| MiR-340-3p-HUS1 axis suppresses proliferation and migration in lung adenocarcinoma cells. | MiR-340-3p-HUS1 axis suppresses proliferation and migration in lung adenocarcinoma cells.
Ren K, Yu Y, Wang X, Liu H, Zhao J. | 04/17/2021 |
| In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor. | In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor.
Hong H, Yao S, Zhang Y, Ye Y, Li C, Hu L, Sun Y, Huang HY, Ji H., Free PMC Article | 01/9/2021 |
| Low HUS1 expression is associated with hepatocellular carcinoma. | HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma.
Zhou ZQ, Zhao JJ, Chen CL, Liu Y, Zeng JX, Wu ZR, Tang Y, Zhu Q, Weng DS, Xia JC. | 07/6/2019 |
| These results suggest that p21(Waf1/CIP1) and Hus1 play crucial roles in the generation and transmission of bystander damage signals after low-dose alpha-particle irradiation. | The Roles of p21(Waf1/CIP1) and Hus1 in Generation and Transmission of Damage Signals Stimulated by Low-Dose Alpha-Particle Irradiation.
Zhao Y, Ma X, Wang J, Chen S, Yuan H, Xu A, Hang H, Wu L. | 04/23/2016 |
| adenine glycosylase activity, mismatch recognition properties and interaction with protein partners of MUTYH and 5 MAP variants were examined; P502L and R520Q had reduced affinity for PCNA; only Q324H was found to have reduced affinity for Hus1 | Distinct functional consequences of MUTYH variants associated with colorectal cancer: Damaged DNA affinity, glycosylase activity and interaction with PCNA and Hus1.
Brinkmeyer MK, David SS., Free PMC Article | 02/20/2016 |
| Intramolecular binding of the rad9 C-terminus in the checkpoint clamp Rad9-Hus1-Rad1 is closely linked with its DNA binding. | Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding.
Takeishi Y, Iwaya-Omi R, Ohashi E, Tsurimoto T., Free PMC Article | 11/7/2015 |
| these pockets were not required for 9-1-1 chromatin localization or ATR-mediated CHK1 activation but were necessary for interactions between HUS1 and its binding partner MYH | Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions.
Lim PX, Patel DR, Poisson KE, Basuita M, Tsai C, Lyndaker AM, Hwang BJ, Lu AL, Weiss RS., Free PMC Article | 09/12/2015 |
| Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue. | Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue.
Štorcelová M, Vicián M, Reis R, Zeman M, Herichová I. | 06/14/2014 |
| HUS1 polymorphisms act as risk breast cancer modifiers in the group of non-carriers of BRCA1/2 mutations. | Low penetrance alleles as risk modifiers in familial and sporadic breast cancer.
Esteban Cardeñosa E, de Juan Jiménez I, Palanca Suela S, Chirivella González I, Segura Huerta A, Santaballa Beltran A, Casals El Busto M, Barragán González E, Fuster Lluch O, Bermúdez Edo J, Bolufer Gilabert P. | 04/27/2013 |
| Data show models for the ternary PCNA/FEN1/DNA and Rad9-Rad1-Hus1 (9-1-1 complex)/FEN1/DNA assemblies. | Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
Querol-Audí J, Yan C, Xu X, Tsutakawa SE, Tsai MS, Tainer JA, Cooper PK, Nogales E, Ivanov I., Free PMC Article | 08/25/2012 |
| The HUS1 is loaded to damaged sites where it serves as a platform for the selective recruitment of checkpoint and repair proteins. | 9-1-1: PCNA's specialized cousin.
Eichinger CS, Jentsch S. | 04/7/2012 |
| The HUS1 protein interacts with casein kinase 2. | Casein kinase 2-dependent phosphorylation of human Rad9 mediates the interaction between human Rad9-Hus1-Rad1 complex and TopBP1.
Takeishi Y, Ohashi E, Ogawa K, Masai H, Obuse C, Tsurimoto T. | 11/27/2010 |
| 9-1-1 complex is a component of the mismatch repair involved in MNNG-induced damage response. | Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1.
Bai H, Madabushi A, Guan X, Lu AL., Free PMC Article | 08/2/2010 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q., Free PMC Article | 04/7/2010 |
| Rad9-Rad1-Hus1 complex enhances in vitro activity of 8-oxoguanine DNA glycosylase. | Repair activities of human 8-oxoguanine DNA glycosylase are stimulated by the interaction with human checkpoint sensor Rad9-Rad1-Hus1 complex.
Park MJ, Park JH, Hahm SH, Ko SI, Lee YR, Chung JH, Sohn SY, Cho Y, Kang LW, Han YS. | 01/25/2010 |
| The DNA binding domain (DBD) within the hLigI catalytic fragment interacts with both PCNA and the heterotrimeric cell-cycle checkpoint clamp, hRad9-hRad1-hHus1 (9-1-1). | The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1.
Song W, Pascal JM, Ellenberger T, Tomkinson AE., Free PMC Article | 01/21/2010 |
| The interdomain connecting loops (IDC loop) of hRad9, hHus1, and hRad1 are largely divergent and unique structural features of the 9-1-1 complex that are proposed to contribute to DNA damage recognition. | Structure and functional implications of the human rad9-hus1-rad1 cell cycle checkpoint complex.
Xu M, Bai L, Gong Y, Xie W, Hang H, Jiang T., Free PMC Article | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La Bella V, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ., Free PMC Article | 03/25/2009 |
| Loss of HUS1 sensitizes cells to etopside-induced apoptosis by regulating BH3-only proteins. | Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins.
Meyerkord CL, Takahashi Y, Araya R, Takada N, Weiss RS, Wang HG., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (5) articlesA Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. Genetic susceptibility to distinct bladder cancer subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, EPICURO/Spanish Bladder Cancer Study investigators. PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD 3rd, Menashe I, He X, Chanock S, Lan Q. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD 3rd, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q. | 09/24/2008 |
| Hus1 levels correlated significantly with the clinicopathologic factors of bad prognosis in epithelial ovarian tumors | Expression of DNA damage checkpoint protein Hus1 in epithelial ovarian tumors correlates with prognostic markers.
de la Torre J, Gil-Moreno A, García A, Rojo F, Xercavins J, Salido E, Freire R. | 01/21/2010 |
| Human thymine DNA glycosylase activity is significantly stimulated by hHus1, hRad1, hRad9 separately, and by the 9-1-1 complex. | The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.
Guan X, Madabushi A, Chang DY, Fitzgerald ME, Shi G, Drohat AC, Lu AL., Free PMC Article | 01/21/2010 |
| Jab1 physically associates with the 9-1-1 complex (Rad1-Rad9-Hus1) | Jab1 mediates protein degradation of the Rad9-Rad1-Hus1 checkpoint complex.
Huang J, Yuan H, Lu C, Liu X, Cao X, Wan M., Free PMC Article | 01/21/2010 |
| we report successful tri-cistronic cloning, overexpression and purification of a three-protein complex of Rad9, Rad1 and Hus1 using a single hexa-histidine tag. | Tri-cistronic cloning, overexpression and purification of human Rad9, Rad1, Hus1 protein complex.
Singh VK, Nurmohamed S, Davey SK, Jia Z. | 01/21/2010 |
| The long-patch base excision machinery is an important target of the Rad9-Rad1-Hus1 complex, thus enhancing the quality control of DNA. | The human checkpoint sensor and alternative DNA clamp Rad9-Rad1-Hus1 modulates the activity of DNA ligase I, a component of the long-patch base excision repair machinery.
Smirnova E, Toueille M, Markkanen E, Hübscher U., Free PMC Article | 01/21/2010 |