| Plasma immunoglobulin binding protein 1 as a predictor of development of lupus nephritis. | Plasma immunoglobulin binding protein 1 as a predictor of development of lupus nephritis.
Kwon OC, Lee EJ, Oh JS, Hong S, Lee CK, Yoo B, Park MC, Kim YG. | 03/13/2021 |
| Molecular profiling of thymoma with myasthenia gravis: Risk factors of developing myasthenia gravis in thymoma patients. | Molecular profiling of thymoma with myasthenia gravis: Risk factors of developing myasthenia gravis in thymoma patients.
Lee MC, Hsiao TH, Chuang HN, Lee LW, Chi PL, Tsai HM, Mao CL, Hsu CP. | 02/6/2021 |
| IGBP1 expression was increased in kidneys of lupus nephritis patients. Several genes related to lupus nephritis pathogenesis responded to siRNA-mediated IGBP1 silencing. | Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis.
Lee EJ, Kwon OC, Ghang B, Lim DH, Kim DH, Hong S, Lee CK, Yoo B, Kim YG., Free PMC Article | 11/16/2019 |
| Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c compared to expression levels of PP2Ac. | The three Type 2A protein phosphatases, PP2Ac, PP4c and PP6c, are differentially regulated by Alpha4.
LeNoue-Newton ML, Wadzinski BE, Spiller BW., Free PMC Article | 05/13/2017 |
| Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). | Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells.
Lee EJ, Park MK, Kim HJ, Kim EJ, Kang GJ, Byun HJ, Lee CH. | 07/30/2016 |
| MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac in X-linked Opitz syndrome. | MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.
Du H, Wu K, Didoronkute A, Levy MV, Todi N, Shchelokova A, Massiah MA., Free PMC Article | 04/2/2016 |
| alpha4 is an important regulatory molecule of apoptosis and Bcl-xL phosphorylation induced by BCR crosslinking. | Dominant negative form of alpha4 inhibits the BCR crosslinking-induced phosphorylation of Bcl-xL and apoptosis in an immature B cell line WEHI-231.
Tanabe K, Inui S. | 01/16/2016 |
| the alpha4 N-terminus binding to endogenous PP2Ac and PABP, and the C-terminus to EDD, is reported. | Progestin-inducible EDD E3 ubiquitin ligase binds to α4 phosphoprotein to regulate ubiquitination and degradation of protein phosphatase PP2Ac.
McDonald WJ, Thomas LN, Koirala S, Too CKL. | 08/30/2014 |
| A potential important role of alpha4 in control of cell migration and/or invasion via the regulation of E-cadherin expression in bladder urothelial carcinoma. | α4 contributes to bladder urothelial carcinoma cell invasion and/or metastasis via regulation of E-cadherin and is a predictor of outcome in bladder urothelial carcinoma patients.
Liu J, Cai M, Chen J, Liao Y, Mai S, Li Y, Huang X, Liu Y, Zhang J, Kung H, Zeng Y, Zhou F, Xie D. | 04/19/2014 |
| The structure of alpha45 reveals two distinct surfaces, one that can interact with a negatively charged surface, which is present on PP2A, and one that interacts with the Bbox1 domain of MID1. | NMR studies of the C-terminus of alpha4 reveal possible mechanism of its interaction with MID1 and protein phosphatase 2A.
Du H, Massiah MA., Free PMC Article | 09/1/2012 |
| alpha4 is highly expressed in carcinogen-transformed human cells and primary human cancers. | α4 is highly expressed in carcinogen-transformed human cells and primary human cancers.
Chen LP, Lai YD, Li DC, Zhu XN, Yang P, Li WX, Zhu W, Zhao J, Li XD, Xiao YM, Zhang Y, Xing XM, Wang Q, Zhang B, Lin YC, Zeng JL, Zhang SX, Liu CX, Li ZF, Zeng XW, Lin ZN, Zhuang ZX, Chen W. | 09/10/2011 |
| both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation. | The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation.
LeNoue-Newton M, Watkins GR, Zou P, Germane KL, McCorvey LR, Wadzinski BE, Spiller BW., Free PMC Article | 07/30/2011 |
| IGBP-1 is expressed universally in advanced lung adenocarcinomas, and its overexpression is significantly related to outcome. | Overexpression of immunoglobulin (CD79a) binding protein1 (IGBP-1) in small lung adenocarcinomas and its clinicopathological significance.
Sakashita S, Li D, Nashima N, Minami Y, Furuya S, Morishita Y, Tachibana K, Sato Y, Noguchi M. | 06/18/2011 |
| Data show that in addition to PP2Ac, alpha4 interacts with EDD and PABP, suggesting its involvement in multiple steps in the mTOR pathway that leads to translation initiation and cell-cycle progression. | alpha4 phosphoprotein interacts with EDD E3 ubiquitin ligase and poly(A)-binding protein.
McDonald WJ, Sangster SM, Moffat LD, Henderson MJ, Too CK. | 11/27/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| a new role for mTOR and alpha4/PP2Ac in the control of STAT1 nuclear content, and the expression of interferon-gamma-sensitive genes involved in immunity and apoptosis. | Inactivation of mammalian target of rapamycin increases STAT1 nuclear content and transcriptional activity in alpha4- and protein phosphatase 2A-dependent fashion.
Fielhaber JA, Han YS, Tan J, Xing S, Biggs CM, Joung KB, Kristof AS., Free PMC Article | 01/21/2010 |
| alpha4 C-terminal deletion mutants at 222 (alpha4Delta222), 236 (alpha4Delta236) & 254 (alpha4Delta254) were expressed. alpha4Delta222 & alpha4Delta236 possess a higher content of alpha-helix, indicating that C-terminal region is less structured. | Low resolution structure of the human alpha4 protein (IgBP1) and studies on the stability of alpha4 and of its yeast ortholog Tap42.
Smetana JH, Oliveira CL, Jablonka W, Aguiar Pertinhez T, Carneiro FR, Montero-Lomeli M, Torriani I, Zanchin NI. | 01/21/2010 |
| Alpha 4, a regulatory subunit of PP2-type phosphatases and a key component of the rapamycin-sensitive signaling pathway, has been indentified as a strong interactor of both MID1 and MID2. | MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders.
Short KM, Hopwood B, Yi Z, Cox TC., Free PMC Article | 01/21/2010 |