| Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease. | Intracellular autoactivation of TMPRSS11A, an airway epithelial transmembrane serine protease.
Zhang C, Zhang Y, Zhang S, Wang Z, Sun S, Liu M, Chen Y, Dong N, Wu Q., Free PMC Article | 09/19/2020 |
| show that TMPRSS11A, another member of the TTSP family, cleaves and activates the influenza A virus (FLUAV) HA and the Middle East respiratory syndrome coronavirus spike protein (MERS-S). | TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1.
Zmora P, Hoffmann M, Kollmus H, Moldenhauer AS, Danov O, Braun A, Winkler M, Schughart K, Pöhlmann S., Free PMC Article | 03/2/2019 |
| ECRG1 Arg290Gln polymorphism significantly affects the susceptibility but not the prognosis of esophageal squamous cell carcinoma patients in low-risk north Indian population. | Modification of risk, but not survival of esophageal cancer patients by esophageal cancer-related gene 1 Arg290Gln polymorphism: a case-control study and meta-analysis.
Umar M, Upadhyay R, Kumar S, Ghoshal UC, Mittal B. | 05/17/2014 |
| This suggests that substitution of the arginine in the conserved catalytic domain of the ECRG1 protein might reduce its catalytic capacity by impacting its 3-dimensional conformation, thereby causing the genetic susceptibility to ESCC. [review] | ECRG1 and its relationship with esophageal cancer: a brief review.
Rasool S, Khan T, Qazi F, Ganai BA. | 10/19/2013 |
| Data show that the allele types of ECRG1 were Arg/Arg (54.2%), Arg/Gln (45.8%) and Gln/Gln (0.00%), and the allele types of FGFR4 amino acid 388 were Arg/Arg (8.3%), Arg/Gly (54.2%) and Gly/Gly (37.5%). | ECRG1 and FGFR4 single nucleotide polymorphism as predictive factors for nodal metastasis in oral squamous cell carcinoma.
Choi KY, Rho YS, Kwon KH, Chung EJ, Kim JH, Park IS, Lee DJ. | 08/31/2013 |
| A statistically significantly increased risk of ESCC was found to be associated with the ECRG1 Arg/Gln and Gln/Gln genotype. | The ECRG1 290Arg/Gln polymorphism is related to risk of esophageal squamous cell carcinoma in Kashmir.
Rasool S, Ganai BA, Kadla SA, Ahanger AG, Qazi F, Khan T, Rasool V, Masood A. | 06/2/2012 |
| Data show that ECRG4 interacts directly with ECRG1 to upregulate p21 protein expression, induce cell cycle G1 phase block and inhibit cancer cells proliferation in ESCC. | A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma.
Li LW, Li YY, Li XY, Zhang CP, Zhou Y, Lu SH., Free PMC Article | 05/28/2011 |
| no significant association between single nucleotide polymorphisms Arg/Arg, Arg/Gln and Gln/Gln and survival in oral squamous cell carcinoma | Single nucleotide polymorphism in esophageal cancer related gene 1: an analysis in resected oral squamous cell carcinoma patients.
Blessmann M, Pohlenz P, Atac A, Kaifi JT, Eulenburg C, Kalinin V, Merkert P, Smeets R, Heiland M, Blake F, Schmelzle R, Izbicki JR, Blessmann M, Pohlenz P, Atac A, Kaifi JT, Eulenburg C, Kalinin V, Merkert P, Smeets R, Heiland M, Blake F, Schmelzle R, Izbicki JR. | 01/21/2010 |
| DNA polymorphisms in the coding region of ECRG1 are associated with poor outcome after surgical resection in esophageal carcinoma. | Polymorphism Arg290Arg in esophageal-cancer-related gene 1 (ECRG1) is a prognostic factor for survival in esophageal cancer.
Bachmann K, Shahmiri S, Kaifi J, Schurr P, Mann O, Rawnaq T, Block S, Kalinin V, Izbicki JR, Strate T, Bachmann K, Shahmiri S, Kaifi J, Schurr P, Mann O, Rawnaq T, Block S, Kalinin V, Izbicki JR, Strate T. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesCandidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.
Akbari MR, Malekzadeh R, Shakeri R, Nasrollahzadeh D, Foumani M, Sun Y, Pourshams A, Sadjadi A, Jafari E, Sotoudeh M, Kamangar F, Boffetta P, Dawsey SM, Ghadirian P, Narod SA. Single nucleotide polymorphism in esophageal cancer related gene 1: an analysis in resected oral squamous cell carcinoma patients.
Blessmann M, Pohlenz P, Atac A, Kaifi JT, Eulenburg C, Kalinin V, Merkert P, Smeets R, Heiland M, Blake F, Schmelzle R, Izbicki JR, Blessmann M, Pohlenz P, Atac A, Kaifi JT, Eulenburg C, Kalinin V, Merkert P, Smeets R, Heiland M, Blake F, Schmelzle R, Izbicki JR. Polymorphism Arg290Arg in esophageal-cancer-related gene 1 (ECRG1) is a prognostic factor for survival in esophageal cancer.
Bachmann K, Shahmiri S, Kaifi J, Schurr P, Mann O, Rawnaq T, Block S, Kalinin V, Izbicki JR, Strate T, Bachmann K, Shahmiri S, Kaifi J, Schurr P, Mann O, Rawnaq T, Block S, Kalinin V, Izbicki JR, Strate T. | 01/11/2009 |
| findings indicate that ECRG1 may be a candidate tumor suppressor gene for esophageal cancer involved in cell-cycle control | ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors.
Yueying W, Jianbo W, Hailin L, Huaijing T, Liping G, Shih-Hsin L. | 01/21/2010 |