Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60. | Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60. Wang JC, Chen L., Free PMC Article | 11/13/2021 |
Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients. | Overexpression of HSP10 correlates with HSP60 and Mcl-1 levels and predicts poor prognosis in non-small cell lung cancer patients. Tang Y, Yang Y, Luo J, Liu S, Zhan Y, Zang H, Zheng H, Zhang Y, Feng J, Fan S, Wen Q., Free PMC Article | 10/23/2021 |
An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space. | An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space. Bie AS, Cömert C, Körner R, Corydon TJ, Palmfeldt J, Hipp MS, Hartl FU, Bross P., Free PMC Article | 05/29/2021 |
structural basis for active single- and double-ring complexes coexisting in the mHsp60-mHsp10 chaperonin reaction cycle | Structural basis for active single and double ring complexes in human mitochondrial Hsp60-Hsp10 chaperonin. Gomez-Llorente Y, Jebara F, Patra M, Malik R, Nisemblat S, Chomsky-Hecht O, Parnas A, Azem A, Hirsch JA, Ubarretxena-Belandia I., Free PMC Article | 08/12/2020 |
elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma | Elevated expression of HSP10 protein inhibits apoptosis and associates with poor prognosis of astrocytoma. Fan W, Fan SS, Feng J, Xiao D, Fan S, Luo J., Free PMC Article | 10/28/2017 |
miR-146a, miR-146b, and miR-155 are exerting anti-inflammatory properties by down-regulating IL-6 and IL-8, and influencing the expression of HSP10 in the activated endothelium | miR-146a, miR-146b, and miR-155 increase expression of IL-6 and IL-8 and support HSP10 in an In vitro sepsis model. Pfeiffer D, Roßmanith E, Lang I, Falkenhagen D., Free PMC Article | 09/30/2017 |
High expression of HSP10 is negatively associated with estrogen receptor/progesterone receptor status and might be a novel independent biomarker for poor prognosis in invasive ductal breast carcinoma. | High expression of heat shock protein 10 correlates negatively with estrogen/progesterone receptor status and predicts poor prognosis in invasive ductal breast carcinoma. Chu S, Wen Q, Qing Z, Luo J, Wang W, Chen L, Feng J, Xu L, Zang H, Fan S. | 09/2/2017 |
EPF induces the differentiation of regulatory T cells and increases their immunosuppressive activities. | Early Pregnancy Factor Enhances the Generation and Function of CD4(+)CD25(+) Regulatory T Cells. Chen Q, Zhu X, Chen R, Liu J, Liu P, Hu A, Wu L, Hua H, Yuan H. | 04/8/2017 |
Hsp10 and Hsp60 may be implicated in carcinogenesis from its very early steps in colorectal cancer. | Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of large bowel cancer. Rappa F, Pitruzzella A, Marino Gammazza A, Barone R, Mocciaro E, Tomasello G, Carini F, Farina F, Zummo G, Conway de Macario E, Macario AJ, Cappello F., Free PMC Article | 03/11/2017 |
Data indicate that on addition of the heat-shock proteins GroEL-GroES molecular chaperone system, the folding of the nascent chemokine receptor type 5 (CCR5) was significantly enhanced. | Folding of newly translated membrane protein CCR5 is assisted by the chaperonin GroEL-GroES. Chi H, Wang X, Li J, Ren H, Huang F., Free PMC Article | 10/22/2016 |
Cpn10 has a role in the spatial regulation of NPAT signaling | Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Ling Zheng L, Wang FY, Cong XX, Shen Y, Rao XS, Huang DS, Fan W, Yi P, Wang XB, Zheng L, Zhou YT, Luo Y., Free PMC Article | 04/23/2016 |
Hsp10 has a role in nuclear localization and lung cells response to cigarette smoke | Hsp10 nuclear localization and changes in lung cells response to cigarette smoke suggest novel roles for this chaperonin. Corrao S, Anzalone R, Lo Iacono M, Corsello T, Di Stefano A, D'Anna SE, Balbi B, Carone M, Sala A, Corona D, Timperio AM, Zolla L, Farina F, de Macario EC, Macario AJ, Cappello F, La Rocca G., Free PMC Article | 07/25/2015 |
Hsp10 and Hsp90 may be involved in large bowel carcinogenesis. | Comparative analysis of Hsp10 and Hsp90 expression in healthy mucosa and adenocarcinoma of the large bowel. Rappa F, Sciume C, Lo Bello M, Bavisotto CC, Marino Gammazza A, Barone R, Campanella C, David S, Carini F, Zarcone F, Rizzuto S, Lena A, Tomasello G, Uzzo ML, Spatola GF, Bonaventura G, Leone A, Gerbino A, Cappello F, Bucchieri F, Zummo G, Farina F. | 11/22/2014 |
Data show that that in presence of 300 mg/mL Ficoll the thermodynamic stability of each cpn10 monomer increases by over 30%, whereas the interfaces are stabilized by less than 10%. | Macromolecular crowding extended to a heptameric system: the Co-chaperonin protein 10. Aguilar X, F Weise C, Sparrman T, Wolf-Watz M, Wittung-Stafshede P. | 08/6/2011 |
HSP10 protein was detected only in oocytes from human preantral follicles, whereas in antral follicles, it was localised in oocytes, granulosa cells, theca cells and stroma cells. | Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles. Fan L, Fan L, Ling J, Ma X, Cui YG, Liu JY. | 01/25/2010 |
HSP10 was identified as a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes. | HSP 10 is a new autoantigen in both autoimmune pancreatitis and fulminant type 1 diabetes. Takizawa S, Endo T, Wanjia X, Tanaka S, Takahashi M, Kobayashi T. | 01/21/2010 |
Results describe a novel function of chaperonin 10 as a general differentiation factor, not limited to erythroid cells, and show how this biological effect is mediated by GSK-3alpha/beta. | Chaperonin 10 as an endothelial-derived differentiation factor: role of glycogen synthase kinase-3. Dobocan MC, Sadvakassova G, Congote LF. | 01/21/2010 |
The effects of cpn 10 on cells of the oligodendrocyte lineage, were assessed. | Recombinant EPF/chaperonin 10 promotes the survival of O4-positive pro-oligodendrocytes prepared from neonatal rat brain. McCombe PA., Free PMC Article | 01/21/2010 |
the GroEL-GroES chamber behaves as a passive "Anfinsen cage" whose primary role is to prevent multimolecular association during folding. | Chaperonin chamber accelerates protein folding through passive action of preventing aggregation. Apetri AC, Horwich AL., Free PMC Article | 01/21/2010 |
In patients with serous ovarian carcinomas, gene expression analysis coupled with immunohistochemistry allowed the identification of HSP10 as an independent factor of progression-free survival. | Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas. Têtu B, Popa I, Bairati I, L'Esperance S, Bachvarova M, Plante M, Harel F, Bachvarov D. | 01/21/2010 |
Data show that Hhsp10 formed fibrils from only the acidic unfolded state and Core peptide regions of these protein fibrils were determined by proteolysis followed by a combination of Edman degradation and mass spectroscopy analyses. | Fibril formation of hsp10 homologue proteins and determination of fibril core regions: differences in fibril core regions dependent on subtle differences in amino acid sequence. Yagi H, Sato A, Yoshida A, Hattori Y, Hara M, Shimamura J, Sakane I, Hongo K, Mizobata T, Kawata Y. | 01/21/2010 |
Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesGenetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ. Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma. Ralph S, Brenchley PE, Summers A, Rosa DD, Swindell R, Jayson GC. | 03/13/2008 |
the cpn10 interfaces can adapt to structural alterations without loss of either subunit-subunit affinity or heptamer specificity | Interface mutation in heptameric co-chaperonin protein 10 destabilizes subunits but not interfaces. Brown C, Liao J, Wittung-Stafshede P. | 01/21/2010 |
Results describe the time-resolved folding and assembly mechanism of the heptameric co-chaperonin protein 10 (cpn10) in vitro. | Kinetic folding and assembly mechanisms differ for two homologous heptamers. Luke K, Perham M, Wittung-Stafshede P. | 01/21/2010 |
The genome structure of this gene has been established. | Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. Hansen JJ, Bross P, Westergaard M, Nielsen MN, Eiberg H, Børglum AD, Mogensen J, Kristiansen K, Bolund L, Gregersen N. | 01/21/2010 |