| Impact of IRGM gene promoter polymorphisms on susceptibility to chronic HBV infection. | Impact of IRGM gene promoter polymorphisms on susceptibility to chronic HBV infection.
Cheng H, Ouyang Y, Li C. | 06/3/2024 |
| IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma. | IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma.
Ru J, Lu J, Ge J, Ding B, Su R, Jiang Y, Sun Y, Ma J, Li Y, Sun J, Xu G, Tong R, Zheng S, Yang B, Wu J. | 12/21/2023 |
| TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM. | TAOK3 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance Through Augmenting Autophagy Mediated by IRGM.
Sun M, Li Z, Wang X, Zhao M, Chu Y, Zhang Z, Fang K, Zhao Z, Feng A, Leng Z, Shi J, Zhang L, Chen T, Xu M., Free PMC Article | 10/25/2023 |
| Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study. | Evaluation of Immunity-related GTPase Family M Protein (IRGM) SNPs among Egyptian Lupus Patients: A Case-control Study.
Ali AY, Medhat BM, Ashour SS, Badr AM, Dorgham D, Ramadan H, Behiry ME. | 09/1/2023 |
| Race-specific association of an IRGM risk allele with cytokine expression in human subjects. | Race-specific association of an IRGM risk allele with cytokine expression in human subjects.
Ajayi T, Rai P, Shi M, Gabor KA, Karmaus PWF, Meacham JM, Katen K, Madenspacher JH, Schurman SH, Fessler MB., Free PMC Article | 08/11/2023 |
| Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice. | Differential Requirement for IRGM Proteins during Tuberculosis Infection in Mice.
Wilburn KM, Meade RK, Heckenberg EM, Dockterman J, Coers J, Sassetti CM, Olive AJ, Smith CM., Free PMC Article | 03/8/2023 |
| IRGM/Irgm1 deficiency inhibits neutrophil-platelet interactions and thrombosis in experimental atherosclerosis and arterial injury. | IRGM/Irgm1 deficiency inhibits neutrophil-platelet interactions and thrombosis in experimental atherosclerosis and arterial injury.
Sun S, Zou X, Wang D, Liu Y, Zhang Z, Guo J, Lu R, Huang W, Wang S, Li Z, Tian J, Yu H, Fu J, Fang S. | 01/21/2023 |
| Association of IRGM promoter region polymorphisms and haplotype with pulmonary tuberculosis in Pakistani (Punjab) population. | Association of IRGM promoter region polymorphisms and haplotype with pulmonary tuberculosis in Pakistani (Punjab) population.
Zafar A, Shafiq M, Ali B, Sadee W, Shakoori AR, Shakoori FR. | 10/8/2022 |
| Association of IRGM gene promoter polymorphisms with hepatitis B virus infection. | Association of IRGM gene promoter polymorphisms with hepatitis B virus infection.
Sharma A, Duseja A, Parkash J, Changotra H. | 07/16/2022 |
| IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1 (+/-) mice display increases atherosclerotic plaque stability. | IRGM/Irgm1 facilitates macrophage apoptosis through ROS generation and MAPK signal transduction: Irgm1(+/-) mice display increases atherosclerotic plaque stability.
Fang S, Sun S, Cai H, Zou X, Wang S, Hao X, Wan X, Tian J, Li Z, He Z, Huang W, Liang C, Zhang Z, Yang L, Tian J, Yu B, Sun B., Free PMC Article | 02/12/2022 |
| Interferon-gamma activated T-cell IRGM-autophagy axis in oral lichen planus. | Interferon-γ activated T-cell IRGM-autophagy axis in oral lichen planus.
Tan YQ, Wang F, Ma RJ, Zhang J, Zhou G. | 06/12/2021 |
| IRGM promotes the PINK1-mediated mitophagy through the degradation of Mitofilin in SH-SY5Y cells. | IRGM promotes the PINK1-mediated mitophagy through the degradation of Mitofilin in SH-SY5Y cells.
Guo X, Zhang W, Wang C, Zhang B, Li R, Zhang L, Zhao K, Li Y, Tian L, Li B, Cheng H, Li L, Pei C, Xu H. | 05/1/2021 |
| The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study. | The immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study.
Simon TG, Deng X, Liu CT, Chung RT, Long MT., Free PMC Article | 09/26/2020 |
| Genetic polymorphisms of ATG16L1 and IRGM genes in Malaysian patients with Crohn's disease. | Genetic polymorphisms of ATG16L1 and IRGM genes in Malaysian patients with Crohn's disease.
Kee BP, Ng JG, Ng CC, Hilmi I, Goh KL, Chua KH. | 08/15/2020 |
| In addition to clinical risk factors, the rs13361189 single nucleotide polymorphism in the IRGM gene was independently associated with complications after ileocolectomy for Crohn's disease. | Clinical and Genetic Factors Associated With Complications After Crohn's Ileocolectomy.
Kline BP, Weaver T, Brinton DL Jr, Deiling S, Yochum GS, Berg AS, Koltun WA. | 07/18/2020 |
| show for the first time that subjects with risk alleles at two such loci, rs13361189 and rs10065172 , have reduced IRGM expression in whole blood and terminal ileum | Crohn's disease IRGM risk alleles are associated with altered gene expression in human tissues.
Ajayi TA, Innes CL, Grimm SA, Rai P, Finethy R, Coers J, Wang X, Bell DA, McGrath JA, Schurman SH, Fessler MB., Free PMC Article | 11/23/2019 |
| IRGM variants are associated with Nonalcoholic fatty liver disease. | IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn's Disease.
Simon TG, Van Der Sloot KWJ, Chin SB, Joshi AD, Lochhead P, Ananthakrishnan AN, Xavier R, Chung RT, Khalili H., Free PMC Article | 08/10/2019 |
| IRGM inhibits NLRP3 inflammasome activation to keep colonic inflammation under check. | The Crohn's Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy.
Mehto S, Jena KK, Nath P, Chauhan S, Kolapalli SP, Das SK, Sahoo PK, Jain A, Taylor GA, Chauhan S., Free PMC Article | 06/1/2019 |
| The glioma cells-derived IRGM could regulate IL-8 production and further M2 cells polarization through p62/TRAF6/NF-kappaB pathway and IRGM significantly influenced IL-8, MIP-3alpha, and IL-6 production, which is closely related to M2 macrophage polarization and recruitment. | IRGM promotes glioma M2 macrophage polarization through p62/TRAF6/NF-κB pathway mediated IL-8 production.
Xu Y, Liao C, Liu R, Liu J, Chen Z, Zhao H, Li Z, Chen L, Wu C, Tan H, Liu W, Li W. | 05/4/2019 |
| Stx17 directly interacts with IRGM, and efficient Stx17 recruitment to autophagosomes requires IRGM. Both IRGM and Stx17 directly interact with mammalian Atg8 proteins, thus being guided to autophagosomes. | Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.
Kumar S, Jain A, Farzam F, Jia J, Gu Y, Choi SW, Mudd MH, Claude-Taupin A, Wester MJ, Lidke KA, Rusten TE, Deretic V., Free PMC Article | 02/23/2019 |
| study reveals IRGM as a susceptibility gene of AITD and Graves' disease for the first time. | Polymorphisms in Autophagy-Related Gene IRGM Are Associated with Susceptibility to Autoimmune Thyroid Diseases.
Yao QM, Zhu YF, Wang W, Song ZY, Shao XQ, Li L, Song RH, An XF, Qin Q, Li Q, Zhang JA., Free PMC Article | 01/12/2019 |
| Findings suggest that ATP/GTP binding protein like 2 (AGBL2) plays a critical oncogenic role in the pathogenesis of hepatocellular carcinoma (HCC) through modulation on immunity-related GTPase family, M protein (IRGM)-regulated autophagy and aurora kinase A (Aurora A) activity. | AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma.
Wang LL, Jin XH, Cai MY, Li HG, Chen JW, Wang FW, Wang CY, Hu WW, Liu F, Xie D. | 10/27/2018 |
| The association of ATG16L1 to Crohn's disease in Iranian patients was confirmed while it was shown that the studied polymorphisms in IRGM was not associated with Crohn's disease. | Among autophagy genes, ATG16L1 but not IRGM is associated with Crohn's disease in Iranians.
Teimoori-Toolabi L, Samadpoor S, Mehrtash A, Ghadir M, Vahedi H. | 10/6/2018 |
| Four haplotypes showed a frequency of > 1%, among which the haplotype C-T-A-T-G was significantly associated with chronic periodontitis | A haplotypic variant at the IRGM locus and rs11747270 are related to the susceptibility for chronic periodontitis.
Folwaczny M, Tsekeri E, Glas J. | 08/25/2018 |
| HCV triggers IRGM-mediated phosphorylation of the early autophagy initiator ULK1, thereby providing mechanistic insight into the role of IRGM in HCV-mediated autophagy. | Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.
Hansen MD, Johnsen IB, Stiberg KA, Sherstova T, Wakita T, Richard GM, Kandasamy RK, Meurs EF, Anthonsen MW., Free PMC Article | 04/28/2018 |