| Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression. | Comprehensive intratumoral heterogeneity landscaping of liver hepatocellular carcinoma and discerning of APLP2 in cancer progression.
Tao Z, Huang J, Li J. | 01/15/2024 |
| Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis. | Implication of Amyloid Precursor-like Protein 2 Expression in Cutaneous Squamous Cell Carcinoma Pathogenesis.
Huang X, Yang J, Xi H, Zhang M, Oh Y, Jin Z, Zheng Z., Free PMC Article | 01/4/2024 |
| Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage. | Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
Chen J, Tang F, Li H, Wu X, Yang Y, Liu Z, Huang X, Wang J, Zheng R, Wang L, Liu H, Xu J, Wang P, Liu F. | 11/3/2023 |
| APLP2 is predominantly cleaved by beta-secretase and gamma-secretase in the human brain. | APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain.
Yanagida K, Maruyama R, Tagami S, Kudo T, Okochi M, Fukumori A. | 03/8/2023 |
| APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China. | APLP2 gene polymorphisms are associated with high TC and LDL-C levels in Chinese population in Xinjiang, China.
Abuzhalihan J, Adi D, Wang YT, Li Y, Yang YN, Ma X, Li XM, Xie X, Liu F, Chen BD, Gai MT, Fu ZY, Ma YT., Free PMC Article | 04/3/2021 |
| our findings indicate that beta2m regulates pancreatic cancer cell migration, and furthermore suggest that APLP2 is an intermediary in this process. | Beta 2-microglobulin regulates amyloid precursor-like protein 2 expression and the migration of pancreatic cancer cells.
Sliker BH, Goetz BT, Peters HL, Poelaert BJ, Borgstahl GEO, Solheim JC., Free PMC Article | 08/1/2020 |
| the expression of APLP2 might correlate with tumor development and be a prognostic factor for patients with glioblastoma | Expression of amyloid precursor-like protein 2 (APLP2) in glioblastoma is associated with patient prognosis.
Chen Y, Wang H, Tan C, Yan Y, Shen J, Huang Q, Xu T, Lin J, Chen J. | 09/15/2018 |
| These findings suggest that the identified APLP2, RRM2, and PRC1 signature could be useful for distinguishing between benign (follicular adenoma) and malignant (follicular carcionma and follicular variant of papillary carcinoma) tumors of the thyroid follicular epithelium. | APLP2, RRM2, and PRC1: New Putative Markers for the Differential Diagnosis of Thyroid Follicular Lesions.
Castelblanco E, Zafon C, Maravall J, Gallel P, Martinez M, Capel I, Bella MR, Halperin I, Temprana J, Iglesias C, Puig-Domingo M, Robledo M, Matias-Guiu X, Mauricio D. | 02/24/2018 |
| This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development. | APLP2 Regulates Refractive Error and Myopia Development in Mice and Humans.
Tkatchenko AV, Tkatchenko TV, Guggenheim JA, Verhoeven VJ, Hysi PG, Wojciechowski R, Singh PK, Kumar A, Thinakaran G, Consortium for Refractive Error and Myopia (CREAM), Williams C., Free PMC Article | 04/30/2016 |
| Data show that amyloid precursor-like protein 2 (APLP2) expression is elevated in pancreatic cancer metastases. | Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis.
Pandey P, Rachagani S, Das S, Seshacharyulu P, Sheinin Y, Naslavsky N, Pan Z, Smith BL, Peters HL, Radhakrishnan P, McKenna NR, Giridharan SS, Haridas D, Kaur S, Hollingsworth MA, MacDonald RG, Meza JL, Caplan S, Batra SK, Solheim JC., Free PMC Article | 12/5/2015 |
| We conclude that PCSK9 enhances the degradation of the LDLR independently of either APLP2 or sortilin both ex vivo and in mice. | Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.
Butkinaree C, Canuel M, Essalmani R, Poirier S, Benjannet S, Asselin MC, Roubtsova A, Hamelin J, Marcinkiewicz J, Chamberland A, Guillemot J, Mayer G, Sisodia SS, Jacob Y, Prat A, Seidah NG., Free PMC Article | 10/24/2015 |
| APLP1 and APLP2, behave similarly to APP in that they both associate with assembled NMDA receptors in the endoplasmic reticulum | APLP1 and APLP2, members of the APP family of proteins, behave similarly to APP in that they associate with NMDA receptors and enhance NMDA receptor surface expression.
Cousins SL, Dai W, Stephenson FA. | 09/5/2015 |
| our discoveries establish a role for APLP2 in the growth of pancreatic cancer cells and show that inhibitors preventing APLP2 cleavage reduce the viability of pancreatic cancer cells. | Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells.
Peters HL, Tuli A, Wang X, Liu C, Pan Z, Ouellette MM, Hollingsworth MA, Macdonald RG, Solheim JC., Free PMC Article | 01/4/2014 |
| amyloid precursor protein-like protein-2, but not amyloid precursor protein, is involved in mediating postendocytic delivery of PCSK9 to lysosomes and is therefore important for PCSK9 function | Characterization of proprotein convertase subtilisin/kexin type 9 (PCSK9) trafficking reveals a novel lysosomal targeting mechanism via amyloid precursor-like protein 2 (APLP2).
DeVay RM, Shelton DL, Liang H., Free PMC Article | 06/8/2013 |
| Aberrant enhancement of YWK-II/APLP2 by nuclear export of Bat3 may play a role in cancer development by inhibiting cell apoptosis. | Regulation of apoptosis by Bat3-enhanced YWK-II/APLP2 protein stability.
Wu W, Song W, Li S, Ouyang S, Fok KL, Diao R, Miao S, Chan HC, Wang L. | 04/27/2013 |
| APP and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis. | Structural aspects and physiological consequences of APP/APLP trans-dimerization.
Baumkötter F, Wagner K, Eggert S, Wild K, Kins S., Free PMC Article | 12/22/2012 |
| APLP-2 (and APLP1) are capable of activating gene transcription via binding to Mint3. | Signaling via amyloid precursor-like proteins APLP1 and APLP2.
Orcholski ME, Zhang Q, Bredesen DE. | 03/10/2012 |
| Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2. | Regulation of major histocompatibility complex class I molecule expression on cancer cells by amyloid precursor-like protein 2.
Peters HL, Tuli A, Sharma M, Naslavsky N, Caplan S, MacDonald RG, Solheim JC., Free PMC Article | 01/21/2012 |
| proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase | Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.
Hogl S, Kuhn PH, Colombo A, Lichtenthaler SF., Free PMC Article | 10/22/2011 |
| The interaction between APLP2 and ataxin-7 and proteolytic processing of APLP2 may contribute to the pathogenesis of spinocerebellar ataxia type 7. | Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear inclusions and cytotoxicity in spinocerebellar ataxia-7 (SCA7).
Takahashi-Fujigasaki J, Breidert T, Fujigasaki H, Duyckaerts C, Camonis JH, Brice A, Lebre AS. | 10/1/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| APLP2 has a multistep trafficking function that influences the expression of major histocompatibility complex class I molecules at the plasma membrane | Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation.
Tuli A, Sharma M, Capek HL, Naslavsky N, Caplan S, Solheim JC., Free PMC Article | 01/21/2010 |
| Coexpression of APP with APLP1 or APLP2 leads to diminished generation of Abeta42 | Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.
Kaden D, Voigt P, Munter LM, Bobowski KD, Schaefer M, Multhaup G. | 01/21/2010 |
| APLP2/MHC association is influenced by multiple domains of the MHC class I heavy chain and by beta(2)m's effects on the conformation of the heavy chain. | Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules.
Tuli A, Sharma M, Naslavsky N, Caplan S, Solheim JC., Free PMC Article | 01/21/2010 |
| APLP2 modulates the stability and endocytosis of K(d) molecules | Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule.
Tuli A, Sharma M, McIlhaney MM, Talmadge JE, Naslavsky N, Caplan S, Solheim JC., Free PMC Article | 01/21/2010 |