| Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. | Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development.
Nikolić J, Vukojević K, Šoljić V, Mišković J, Orlović Vlaho M, Saraga-Babić M, Filipović N., Free PMC Article | 02/17/2023 |
| Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study. | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study.
Berens S, Dong Y, Fritz N, Walstab J, D'Amato M, Zheng T, Wahl V, Boekstegers F, Bermejo JL, Martinez C, Schmitteckert S, Clevers E, Engel F, Gauss A, Herzog W, Spiller R, Goebel-Stengel M, Mönnikes H, Andresen V, Thomas F, Keller J, Pehl C, Stein-Thöringer C, Clarke G, Dinan TG, Quigley EM, Sayuk G, Simrén M, Tesarz J, Rappold G, van Oudenhove L, Schaefert R, Niesler B., Free PMC Article | 07/23/2022 |
| Fear reacquisition and symptoms of combat-related PTSD: Specificity and preliminary examination of the influence of the 5-HT3A receptor gene. | Fear reacquisition and symptoms of combat-related PTSD: Specificity and preliminary examination of the influence of the 5-HT3A receptor gene.
Olatunji BO, Cox RC, Blackford JU. | 05/21/2022 |
| 5'UTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls-Preliminary evidence. | 5'UTR polymorphism in the serotonergic receptor HTR3A gene is differently associated with striatal Dopamine D2/D3 receptor availability in the right putamen in Fibromyalgia patients and healthy controls-Preliminary evidence.
Ledermann K, Hasler G, Jenewein J, Sprott H, Schnyder U, Martin-Soelch C. | 08/14/2021 |
| 5-HT3 Signaling Alters Development of Sacral Neural Crest Derivatives That Innervate the Lower Urinary Tract. | 5-HT3 Signaling Alters Development of Sacral Neural Crest Derivatives That Innervate the Lower Urinary Tract.
Ritter KE, Buehler DP, Asher SB, Deal KK, Zhao S, Guo Y, Southard-Smith EM., Free PMC Article | 07/31/2021 |
| Orthosteric and Allosteric Activation of Human 5-HT3A Receptors. | Orthosteric and Allosteric Activation of Human 5-HT(3)A Receptors.
Rodriguez Araujo N, Fabiani C, Mazzarini Dimarco A, Bouzat C, Corradi J., Free PMC Article | 05/15/2021 |
| High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition. | High-resolution structures of multiple 5-HT(3A)R-setron complexes reveal a novel mechanism of competitive inhibition.
Basak S, Kumar A, Ramsey S, Gibbs E, Kapoor A, Filizola M, Chakrapani S., Free PMC Article | 05/15/2021 |
| HTR3A is correlated with unfavorable histology and promotes proliferation through ERK phosphorylation in lung adenocarcinoma. | HTR3A is correlated with unfavorable histology and promotes proliferation through ERK phosphorylation in lung adenocarcinoma.
Tone M, Tahara S, Nojima S, Motooka D, Okuzaki D, Morii E., Free PMC Article | 12/19/2020 |
| Voltage-gated fluorometry was used to characterize conformational changes in the extracellular domain of the 5-HT3A receptor. | Conformational Changes in the 5-HT(3A) Receptor Extracellular Domain Measured by Voltage-Clamp Fluorometry.
Munro L, Ladefoged LK, Padmanathan V, Andersen S, Schiøtt B, Kristensen AS. | 03/7/2020 |
| This study demonstrated that the C and E subunits when assembled as simple or complex heteromeric 5-HT3 receptors may alter efficacies of serotonin and clinically used antagonists. | The C and E subunits of the serotonin 5-HT(3) receptor subtly modulate electrical properties of the receptor.
Yaakob NS, Nguyen DT, Exintaris B, Irving HR. | 10/6/2018 |
| Methylation status of the HTR3A gene in mothers is linked to maternal violence-related psychopathology, trauma-induced brain activation patterns, and child attachment disturbance during a sensitive period in the development of self-regulation. | The association of serotonin receptor 3A methylation with maternal violence exposure, neural activity, and child aggression.
Schechter DS, Moser DA, Pointet VC, Aue T, Stenz L, Paoloni-Giacobino A, Adouan W, Manini A, Suardi F, Vital M, Sancho Rossignol A, Cordero MI, Rothenberg M, Ansermet F, Rusconi Serpa S, Dayer AG. | 03/10/2018 |
| This study did not found HTR3A play a major role in predicting Antipsychotic-Induced Weight Gain. | Association Study of Serotonin 3 Receptor Subunit Gene Variants in Antipsychotic-Induced Weight Gain.
Zai CC, Tiwari AK, Chowdhury NI, Brandl EJ, Shaikh SA, Freeman N, Lieberman JA, Meltzer HY, Kennedy JL, Müller DJ., Free PMC Article | 02/10/2018 |
| Methylation pattern changes in the 5-HTR3A gene were associated with suicidal behavior in borderline personality disorder, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD). | Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk.
Sudol K, Mann JJ. | 12/30/2017 |
| findings suggest that HTR3A mRNA expression levels were positively correlated with craving in Han Chinese alcohol-dependent patients. | The association of HTR3A mRNA expression and craving in Han Chinese alcohol-dependent patients: a preliminary study.
Xu YH, Wang LL, Shi L, Lei JP, Miao Q, Liu TQ, Hao W, Lu L, Zhang RL. | 11/11/2017 |
| Study provides structural data showing the orientation of palonosetron in a 5-HT3 receptor binding site mimic, combined with functional data in the 5-HT3 receptor, provide an explanation for the high affinity and long-lived actions of this compound. These are likely due to specific interactions formed with binding site residues, and its location as a tight and effective wedge in the binding pocket. | Palonosetron-5-HT(3) Receptor Interactions As Shown by a Binding Protein Cocrystal Structure.
Price KL, Lillestol RK, Ulens C, Lummis SC. | 10/21/2017 |
| Studies have demonstrated that 5-HT3 receptors modulate the activity of vascular and non-vascular smooth muscles. | Stimulation of contractions in pregnant human myometrium is associated with 5-HT3 receptors.
Li H, Diao M, Ni J, Li P, Zhu Q, Wan YL, Ma YS, Lin XM. | 08/19/2017 |
| The HTR3A rs1062613 polymorphisms do not seem to directly influence experimental muscle pain in healthy individuals. However, women reported higher pain intensity and larger pain area than men, which might partly be attributed to genotype. | Influence of Polymorphisms in the HTR3A and HTR3B Genes on Experimental Pain and the Effect of the 5-HT3 Antagonist Granisetron.
Louca Jounger S, Christidis N, Hedenberg-Magnusson B, List T, Svensson P, Schalling M, Ernberg M., Free PMC Article | 07/8/2017 |
| Studies with 16 arylguanidines found that their functional activity spanned a broad spectrum from superagonist to full agonist, partial agonist, and antagonist at 5-HT3 receptors; results confirm the utility of phenylguanidine as an extremely versatile scaffold in the design of 5-HT3 ligands with a "tunable" level of agonist or antagonist activity | Superagonist, Full Agonist, Partial Agonist, and Antagonist Actions of Arylguanidines at 5-Hydroxytryptamine-3 (5-HT(3)) Subunit A Receptors.
Alix K, Khatri S, Mosier PD, Casterlow S, Yan D, Nyce HL, White MM, Schulte MK, Dukat M. | 06/24/2017 |
| Analysis of our small Chinese sample revealed a significant association of HTR3A with bipolar disorder, but yielded no evidence of an association between HTR3B and bipolar disorder. Furthermore, evidence for an association was found for a haplotype of HTR3A. | Associations of serotonin receptor gene HTR3A, HTR3B, and HTR3A haplotypes with bipolar disorder in Chinese patients.
Jian J, Li C, Xu J, Qiao D, Mi G, Chen X, Tang M. | 02/25/2017 |
| Alternative Viewpoint Against Breast Cancer Based on Selective Serotonin Receptors 5HTR3A and 5HTR2A Antagonists that can Mediate Apoptosis in MCF-7 Cell Line | Alternative Viewpoint Against Breast Cancer Based on Selective Serotonin Receptors 5HTR3A and 5HTR2A Antagonists that can Mediate Apoptosis in MCF-7 Cell Line.
Hejazi SH, Ahangari G, Deezagi A. | 10/22/2016 |
| Serotonin 3A receptor (5-HT3AR) is associated at the genetic and epigenetic levels with a variety of psychiatric disorders. | METHYLATION OF SEROTONIN RECEPTOR 3A IN ADHD, BORDERLINE PERSONALITY, AND BIPOLAR DISORDERS: LINK WITH SEVERITY OF THE DISORDERS AND CHILDHOOD MALTREATMENT.
Perroud N, Zewdie S, Stenz L, Adouan W, Bavamian S, Prada P, Nicastro R, Hasler R, Nallet A, Piguet C, Paoloni-Giacobino A, Aubry JM, Dayer A. | 09/3/2016 |
| A gene-environment interaction is revealed between childhood trauma and 5-htr3a polymorphisms. | Influence of the 5-HT3A Receptor Gene Polymorphism and Childhood Sexual Trauma on Central Serotonin Activity.
Jang KI, Lee SH, Huh HJ, Chae JH., Free PMC Article | 07/16/2016 |
| 5-HT3A receptor distal targeting in axons and dendrites depends on P2X2R expression. | A New Mechanism of Receptor Targeting by Interaction between Two Classes of Ligand-Gated Ion Channels.
Emerit MB, Baranowski C, Diaz J, Martinez A, Areias J, Alterio J, Masson J, Boué-Grabot E, Darmon M., Free PMC Article | 06/28/2016 |
| Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors | Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors.
Morton RA, Baptista-Hon DT, Hales TG, Lovinger DM., Free PMC Article | 05/14/2016 |
| Data indicate that no two n-alkanols act alike, their spectra of effects on serotonin receptor 3A (5-HT3A) receptors differ. | Fast and slow interactions of n-alkanols with human 5-HT3A receptors: Implications for anesthetic mechanisms.
Decker AM, Witten S, Barann M, Urban BW. | 10/3/2015 |