| Functional cerebral asymmetries in the language domain are associated with the rs6733871 LRRTM1 polymorphism during cognitive control and top-down attention mechanisms. | Cognitive Control Processes and Functional Cerebral Asymmetries: Association with Variation in the Handedness-Associated Gene LRRTM1.
Beste C, Arning L, Gerding WM, Epplen JT, Mertins A, Röder MC, Bless JJ, Hugdahl K, Westerhausen R, Güntürkün O, Ocklenburg S. | 01/5/2019 |
| Continuity between schizophrenia and schizotypy exists with regard to the psychological effects of allelic variation in LRRTM1, and epigenetic variation in the imprinted gene mediates the development and expression of human handedness. | The imprinted gene LRRTM1 mediates schizotypy and handedness in a nonclinical population.
Leach EL, Prefontaine G, Hurd PL, Crespi BJ. | 07/25/2015 |
| Hypomethylation of the paternally inherited LRRTM1 promoter is linked to schizophrenia. | Hypomethylation of the paternally inherited LRRTM1 promoter linked to schizophrenia.
Brucato N, DeLisi LE, Fisher SE, Francks C. | 05/16/2015 |
| CTNNA1 and CTNNA2 contain alternative 5' exons linked to bidirectional promoters that are shared with the antisense oriented LRRTM2 and LRRTM1 genes, respectively. | Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms.
Kask M, Pruunsild P, Timmusk T. | 10/1/2011 |
| 16 SNPs in 12 genes showed significant interaction at P < .05, 3 of which survived correction for multiple testing (P < .0003), situated in AKT1 (rs2494732 and rs1130233) and LRRTM1 (rs673871). | Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.
van Winkel R, Genetic Risk and Outcome of Psychosis (GROUP) Investigators, van Winkel R, Genetic Risk and Outcome of Psychosis (GROUP) Investigators. | 03/26/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.
van Winkel R, Genetic Risk and Outcome of Psychosis (GROUP) Investigators, van Winkel R, Genetic Risk and Outcome of Psychosis (GROUP) Investigators. | 12/5/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Polymorphisms in leucine-rich repeat genes are associated with autism spectrum disorder susceptibility in populations of European ancestry.
Sousa I, Clark TG, Holt R, Pagnamenta AT, Mulder EJ, Minderaa RB, Bailey AJ, Battaglia A, Klauck SM, Poustka F, Monaco AP, International Molecular Genetic Study of Autism Consortium (IMGSAC)., Free PMC Article | 09/15/2010 |
| Results strengthen the evidence for an association of imprinted alleles of LRRTM1 with schizophrenia. Weaker supportive evidence was also obtained for a possible association of LRTTM1 with human brain asymmetry. | Supporting evidence for LRRTM1 imprinting effects in schizophrenia.
Ludwig KU, Mattheisen M, Mühleisen TW, Roeske D, Schmäl C, Breuer R, Schulte-Körne G, Müller-Myhsok B, Nöthen MM, Hoffmann P, Rietschel M, Cichon S. | 01/21/2010 |
| Recent study in which the first putative genetic effect on human handedness was identified (the imprinted locus LRRTM1 on human chromosome 2). | Understanding the genetics of behavioural and psychiatric traits will only be achieved through a realistic assessment of their complexity.
Francks C. | 01/21/2010 |
| While we agree (and indeed first proposed) that the variation underlying psychosis is intrinsically related to the cerebral torque, which we take to be the anatomical basis of language, we are unconvinced by the data for LRRTM1. | Where and what is the right shift factor or cerebral dominance gene? A critique of Francks et al. (2007).
Crow TJ, Close JP, Dagnall AM, Priddle TH. | 01/21/2010 |
| Whether or not LRRTM1 on chromosome 2p12 is indeed the genetic basis of handedness is still unclear, although the controversy of the claim seems indisputable. | Editorial commentary: is LRRTM1 the gene for handedness?
McManus C, Nicholls M, Vallortigara G. | 01/21/2010 |
| LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. | LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.
Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, Nicod J, Xiong L, Joober R, Enard W, Krinsky B, Nanba E, Richardson AJ, Riley BP, Martin NG, Strittmatter SM, Möller HJ, Rujescu D, St Clair D, Muglia P, Roos JL, Fisher SE, Wade-Martins R, Rouleau GA, Stein JF, Karayiorgou M, Geschwind DH, Ragoussis J, Kendler KS, Airaksinen MS, Oshimura M, DeLisi LE, Monaco AP., Free PMC Article | 01/21/2010 |