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    HSPA5 heat shock protein family A (Hsp70) member 5 [ Homo sapiens (human) ]

    Gene ID: 3309, updated on 15-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    QRICH1 suppresses pediatric T-cell acute lymphoblastic leukemia by inhibiting GRP78.

    QRICH1 suppresses pediatric T-cell acute lymphoblastic leukemia by inhibiting GRP78.
    Zhao J, Kang M, Li H, Rong L, Wang Y, Xue Y, Yao Y, Fang Y., Free PMC Article

    10/11/2024
    Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches.

    Targeting PERK and GRP78 in colorectal cancer: Genetic insights and novel therapeutic approaches.
    Mafi S, Dehghani M, Khalvati B, Abidi H, Ghorbani M, Jalali P, Whichelo R, Salehi Z, Markowska A, Reyes A, Pecic S, Łos MJ, Ghavami S, Nikseresht M.

    09/23/2024
    Grp78 regulates NLRP3 inflammasome and participates in Sjogren's syndrome.

    Grp78 regulates NLRP3 inflammasome and participates in Sjogren's syndrome.
    He J, Xu M, Chen Y, Wu S.

    09/9/2024
    Unfolded protein response markers Grp78 and eIF2alpha are upregulated with increasing alpha-synuclein levels in Lewy body disease.

    Unfolded protein response markers Grp78 and eIF2alpha are upregulated with increasing alpha-synuclein levels in Lewy body disease.
    Hrabos D, Poggiolini I, Civitelli L, Galli E, Esapa C, Saarma M, Lindholm P, Parkkinen L.

    08/22/2024
    Role of the GRP78-c-Src signaling pathway on osteoblast differentiation of periodontal ligament fibroblasts induced by cyclic mechanical stretch.

    Role of the GRP78-c-Src signaling pathway on osteoblast differentiation of periodontal ligament fibroblasts induced by cyclic mechanical stretch.
    Hu J, Cui Z, Huang K, Su R, Zhao S., Free PMC Article

    08/12/2024
    GRP78 recognizes EV-F 3D protein and activates NF-kappaB to repress virus replication by interacting with CHUK/IKBKB.

    GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB.
    Chang X, Guo Y, Zhang Q, Zheng X, Cui X, Hu J, Zhang Z, Zhang F, Wang X., Free PMC Article

    07/17/2024
    GRP78 Downregulation in Keratinocytes Promotes Skin Inflammation through the Recruitment and Activation of CCR6[+] IL-17A-Producing gammadelta T Cells.

    GRP78 Downregulation in Keratinocytes Promotes Skin Inflammation through the Recruitment and Activation of CCR6(+) IL-17A-Producing γδ T Cells.
    Zhao L, Li J, Jiang B, Yang J, Lan J, Li D, Wen J, Xia Y, Nie W, Wang Z, Lv Y, Zeng F, Li Y, Shen G, Lei P, Tao J.

    07/11/2024
    SARS-CoV-2 Spike Protein-Derived Cyclic Peptides as Modulators of Spike Interaction with GRP78.

    SARS-CoV-2 Spike Protein-Derived Cyclic Peptides as Modulators of Spike Interaction with GRP78.
    Johnson N, Pattinson C, Burgoyne K, Hijazi K, Houssen WE, Milne BF.

    06/28/2024
    Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus.

    Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus.
    Klyosova EY, Azarova YE, Ilyina EA, Goryainova NV, Polonikov AV.

    06/17/2024
    A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis.

    A study on expression of GRP78 and CHOP in neutrophil endoplasmic reticulum and their relationship with neutrophil apoptosis in the development of sepsis.
    Zhao J, Yang P, Lu LI, Yi T, Li Y, Mao W, Zhou Q, Lin KE.

    06/13/2024
    The interaction of GRP78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner.

    The interaction of GRP78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner.
    Sornjai W, Promma P, Priewkhiew S, Ramphan S, Jaratsittisin J, Jinagool P, Wikan N, Greenwood M, Murphy D, Smith DR., Free PMC Article

    05/23/2024
    Prediction of the binding location between the nuclear inhibitor of DNA binding and differentiation 2 (ID2) and HSPA5.

    Prediction of the binding location between the nuclear inhibitor of DNA binding and differentiation 2 (ID2) and HSPA5.
    Elfiky AA.

    03/15/2024
    Structural basis for the mechanism of interaction of SARS-CoV-2 B.1.640.2 variant RBD with the host receptors hACE2 and GRP78.

    Structural basis for the mechanism of interaction of SARS-CoV-2 B.1.640.2 variant RBD with the host receptors hACE2 and GRP78.
    Shafiq A, Khalid U, Abdur Rehman U, Abdullah Almuqri E, Muddassir M, Ahmad S, Khan MI, Khan A, Wei DQ.

    02/22/2024
    GRP78 promotes bone metastasis of prostate cancer by regulating bone microenvironment through Sonic hedgehog signaling.

    GRP78 promotes bone metastasis of prostate cancer by regulating bone microenvironment through Sonic hedgehog signaling.
    Yang M, Weng K, Guo Y, Huang L, Chen J, Lu H.

    02/9/2024
    lncRNA HOTAIRM1 Activated by HOXA4 Drives HUVEC Proliferation Through Direct Interaction with Protein Partner HSPA5.

    lncRNA HOTAIRM1 Activated by HOXA4 Drives HUVEC Proliferation Through Direct Interaction with Protein Partner HSPA5.
    Zhou Y, Wu Q, Long X, He Y, Huang J., Free PMC Article

    02/1/2024
    Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma.

    Nuclear GRP78 Promotes Metabolic Reprogramming and Therapeutic Resistance in Pancreatic Ductal Adenocarcinoma.
    Zhao T, Jiang T, Li X, Chang S, Sun Q, Kong F, Kong X, Wei F, He J, Hao J, Xie K.

    12/21/2023
    Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP.

    Mechanistic characterization of disulfide bond reduction of an ERAD substrate mediated by cooperation between ERdj5 and BiP.
    Cai X, Ito S, Noi K, Inoue M, Ushioda R, Kato Y, Nagata K, Inaba K., Free PMC Article

    12/6/2023
    Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group.

    Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group.
    Hoff FW, Qiu Y, Brown BD, Gerbing RB, Leonti AR, Ries RE, Gamis AS, Aplenc R, Kolb EA, Alonzo TA, Meshinchi S, Jenkins GN, Horton TM, Kornblau SM.,

    12/1/2023
    NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.

    NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5.
    Gurri S, Siegenthaler B, Cangkrama M, Restivo G, Huber M, Saliba J, Dummer R, Blank V, Hohl D, Werner S., Free PMC Article

    11/14/2023
    The chaperone protein GRP78 released from MPN cells increases the expression of lysyl oxidase in a human stromal cell line.

    The chaperone protein GRP78 released from MPN cells increases the expression of lysyl oxidase in a human stromal cell line.
    Nakajima K, Suzuki M, Kawashima I, Koshiisi M, Kumagai T, Yamamoto T, Tanaka M, Kirito K.

    11/7/2023
    Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer.

    Research progress on the GRP78 gene in the diagnosis, treatment and immunity of cervical cancer.
    Bai Y, Wang W, Cheng Y, Yang Y., Free PMC Article

    10/30/2023
    PLXNC1 interference alleviates the inflammatory injury, apoptosis and extracellular matrix degradation of IL-1beta-exposed chondrocytes via suppressing GRP78 expression.

    PLXNC1 interference alleviates the inflammatory injury, apoptosis and extracellular matrix degradation of IL-1β-exposed chondrocytes via suppressing GRP78 expression.
    Meng N, Mao L, Jiang Q, Yuan J, Liu L, Wang L., Free PMC Article

    10/30/2023
    EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer.

    EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer.
    Wang Y, Liu Y, Wang C, Kang R, Tang D, Liu J., Free PMC Article

    09/28/2023
    GRP78 is Overexpressed in Non-small Cell Lung Cancer Tissues and is Associated with High VEGF Expression in Squamous Cell Carcinoma: A Pilot Study.

    GRP78 is Overexpressed in Non-small Cell Lung Cancer Tissues and is Associated with High VEGF Expression in Squamous Cell Carcinoma: A Pilot Study.
    Al-Keilani M, Alqudah MA, Almomani B, Alrjoub MM, Shhabat BA, Alzoubi K.

    08/30/2023
    Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review.

    Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review.
    Akinyemi AO, Simpson KE, Oyelere SF, Nur M, Ngule CM, Owoyemi BCD, Ayarick VA, Oyelami FF, Obaleye O, Esoe DP, Liu X, Li Z., Free PMC Article

    08/28/2023
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