. | Divergent Roles for Macrophage C-type Lectin Receptors, Dectin-1 and Mannose Receptors, in the Intestinal Inflammatory Response.
Rahabi M, Jacquemin G, Prat M, Meunier E, AlaEddine M, Bertrand B, Lefèvre L, Benmoussa K, Batigne P, Aubouy A, Auwerx J, Kirzin S, Bonnet D, Danjoux M, Pipy B, Alric L, Authier H, Coste A. | 03/27/2021 |
| Effect of prenatal bisphenol A exposure on early childhood body mass index through epigenetic influence on the insulin-like growth factor 2 receptor (IGF2R) gene. | Effect of prenatal bisphenol A exposure on early childhood body mass index through epigenetic influence on the insulin-like growth factor 2 receptor (IGF2R) gene.
Choi YJ, Lee YA, Hong YC, Cho J, Lee KS, Shin CH, Kim BN, Kim JI, Park SJ, Bisgaard H, Bønnelykke K, Lim YH. | 01/16/2021 |
| Expression, purification, and characterization of human mannose-6-phosphate receptor - Extra cellular domain from a stable cell line utilizing a small molecule biomimetic of the mannose-6-phosphate moiety. | Expression, purification, and characterization of human mannose-6-phosphate receptor - Extra cellular domain from a stable cell line utilizing a small molecule biomimetic of the mannose-6-phosphate moiety.
Dwyer B, Lundberg D, Iskenderian A, Strack-Logue B, Pescatore B, Norton AW, Xu J, Meiyappan M, Concino MF, Zhang B. | 01/9/2021 |
| GHR and IGF2R genes may contribute to normal variations in craniofacial dimensions: Insights from an admixed population. | GHR and IGF2R genes may contribute to normal variations in craniofacial dimensions: Insights from an admixed population.
Marañón-Vásquez GA, Vieira AR, de Carvalho Ramos AG, Dantas B, Romano FL, Palma-Dibb RG, Arid J, Carpio K, Nelson-Filho P, de Rossi A, Scariot R, Levy SC, Antunes LAA, Antunes LS, Küchler EC. | 11/21/2020 |
| Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins. | Upregulation of IGF2R evades lysosomal dysfunction-induced apoptosis of cervical cancer cells via transport of cathepsins.
Takeda T, Komatsu M, Chiwaki F, Komatsuzaki R, Nakamura K, Tsuji K, Kobayashi Y, Tominaga E, Ono M, Banno K, Aoki D, Sasaki H., Free PMC Article | 09/26/2020 |
| First study linking IGF2R placental expression with changes in the expression of homeobox genes that control cellular signalling pathways responsible for increased trophoblast cell apoptosis, which is a characteristic feature of Fetal growth restriction. | The role of insulin-like growth factor 2 receptor-mediated homeobox gene expression in human placental apoptosis, and its implications in idiopathic fetal growth restriction.
Harris LK, Pantham P, Yong HEJ, Pratt A, Borg AJ, Crocker I, Westwood M, Aplin J, Kalionis B, Murthi P. | 07/18/2020 |
| IGF2R played a tumor suppressor role in bladder cancer. Knockdown of IGF2R resulted in higher phosphorylation level of AKT. | Loss of IGF2R indicates a poor prognosis and promotes cell proliferation and tumorigenesis in bladder cancer via AKT signaling pathway.
Liu SB, Zhou LB, Wang HF, Li G, Xie QP, Hu B. | 03/14/2020 |
| The findings identify endoplasmic reticulum-transiting nascent IGF2R as an interaction partner of VKORC1v2 and target of viral IL-6 regulation and IGF2R as a positive contributor to HHV-8 biology, thereby extending understanding of the mechanisms of VKORC1v2-associated viral IL-6 function. | Insulin-Like Growth Factor 2 Receptor Expression Is Promoted by Human Herpesvirus 8-Encoded Interleukin-6 and Contributes to Viral Latency and Productive Replication.
Li Q, Chen D, Xiang Q, Nicholas J., Free PMC Article | 11/23/2019 |
| These results reveal an up-to-now undetermined function of M6P/IGF2R in clearance of apoptotic cells, which is crucial for tissue homeostasis. | The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis.
Ohradanova-Repic A, Machacek C, Donner C, Mühlgrabner V, Petrovčíková E, Zahradníková A Jr, Vičíková K, Hořejší V, Stockinger H, Leksa V., Free PMC Article | 10/19/2019 |
| mRNA levels of IGF2R were downregulated in hepatocellular carcinoma (HCC) compared with non-tumor tissue samples and was associated with a worse recurrencefree survival and a lower occurrence of cirrhosis. The IGF2R SNPs rs629849 and rs642588 were not significantly associated with HCC risk, whereas a homozygous IGF2R rs629849 GG genotype was associated with a significantly elevated risk of nonviral liver cirrhosis. | Expression and prognostic significance of insulin‑like growth factor-2 receptor in human hepatocellular carcinoma and the influence of transarterial chemoembolization.
Lautem A, Simon F, Hoppe-Lotichius M, Mittler J, Vollmar J, Schad A, Düber C, Galle PR, Otto G, Zimmermann T, Lang H. | 07/6/2019 |
| We found significantly elevated levels of soluble CD222 in sera of cancer patients compared to healthy controls irrespective of the type of disease. The urine CD222 levels were increased specifically in breast cancer and multiple myeloma. In contrast to serum, CD222 was present within CD222-positive exosomes in urine. | Serum and urinary levels of CD222 in cancer: origin and diagnostic value.
Vicikova K, Petrovcikova E, Manka P, Drach J, Stockinger H, Leksa V. | 07/6/2019 |
| experiments suggest that knockdown of circulating miR-143-3p may protect against insulin resistance in the setting of MetS via targeting of IGF2R and activation of the insulin signaling pathway | Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor.
Xihua L, Shengjie T, Weiwei G, Matro E, Tingting T, Lin L, Fang W, Jiaqiang Z, Fenping Z, Hong L. | 05/4/2019 |
| IGF-2R rs9456497 G genotype correlates to detrimental cardiovascular risks in ordinary population which might partially interpret their less preservation of health as compared to long-lived cohort. | Insulin-like factor-2 receptor rs9456497 G genotype overrepresents in males of average population and its correlation with cardiovascular risks.
Huang L, Peng JH, Liang QH, Yin RX, Liu CW, Pan SL, Huang H, Wu HY, Gan RJ, Tang LY, Zhu LN, Xu YZ, Chen SB, Zhou XL. | 03/23/2019 |
| M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by gamma Fc receptors, Grb2, and SHP-1. | M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRγ-Chain, Grb2, and SHP-1.
Rajaram MVS, Arnett E, Azad AK, Guirado E, Ni B, Gerberick AD, He LZ, Keler T, Thomas LJ, Lafuse WP, Schlesinger LS., Free PMC Article | 05/26/2018 |