| NLRP10 maintains epidermal homeostasis by promoting keratinocyte survival and P63-dependent differentiation and barrier function. | NLRP10 maintains epidermal homeostasis by promoting keratinocyte survival and P63-dependent differentiation and barrier function.
Cho Y, Cao Z, Luo X, Tian JJ, Hukkanen RR, Hussien R, Cancilla B, Chowdhury P, Li F, Ma S, LaGory EL, Schroeder M, Dusenberry A, Marshall L, Hawkins J, van Lookeren Campagne M, Zhou Y., Free PMC Article | 10/22/2024 |
| NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-kappaB signaling in human periodontal ligament cells. | NLRP10 promotes AGEs-induced NLRP1 and NLRP3 inflammasome activation via ROS/MAPK/NF-κB signaling in human periodontal ligament cells.
Yi X, Song Y, Xu J, Wang L, Liu L, Huang D, Zhang L. | 01/16/2024 |
| Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population. | Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population.
Kutsuwada Y, Yokota K, Yoshida K, Tsuda H, Watanabe K, Matsumoto A, Iwamoto S. | 03/19/2022 |
| this study shows that NLRP10 affects the stability of Abin-1 to control inflammatory responses | NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses.
Mirza N, Sowa AS, Lautz K, Kufer TA. | 11/9/2019 |
| Authors observed an important role of NLRP10 in cytokine and chemokine production as well as expression of NF-kappaB and MAPKs in CSE-exposed A549 cells. Furthermore, replenishment of A549 cell culture with recombinant IL-17A (rIL-17A) during NLRP10 knockdown rescued CSE-induced inflammatory responses. | Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms.
Kaur G, Bagam P, Pinkston R, Singh DP, Batra S. | 12/29/2018 |
| these data suggest that NLRP10 is involved in activating the ERK signalling pathway in oral epithelial cell line infected with Tannerella forsythia and Fusobacterium nucleatum | Involvement of NLRP10 in IL-1α induction of oral epithelial cells by periodontal pathogens.
Lee SJ, Choi BK. | 05/26/2018 |
| Review summarize recent advances of the role of of human and murine NLRP10 in innate and adaptive immune responses. [Review] | Roles of NLRP10 in innate and adaptive immunity.
Damm A, Lautz K, Kufer TA. | 12/28/2013 |
| These data revealed a novel role of NLRP10 in innate immune responses towards bacterial infection and suggest that NLRP10 functions as a scaffold for the formation of the NOD1-Nodosome. | NLRP10 enhances Shigella-induced pro-inflammatory responses.
Lautz K, Damm A, Menning M, Wenger J, Adam AC, Zigrino P, Kremmer E, Kufer TA. | 02/2/2013 |
| The results show that either deletion of the p53 binding elements within the PYNOD promoter or treatment with p53 inhibitor could significantly reduce PYNOD promoter activity. | Functional characterization of the p53 binding site in the human PYNOD promoter.
Zeng Q, Lu D, Tang Q, Tian L, Wang H, Tang S, Hu C. | 07/28/2012 |
| Transgenic PYNOD colocalizes with apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) and inhibits caspase-1-mediated interleukin (IL)-1beta processing without inhibiting caspase-4-mediated caspase-1 processing. | Anti-inflammatory activity of PYNOD and its mechanism in humans and mice.
Imamura R, Wang Y, Kinoshita T, Suzuki M, Noda T, Sagara J, Taniguchi S, Okamoto H, Suda T. | 07/26/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | The genetics of NOD-like receptors in Crohn's disease.
Cummings JR, Cooney RM, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon LR, Jewell DP. | 06/30/2010 |
| The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution. | A 2.7-kb deletion in the human NLRP10 gene exon 2 occurred after the human-chimpanzee divergence.
Ha HJ, Kim DS, Hahn Y. | 01/21/2010 |
| PYPAF3 is a feedback regulator of interleukin-1beta secretion, and PYPAF2 and PYPAF3, together with PYNOD, constitute an anti-inflammatory subgroup of PYRIN-containing apoptotic protease-activating factor-1-like proteins | PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion.
Kinoshita T, Wang Y, Hasegawa M, Imamura R, Suda T. | 01/21/2010 |
| PYNOD is a novel regulator of apoptosis and inflammation. | PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1.
Wang Y, Hasegawa M, Imamura R, Kinoshita T, Kondo C, Konaka K, Suda T. | 01/21/2010 |