| Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity. | Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity.
Wang S, Kim K, Gelvez N, Chung C, Gout JF, Fixman B, Vermulst M, Chen XS., | 05/28/2024 |
| APOBEC mutagenesis is a common process in normal human small intestine. | APOBEC mutagenesis is a common process in normal human small intestine.
Wang Y, Robinson PS, Coorens THH, Moore L, Lee-Six H, Noorani A, Sanders MA, Jung H, Katainen R, Heuschkel R, Brunton-Sim R, Weston R, Read D, Nobbs B, Fitzgerald RC, Saeb-Parsy K, Martincorena I, Campbell PJ, Rushbrook S, Zilbauer M, Buczacki SJA, Stratton MR., Free PMC Article | 02/22/2023 |
| The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness. | The roles of APOBEC-mediated RNA editing in SARS-CoV-2 mutations, replication and fitness.
Kim K, Calabrese P, Wang S, Qin C, Rao Y, Feng P, Chen XS., Free PMC Article | 10/22/2022 |
| Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences. | Harnessing A3G for efficient and selective C-to-T conversion at C-rich sequences.
Yu W, Li J, Huang S, Li X, Li P, Li G, Liang A, Chi T, Huang X., Free PMC Article | 10/2/2021 |
| APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A. | APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.
Wong L, Vizeacoumar FS, Vizeacoumar FJ, Chelico L., Free PMC Article | 01/23/2021 |
| Our findings propose APOBEC1 and isoform b as the potential endogenous mutators implicated in cancer in-frame indels and pave the way for their use as novel prognostic tumor markers. | Pancancer analysis identifies prognostic high-APOBEC1 expression level implicated in cancer in-frame insertions and deletions.
Niavarani A, Shahrabi Farahani A, Sharafkhah M, Rassoulzadegan M. | 11/3/2018 |
| Luciferase-fused 3' untranslated region of human Dickkopf1 activity was highly upregulated in A1CF-overexpressed MCF7 cells, but this upregulation can be inhibited by mutating conserved binding motifs of Dickkopf1 3' untranslated region. A1CF played a crucial role in cell migration and survival through affecting 3' untranslated region of Dickkopf1 to upregulate its expression in MCF7 cells. | Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3' untranslated region in MCF7 cells.
Yan X, Li Q, Ni D, Xie Y, He Q, Wan Q, Liu Y, Lyu Z, Mao Z, Zhou Q. | 07/15/2017 |
| AICDA/APOBEC family of cytidine deaminases is significant in innate immunity, as it restricts numerous viruses, including HBV, through hypermutationdependent and independent mechanisms. (Review) | Associations between activation-induced cytidine deaminase/apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like cytidine deaminase expression, hepatitis B virus (HBV) replication and HBV-associated liver disease (Review).
He X, Li J, Wu J, Zhang M, Gao P., Free PMC Article | 08/13/2016 |
| Results show that expression of APOBEC1 induces a mutator phenotype in 2 different cellular models. | The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.
Saraconi G, Severi F, Sala C, Mattiuz G, Conticello SG., Free PMC Article | 06/20/2015 |
| An APOBEC-mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in esophageal squamous cell carcinoma. | Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.
Zhang L, Zhou Y, Cheng C, Cui H, Cheng L, Kong P, Wang J, Li Y, Chen W, Song B, Wang F, Jia Z, Li L, Li Y, Yang B, Liu J, Shi R, Bi Y, Zhang Y, Wang J, Zhao Z, Hu X, Yang J, Li H, Gao Z, Chen G, Huang X, Yang X, Wan S, Chen C, Li B, Tan Y, Chen L, He M, Xie S, Li X, Zhuang X, Wang M, Xia Z, Luo L, Ma J, Dong B, Zhao J, Song Y, Ou Y, Li E, Xu L, Wang J, Xi Y, Li G, Xu E, Liang J, Yang X, Guo J, Chen X, Zhang Y, Li Q, Liu L, Li Y, Zhang X, Yang H, Lin D, Cheng X, Guo Y, Wang J, Zhan Q, Cui Y., Free PMC Article | 05/30/2015 |
| hnRNPQ6 is required for APOBEC1-enhanced IL8 production. | The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA.
Shimizu Y, Nishitsuji H, Marusawa H, Ujino S, Takaku H, Shimotohno K., Free PMC Article | 02/7/2015 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4). | APOBEC deaminases-mutases with defensive roles for immunity.
Prochnow C, Bransteitter R, Chen XS. | 05/10/2010 |
| The hypermutation activity of APOBEC-1 was decreased to background levels by a single point APOBEC-1 mutation of P29F or E181Q, while 50% of wild-type control editing at the normal site was retained. | Hypermutation induced by APOBEC-1 overexpression can be eliminated.
Chen Z, Eggerman TL, Bocharov AV, Baranova IN, Vishnyakova TG, Csako G, Patterson AP., Free PMC Article | 05/10/2010 |
| The data presented in this report suggested that similar regulatory mechanisms controlling the functional interaction of APOBEC-1 with ACF might be operational during enterocyte differentiation. | The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells.
Galloway CA, Smith HC., Free PMC Article | 03/22/2010 |
| Identified two novel variants, rs1349411 (APOBEC1) and rs1424032, for serum apoB levels in Mexicans. | Identification of two common variants contributing to serum apolipoprotein B levels in Mexicans.
Weissglas-Volkov D, Plaisier CL, Huertas-Vazquez A, Cruz-Bautista I, Riaño-Barros D, Herrera-Hernandez M, Riba L, Cantor RM, Sinsheimer JS, Aguilar-Salinas CA, Tusie-Luna T, Pajukanta P., Free PMC Article | 02/22/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesLarge-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease.
Schafmayer C, Völzke H, Buch S, Egberts J, Spille A, von Eberstein H, Franke A, Seeger M, Hinz S, Elsharawy A, Rosskopf D, Brosch M, Krawczak M, Foelsch UR, Schafmayer A, Lammert F, Schreiber S, Faendrich F, Hampe J, Tepel J, Schafmayer C, Völzke H, Buch S, Egberts J, Spille A, von Eberstein H, Franke A, Seeger M, Hinz S, Elsharawy A, Rosskopf D, Brosch M, Krawczak M, Foelsch UR, Schafmayer A, Lammert F, Schreiber S, Faendrich F, Hampe J, Tepel J. | 03/13/2008 |
| No evidence of association of APOBEC1 and PPARG with gallstone susceptibility was detected. | Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease.
Schafmayer C, Völzke H, Buch S, Egberts J, Spille A, von Eberstein H, Franke A, Seeger M, Hinz S, Elsharawy A, Rosskopf D, Brosch M, Krawczak M, Foelsch UR, Schafmayer A, Lammert F, Schreiber S, Faendrich F, Hampe J, Tepel J, Schafmayer C, Völzke H, Buch S, Egberts J, Spille A, von Eberstein H, Franke A, Seeger M, Hinz S, Elsharawy A, Rosskopf D, Brosch M, Krawczak M, Foelsch UR, Schafmayer A, Lammert F, Schreiber S, Faendrich F, Hampe J, Tepel J. | 01/21/2010 |
| apobec-1-mediated apoB mRNA editing is regulated by BAG-4 | Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing.
Lau PP, Chan L. | 01/21/2010 |
| APOBEC3G is not a nucleo-cytoplasmic shuttling protein like APOBEC-1 and activation-induced cytidine deaminase | APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic.
Bennett RP, Diner E, Sowden MP, Lees JA, Wedekind JE, Smith HC., Free PMC Article | 01/21/2010 |
| determination of multifunctional cycle and suppression of nonsense-mediated decay | The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay.
Chester A, Somasekaram A, Tzimina M, Jarmuz A, Gisbourne J, O'Keefe R, Scott J, Navaratnam N., Free PMC Article | 01/21/2010 |
| C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme | C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme.
Mukhopadhyay D, Anant S, Lee RM, Kennedy S, Viskochil D, Davidson NO., Free PMC Article | 01/21/2010 |
| expression of two proteins essential for apolipoprotein B mRNA editing from a single gene through alternative splicing | Two proteins essential for apolipoprotein B mRNA editing are expressed from a single gene through alternative splicing.
Dance GS, Sowden MP, Cartegni L, Cooper E, Krainer AR, Smith HC. | 01/21/2010 |
| apobec-1 complementation factor has a role in regulating nucleocytoplasmic import and shuttling | A novel nuclear localization signal in the auxiliary domain of apobec-1 complementation factor regulates nucleocytoplasmic import and shuttling.
Blanc V, Kennedy S, Davidson NO. | 01/21/2010 |
| Expression of Apobec1 in HepG2 cells resulted in apoB mRNA editing, leading to decreased apoB100 abundance (to 6% of control) and the appearance of apoB48. | Simultaneous expression of apolipoprotein B mRNA editing enzyme and scavenger receptor BI mediated by a therapeutic gene expression system.
Zhong S, Liu C, Haviland D, Doris PA, Teng BB. | 01/21/2010 |