| IFP35 family proteins promote neuroinflammation and multiple sclerosis. | IFP35 family proteins promote neuroinflammation and multiple sclerosis.
Jing X, Yao Y, Wu D, Hong H, Feng X, Xu N, Liu Y, Liang H., Free PMC Article | 12/18/2021 |
| IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis. | IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.
De Masi R, Orlando S. | 11/21/2020 |
| inhibits both endothelial cell proliferation and migration by inhibiting the NF-kappaB/p65 pathway; functionally interacts with Nmi through its NID1 domain | Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.
Jian D, Wang W, Zhou X, Jia Z, Wang J, Yang M, Zhao W, Jiang Z, Hu X, Zhu J. | 09/21/2019 |
| IFI35 enhances proliferation of mesangial cells and is regulated by MBD2 in lupus nephritis. | The role of IFI35 in lupus nephritis and related mechanisms.
Zhang L, Zhu H, Li Y, Dai X, Zhou B, Li Q, Zuo X, Luo H. | 05/26/2018 |
| Damage-associated molecular patterns (DAMP) are important mediators of innate immunity. Here the authors show that N-myc and STAT interactor (NMI) and interferon-induced protein 35 (IFP35) act as DAMPs to promote inflammation by activating macrophages via the Toll-like receptor 4 and NF-kappaB pathways. | NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.
Xiahou Z, Wang X, Shen J, Zhu X, Xu F, Hu R, Guo D, Li H, Tian Y, Liu Y, Liang H., Free PMC Article | 02/17/2018 |
| Study found that TLR3 signaling induces the expression of IFI35, and IFI35 negatively regulates IFN-beta-P-STAT1-RIG-I-CXCL10/CCL5 axis in U373MG cells. This suggests that IFI35 expressed in astrocytes may play an important role in regulating the innate immune system in astrocytoma cells. | Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.
Shirai K, Shimada T, Yoshida H, Hayakari R, Matsumiya T, Tanji K, Murakami M, Tanaka H, Imaizumi T. | 08/12/2017 |
| Activation of TLR3 by poly IC induces the IFI35 expression in Mesangial Cells. Regional expression of IFI35 and its dysregulation may be involved in the pathogenesis of glomerular inflammation in CKD. | Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.
Imaizumi T, Yano C, Numata A, Tsugawa K, Hayakari R, Matsumiya T, Yoshida H, Watanabe S, Tsuruga K, Kawaguchi S, Murakami M, Tanaka H. | 04/8/2017 |
| Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response | Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.
Das A, Dinh PX, Pattnaik AK. | 02/6/2016 |
| Knockdown of IFP35 expression abolished pEGFP-N1-2C and pEGFP-N1-Nmi-induced activation of type I interferon promoters. | A critical role of interferon-induced protein IFP35 in the type I interferon response in cells induced by foot-and-mouth disease virus (FMDV) protein 2C.
Zheng W, Li X, Wang J, Li X, Cao H, Wang Y, Zeng Q, Zheng SJ. | 12/27/2014 |
| IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication. | Interferon-inducible protein IFI35 negatively regulates RIG-I antiviral signaling and supports vesicular stomatitis virus replication.
Das A, Dinh PX, Panda D, Pattnaik AK., Free PMC Article | 05/17/2014 |
| IRF-1 also activates IFP35 expression in an IFN-gamma-inducible manner. | Interferon-γ upregulates expression of IFP35 gene in HeLa cells via interferon regulatory factor-1.
Yang W, Tan J, Liu R, Cui X, Ma Q, Geng Y, Qiao W., Free PMC Article | 05/25/2013 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, Ovarian Cancer Association Consortium, Australian Ovarian Cancer Study Group, Australian Cancer Study (Ovarian Cancer)., Free PMC Article | 09/15/2010 |
| IFP35 can interact with the bovine Tas (BTas) regulatory protein of bovine foamy virus; overexpression of IFP35 disturbs the ability of BTas to activate viral-gene transcription and inhibits viral replication. | IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus.
Tan J, Qiao W, Wang J, Xu F, Li Y, Zhou J, Chen Q, Geng Y., Free PMC Article | 01/21/2010 |
| Dissociation of the IFN-induced protein IFP35 from NMI is a newly defined specific cytoplasmic event occurring during apoptosis. | Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells.
Chen J, Naumovski L. | 01/21/2010 |
| The results provide a novel role of CKIP-1 in cytokine signaling response and the biochemical mechanism, by which two previously identified modulators IFP35 and Nmi are involved via interactions. | The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling.
Zhang L, Tang Y, Tie Y, Tian C, Wang J, Dong Y, Sun Z, He F. | 01/21/2010 |