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    IFNAR1 interferon alpha and beta receptor subunit 1 [ Homo sapiens (human) ]

    Gene ID: 3454, updated on 19-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Detection of interferon alpha and beta receptor subunit 1 (IFNAR1) loss-of-function Glu386 * variant by tri-allelic genotyping.

    Detection of interferon alpha and beta receptor subunit 1 (IFNAR1) loss-of-function Glu386∗ variant by tri-allelic genotyping.
    Woon ST, Tjandra F, Mackay J, Lumley T, Grainger P, Wood A, Hsiao KC, Ameratunga R.

    02/2/2024
    Association of IFNAR1 and IFNAR2 with COVID-19 severity.

    Association of IFNAR1 and IFNAR2 with COVID-19 severity.
    Yaugel-Novoa M, Bourlet T, Longet S, Botelho-Nevers E, Paul S., Free PMC Article

    07/23/2023
    CK1alpha upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.

    CK1α upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells.
    Xiong J, Jiang Y, Zhang J, Chen Y, Hu Y., Free PMC Article

    12/24/2022
    Correlation between IFNAR1 expression in peripheral blood T lymphocytes and inflammatory cytokines, tumor-infiltrating lymphocytes, and chemosensitivity in patients with colorectal cancer.

    Correlation between IFNAR1 expression in peripheral blood T lymphocytes and inflammatory cytokines, tumor-infiltrating lymphocytes, and chemosensitivity in patients with colorectal cancer.
    Yang L, Zhang X, Huang X, Dong X, Jing S, Zhang Y, Zhao B, Wang Z, Qu H.

    10/1/2022
    Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression.

    Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression.
    C West R, Ezashi T, B Schoolcraft W, Yuan Y.

    08/20/2022
    A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes.

    A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes.
    Bastard P, Hsiao KC, Zhang Q, Choin J, Best E, Chen J, Gervais A, Bizien L, Materna M, Harmant C, Roux M, Hawley NL, Weeks DE, McGarvey ST, Sandoval K, Barberena-Jonas C, Quinto-Cortés CD, Hagelberg E, Mentzer AJ, Robson K, Coulibaly B, Seeleuthner Y, Bigio B, Li Z, Uzé G, Pellegrini S, Lorenzo L, Sbihi Z, Latour S, Besnard M, Adam de Beaumais T, Jacqz Aigrain E, Béziat V, Deka R, Esera Tulifau L, Viali S, Reupena MS, Naseri T, McNaughton P, Sarkozy V, Peake J, Blincoe A, Primhak S, Stables S, Gibson K, Woon ST, Drake KM, Hill AVS, Chan CY, King R, Ameratunga R, Teiti I, Aubry M, Cao-Lormeau VM, Tangye SG, Zhang SY, Jouanguy E, Gray P, Abel L, Moreno-Estrada A, Minster RL, Quintana-Murci L, Wood AC, Casanova JL., Free PMC Article

    07/23/2022
    Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.

    Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.
    Zhang Q, Matuozzo D, Le Pen J, Lee D, Moens L, Asano T, Bohlen J, Liu Z, Moncada-Velez M, Kendir-Demirkol Y, Jing H, Bizien L, Marchal A, Abolhassani H, Delafontaine S, Bucciol G, COVID Human Genetic Effort, Bayhan GI, Keles S, Kiykim A, Hancerli S, Haerynck F, Florkin B, Hatipoglu N, Ozcelik T, Morelle G, Zatz M, Ng LFP, Lye DC, Young BE, Leo YS, Dalgard CL, Lifton RP, Renia L, Meyts I, Jouanguy E, Hammarström L, Pan-Hammarström Q, Boisson B, Bastard P, Su HC, Boisson-Dupuis S, Abel L, Rice CM, Zhang SY, Cobat A, Casanova JL., Free PMC Article

    06/25/2022
    Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis.

    Ifnar gene variants influence gut microbial production of palmitoleic acid and host immune responses to tuberculosis.
    Chen L, Zhang G, Li G, Wang W, Ge Z, Yang Y, He X, Liu Z, Zhang Z, Mai Q, Chen Y, Chen Z, Pi J, Yang S, Cui J, Liu H, Shen L, Zeng L, Zhou L, Chen X, Ge B, Chen ZW, Zeng G.

    04/30/2022
    Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients.

    Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients.
    Akbari M, Akhavan-Bahabadi M, Shafigh N, Taheriazam A, Hussen BM, Sayad A, Fathi M, Taheri M, Ghafouri-Fard S, Fathi M., Free PMC Article

    04/23/2022
    A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19.

    A Case of Autosomal Recessive Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency with Severe COVID-19.
    Khanmohammadi S, Rezaei N, Khazaei M, Shirkani A., Free PMC Article

    02/19/2022
    Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1.

    Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1.
    Azamor T, Cunha DP, da Silva AMV, Bezerra OCL, Ribeiro-Alves M, Calvo TL, Kehdy FSG, Manta FSN, Pinto TGT, Ferreira LP, Portari EA, Guida LDC, Gomes L, Moreira MEL, de Carvalho EF, Cardoso CC, Muller M, Ano Bom APD, Neves PCDC, Vasconcelos Z, Moraes MO., Free PMC Article

    02/12/2022
    ZBTB28 inhibits breast cancer by activating IFNAR and dual blocking CD24 and CD47 to enhance macrophages phagocytosis.

    ZBTB28 inhibits breast cancer by activating IFNAR and dual blocking CD24 and CD47 to enhance macrophages phagocytosis.
    Li L, Gong Y, Tang J, Yan C, Li L, Peng W, Cheng Z, Yu R, Xiang Q, Deng C, Mu J, Xia J, Luo X, Wu Y, Xiang T., Free PMC Article

    01/29/2022
    IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs.

    IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs.
    Shemesh M, Lochte S, Piehler J, Schreiber G.

    01/29/2022
    Association study of promoter polymorphisms of interferon alpha and beta receptor subunit 1 (IFNAR1) gene and therapeutic response to interferon-beta in patients with multiple sclerosis.

    Association study of promoter polymorphisms of interferon alpha and beta receptor subunit 1 (IFNAR1) gene and therapeutic response to interferon-beta in patients with multiple sclerosis.
    Hajian S, Mazdeh M, Nouri F, Roshanaei G, Soleimani M.

    01/29/2022
    IFNAR1 gene mutation may contribute to developmental stuttering in the Chinese population.

    IFNAR1 gene mutation may contribute to developmental stuttering in the Chinese population.
    Sun Y, Gao Y, Zhou Y, Zhou Y, Zhang Y, Wang D, Tan LH., Free PMC Article

    01/22/2022
    TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction.

    TRIM10 binds to IFN-α/β receptor 1 to negatively regulate type I IFN signal transduction.
    Guo M, Cao W, Chen S, Tian R, Wang L, Liu Q, Zhang L, Wang Z, Zhao M, Lu Q, Zhu H.

    10/2/2021
    Human Cytomegalovirus miR-US33as-5p Targets IFNAR1 to Achieve Immune Evasion During Both Lytic and Latent Infection.

    Human Cytomegalovirus miR-US33as-5p Targets IFNAR1 to Achieve Immune Evasion During Both Lytic and Latent Infection.
    Zhang Q, Song X, Ma P, Lv L, Zhang Y, Deng J, Zhang Y., Free PMC Article

    09/18/2021
    Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency.

    Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiency.
    Bastard P, Manry J, Chen J, Rosain J, Seeleuthner Y, AbuZaitun O, Lorenzo L, Khan T, Hasek M, Hernandez N, Bigio B, Zhang P, Lévy R, Shrot S, Reino EJG, Lee YS, Boucherit S, Aubart M, Gijsbers R, Béziat V, Li Z, Pellegrini S, Rozenberg F, Marr N, Meyts I, Boisson B, Cobat A, Bustamante J, Zhang Q, Jouangy E, Abel L, Somech R, Casanova JL, Zhang SY., Free PMC Article

    09/11/2021
    MicroRNA-29s suppressed both soluble ST2 release and IFNAR1 expression in human bronchial epithelial cells.

    MicroRNA-29s suppressed both soluble ST2 release and IFNAR1 expression in human bronchial epithelial cells.
    Igarashi A, Matsumoto K, Matsuda A.

    08/21/2021
    Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction.

    Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction.
    Iaconis G, Jackson B, Childs K, Boyce M, Goodbourn S, Blake N, Iturriza-Gomara M, Seago J., Free PMC Article

    08/14/2021
    MicroRNA-93-5p/IFNAR1 axis accelerates metastasis of endometrial carcinoma by activating the STAT3 pathway.

    MicroRNA-93-5p/IFNAR1 axis accelerates metastasis of endometrial carcinoma by activating the STAT3 pathway.
    Xu JB.

    10/3/2020
    Cellular Caspase-3 Contributes to EV-A71 2A(pro)-Mediated Down-Regulation of IFNAR1 at the Translation Level.

    Cellular Caspase-3 Contributes to EV-A71 2A(pro)-Mediated Down-Regulation of IFNAR1 at the Translation Level.
    Chen B, Wang Y, Pei X, Wang S, Zhang H, Peng Y., Free PMC Article

    10/3/2020
    complete IFNAR1 deficiency can result in life-threatening complications of vaccination with live attenuated measles and Yellow fever viruses in previously healthy individuals.

    Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines.
    Hernandez N, Bucciol G, Moens L, Le Pen J, Shahrooei M, Goudouris E, Shirkani A, Changi-Ashtiani M, Rokni-Zadeh H, Sayar EH, Reisli I, Lefevre-Utile A, Zijlmans D, Jurado A, Pholien R, Drutman S, Belkaya S, Cobat A, Boudewijns R, Jochmans D, Neyts J, Seeleuthner Y, Lorenzo-Diaz L, Enemchukwu C, Tietjen I, Hoffmann HH, Momenilandi M, Pöyhönen L, Siqueira MM, de Lima SMB, de Souza Matos DC, Homma A, Maia MLS, da Costa Barros TA, de Oliveira PMN, Mesquita EC, Gijsbers R, Zhang SY, Seligman SJ, Abel L, Hertzog P, Marr N, Martins RM, Meyts I, Zhang Q, MacDonald MR, Rice CM, Casanova JL, Jouanguy E, Bossuyt X., Free PMC Article

    06/13/2020
    Overexpression of IFNAR1, MX1 and signal transducer and activator of transcription 1 (Stat1) indicated the endogenous IFNa activation in tumour microenvironment, which correlated with immunosuppression status in head and neck squamous cell carcinomas (HNSCC) patients

    Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma.
    Ma H, Yang W, Zhang L, Liu S, Zhao M, Zhou G, Wang L, Jin S, Zhang Z, Hu J., Free PMC Article

    11/16/2019
    results indicated that the IFNAR promoter methylation might have a potential relationship with the status of oxidative stress

    Decreased Methylation of IFNAR Gene Promoter from Peripheral Blood Mononuclear Cells Is Associated with Oxidative Stress in Chronic Hepatitis B.
    Wang JW, Wang JW, Zhang J, Wu CS, Fang Y, Su WW, Fan YC, Wang K.

    10/26/2019
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