| Peroxisomal ERK mediates Akh/glucagon action and glycemic control. | Peroxisomal ERK mediates Akh/glucagon action and glycemic control.
Li J, Dang P, Li Z, Zhao T, Cheng D, Pan D, Yuan Y, Song W. | 12/4/2023 |
| the common docking site is in an energetically strained configuration, and this helps drive conformational changes at distal sites on ERK2 during docking interactions. | Functional divergence caused by mutations in an energetic hotspot in ERK2.
Taylor CA 4th, Cormier KW, Keenan SE, Earnest S, Stippec S, Wichaidit C, Juang YC, Wang J, Shvartsman SY, Goldsmith EJ, Cobb MH., Free PMC Article | 04/4/2020 |
| Results suggest that Rolled/ERK-MAPK activation in somatic cyst cells downstream of EGFR is essential for synchronizing the germ-cell divisions within a cyst at every step during the transit amplification. | Somatic ERK activation during transit amplification is essential for maintaining the synchrony of germline divisions in Drosophila testis.
Gupta S, Varshney B, Chatterjee S, Ray K., Free PMC Article | 03/23/2019 |
| In the presence of USP47, MAPK would be stabilized as USP47 acts to deubiquitinate MAPK, thus counteracting the direct ubiquitination of MAPK by POE/UBR4 activity. | The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila.
Ashton-Beaucage D, Lemieux C, Udell CM, Sahmi M, Rochette S, Therrien M., Free PMC Article | 06/24/2017 |
| PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells, leading to the expression of Dilp8. | The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model.
Demay Y, Perochon J, Szuplewski S, Mignotte B, Gaumer S., Free PMC Article | 07/25/2015 |
| Holn1 acts downstream of EGFR and ERK signaling in the Grh/Fos mediated wound closure pathway. | Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila.
Geiger JA, Carvalho L, Campos I, Santos AC, Jacinto A., Free PMC Article | 04/14/2012 |
| Corto, rl and dMP1 interact during wing tissue differentiation; Corto, ERK(rl) and dMP1 form a complex in the nucleus and co-localize on several sites on polytene chromosomes | The MAP kinase ERK and its scaffold protein MP1 interact with the chromatin regulator Corto during Drosophila wing tissue development.
Mouchel-Vielh E, Rougeot J, Decoville M, Peronnet F., Free PMC Article | 06/25/2011 |
| These results identify a role for the Exon Junction Complex (EJC) in the splicing of a subset of transcripts and suggest that RAS/MAPK signaling depends on the regulation of MAPK levels by the EJC. | The exon junction complex controls the splicing of MAPK and other long intron-containing transcripts in Drosophila.
Ashton-Beaucage D, Udell CM, Lavoie H, Baril C, Lefrançois M, Chagnon P, Gendron P, Caron-Lizotte O, Bonneil E, Thibault P, Therrien M. | 11/13/2010 |
| MAPK is the primary functional target of mago in eye development; in cultured cells, Mago knockdown disproportionately affects other large genes located in heterochromatin | Exon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic gene.
Roignant JY, Treisman JE., Free PMC Article | 11/13/2010 |
| Data show that Fak56 suppresses MAPK activation in neuromuscular junction growth. | Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth.
Tsai PI, Kao HH, Grabbe C, Lee YT, Ghose A, Lai TT, Peng KP, Van Vactor D, Palmer RH, Chen RH, Yeh SR, Chien CT., Free PMC Article | 01/21/2010 |
| These data suggest a model in which ERK map kinase phosphorylation must be spatially coupled to integrin-mediated DIM-7 activation to make a complex that can be imported efficiently. | Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7.
James BP, Bunch TA, Krishnamoorthy S, Perkins LA, Brower DL., Free PMC Article | 01/21/2010 |