| HSP-27 and HSP-70 negatively regulate protective defence responses from macrophages during mycobacterial infection. | HSP-27 and HSP-70 negatively regulate protective defence responses from macrophages during mycobacterial infection.
Saraswati SSK, Rana AK, Singh A, Anang V, Singh A, Natarajan K. | 12/1/2023 |
| Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc. | Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc.
Bi X, Zhang M, Zhou J, Yan X, Cheng L, Luo L, Huang C, Yin Z. | 11/7/2023 |
| HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury. | HSPB2 facilitates neural regeneration through autophagy for sensorimotor recovery after traumatic brain injury.
Huang Y, Meng S, Wu B, Shi H, Wang Y, Xiang J, Li J, Shi Z, Wu G, Lyu Y, Jia X, Hu J, Xu ZX, Gao Y., Free PMC Article | 08/25/2023 |
| Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression. | Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression.
Gianniou DD, Sklirou AD, Papadimitriou MA, Pilala KM, Stravodimos K, Avgeris M, Scorilas A, Trougakos IP., Free PMC Article | 02/16/2023 |
| Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6. | Molecular chaperone HspB2 inhibited pancreatic cancer cell proliferation via activating p53 downstream gene RPRM, BAI1, and TSAP6.
Yu Z, Wang H, Fang Y, Lu L, Li M, Yan B, Nie Y, Teng C. | 06/19/2021 |
| HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27. | HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27.
Yao K, He L, Gan Y, Liu J, Tang J, Long Z, Tan J., Free PMC Article | 02/27/2021 |
| HSPB2 appeared to be epigenetically regulated by non-CpGs island methylation and was associated with temozolomide resistance in glioblastomas cell lines. | Novel predictive epigenetic signature for temozolomide in non-G-CIMP glioblastomas.
Yin AA, He YL, Etcheverry A, Liu YH, Aubry M, Barnholtz-Sloan J, Liu BL, Mosser J, Lu ZF, Zhang X., Free PMC Article | 03/21/2020 |
| in differentiating myoblasts, nuclear HSPB2 compartments sequester lamin A. | Aberrant Compartment Formation by HSPB2 Mislocalizes Lamin A and Compromises Nuclear Integrity and Function.
Morelli FF, Verbeek DS, Bertacchini J, Vinet J, Mediani L, Marmiroli S, Cenacchi G, Nasi M, De Biasi S, Brunsting JF, Lammerding J, Pegoraro E, Angelini C, Tupler R, Alberti S, Carra S., Free PMC Article | 05/5/2018 |
| HSPB2 competes with HSPB8 for binding to BAG3. In contrast, HSPB3 negatively regulates HSPB2 association with BAG3. | An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8.
Morelli FF, Mediani L, Heldens L, Bertacchini J, Bigi I, Carrà AD, Vinet J, Carra S., Free PMC Article | 03/24/2018 |
| Three of the differentially expressed heat-schock proteins, HSP90A, HSPB1, and HSPB2, are up-regulated in giant cell tumor of bone patients. | Potential role of heat-shock proteins in giant cell tumors.
Chen JT, Younusi A, Cao L, Tian Z, Zhou YJ, Song XH. | 10/29/2016 |
| HspB2 has roles in maintaining ATP levels and as well as chaperone-dependent functions for metabolic homeostasis | Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.
Grose JH, Langston K, Wang X, Squires S, Mustafi SB, Hayes W, Neubert J, Fischer SK, Fasano M, Saunders GM, Dai Q, Christians E, Lewandowski ED, Ping P, Benjamin IJ., Free PMC Article | 06/11/2016 |
| Results suggest a limited function of alphaB-crystallin and HSP27 in preventing abnormal tau protein deposition in glial cells and neurons; in addition, the expression of alphaB-crystallin phosphorylated at Ser59 may act as a protective factor in glial cells. | αB-crystallin and HSP27 in glial cells in tauopathies.
López-González I, Carmona M, Arregui L, Kovacs GG, Ferrer I. | 08/8/2015 |
| These findings provide novel insights into the role of p53 as a regulator of bidirectional gene pair HspB2/alpha B-crystallin-mediated ROS and the Warburg effect | As a novel p53 direct target, bidirectional gene HspB2/αB-crystallin regulates the ROS level and Warburg effect.
Liu S, Yan B, Lai W, Chen L, Xiao D, Xi S, Jiang Y, Dong X, An J, Chen X, Cao Y, Tao Y. | 09/13/2014 |
| Study shows that HspB2 oligomers exchange subunits. | HspB2/myotonic dystrophy protein kinase binding protein (MKBP) as a novel molecular chaperone: structural and functional aspects.
Prabhu S, Raman B, Ramakrishna T, Rao ChM., Free PMC Article | 06/16/2012 |
| promoter methylation of heat shock protein B2 is a novel molecular biomarker in human esophageal squamous cell carcinoma | Promoter methylation of heat shock protein B2 in human esophageal squamous cell carcinoma.
Chang X, Yamashita K, Sidransky D, Kim MS., Free PMC Article | 08/27/2011 |
| Reveal a novel function of HspB2 as an anti-apoptotic protein that negatively regulates apical caspase 3/8 activation in the extrinsic apoptotic pathway. | The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway.
Oshita SE, Chen F, Kwan T, Yehiely F, Cryns VL., Free PMC Article | 02/26/2011 |
| Hsp27, but not the classic Hsp60 and Hsp70, may be associated with the development bronchiolitis obliterans syndrome. | The role of heat shock protein 27 in bronchiolitis obliterans syndrome after lung transplantation.
Wood KL, Nunley DR, Moffatt-Bruce S, Pope-Harman A, Huang Q, Shamo EN, Phillips GS, Baran C, Batra S, Marsh CB, Doseff AI., Free PMC Article | 11/27/2010 |
| Sodium salicylate can induce the expression of HSP27 in human lens epithelial cells. | Effects of mitogen-activated protein kinase signal pathway on heat shock protein 27 expression in human lens epithelial cells exposed to sodium salicylate in vitro.
Wang Z, Gao R, Huang Y, Tian B, Zhou Y. | 10/23/2010 |
| Both heat and BPDE can induce the expressions of Hsp27 and Hsp70 in A549 cells. | [Effect of heat and BPDE on the expression of Hsp27 and Hsp70 in A549 cell line].
Duan YY, Long ZY, Niu PY, Wu TC. | 08/2/2010 |
| analysis of CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients | CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients.
Liebhardt S, Ditsch N, Nieuwland R, Rank A, Jeschke U, Von Koch F, Friese K, Toth B. | 07/19/2010 |
| HSP27 is linked to multi-drug resistance in cell line HepG2/VCR. | [Heat-shock protein 27 linked to multi-drug resistance in human hepatic cancer cell lines].
Peng SF, Fu L, Tan DM. | 07/12/2010 |
| The abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with lymph node metastasis in colorectal cancer. | [Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer].
Pei HP, Ge H, Jiang R, Zhu H. | 06/14/2010 |
| 5-fluorouracil & carboplatin specifically induce expression of Hsp27 in hepatoma cells. siRNA knockdown of Hsp27 diminishes survival of drug-exposed cells. | Inhibition of Hsp27 and Hsp40 potentiates 5-fluorouracil and carboplatin mediated cell killing in hepatoma cells.
Sharma A, Upadhyay AK, Bhat MK. | 05/31/2010 |
| HSP27 confers reresistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E | Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E.
Andrieu C, Taieb D, Baylot V, Ettinger S, Soubeyran P, De-Thonel A, Nelson C, Garrido C, So A, Fazli L, Bladou F, Gleave M, Iovanna JL, Rocchi P. | 05/3/2010 |
| PM induces ROS generation in human lung endothelium, resulting in oxidative stress-mediated EC barrier disruption via p38 MAPK- and HSP27-dependent pathways. | Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways.
Wang T, Chiang ET, Moreno-Vinasco L, Lang GD, Pendyala S, Samet JM, Geyh AS, Breysse PN, Chillrud SN, Natarajan V, Garcia JG., Free PMC Article | 04/12/2010 |