| The human testis-enriched HSPA2 interacts with HIF-1alpha in epidermal keratinocytes, yet HIF-1alpha stability and HIF-1-dependent gene expression rely on the HSPA (HSP70) activity. | The human testis-enriched HSPA2 interacts with HIF-1α in epidermal keratinocytes, yet HIF-1α stability and HIF-1-dependent gene expression rely on the HSPA (HSP70) activity.
Sojka DR, Gogler A, Kania D, Vydra N, Wiecha K, Adamiec-Organiściok M, Wilk A, Chumak V, Matyśniak D, Scieglinska D. | 06/6/2024 |
| HSPA1A, HSPA2, and HSPA8 Are Potential Molecular Biomarkers for Prognosis among HSP70 Family in Alzheimer's Disease. | HSPA1A, HSPA2, and HSPA8 Are Potential Molecular Biomarkers for Prognosis among HSP70 Family in Alzheimer's Disease.
Dong Y, Li T, Ma Z, Zhou C, Wang X, Li J., Free PMC Article | 10/29/2022 |
| Paternal factors in recurrent pregnancy loss: an insight through analysis of non-synonymous single-nucleotide polymorphism in human testis-specific chaperone HSPA2 gene. | Paternal factors in recurrent pregnancy loss: an insight through analysis of non-synonymous single-nucleotide polymorphism in human testis-specific chaperone HSPA2 gene.
Mohanty G, Jena SR, Kar S, Samanta L. | 09/24/2022 |
| Tumorigenic and immunological roles of Heat shock protein A2 in pancreatic cancer: a bioinformatics analysis. | Tumorigenic and immunological roles of Heat shock protein A2 in pancreatic cancer: a bioinformatics analysis.
Zhai LL, Qiao PP, Sun YS, Ju TF, Tang ZG. | 06/11/2022 |
| Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis status. | Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis status.
Nowicka-Bauer K, Malcher A, Włoczkowska O, Kamieniczna M, Olszewska M, Kurpisz MK. | 03/12/2022 |
| Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE epsilon2 protective effect in Alzheimer disease. | Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease.
Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR., Free PMC Article | 02/5/2022 |
| Human sperm chaperone HSPA2 distribution during in vitro capacitation. | Human sperm chaperone HSPA2 distribution during in vitro capacitation.
Huerta-Retamal N, Sáez-Espinosa P, Robles-Gómez L, Avilés M, Romero A, Aizpurua J, Gómez-Torres MJ. | 11/6/2021 |
| RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2. | RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2.
Yang YL, Zhang Y, Li DD, Zhang FL, Liu HY, Liao XH, Xie HY, Lu Q, Zhang L, Hong Q, Dong WJ, Li DQ, Shao ZM., Free PMC Article | 07/3/2021 |
| Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection. | Assessing the potential of HSPA2 and ADAM2 as two biomarkers for human sperm selection.
Heidari M, Darbani S, Darbandi M, Lakpour N, Fathi Z, Zarnani AH, Zeraati H, Akhondi MM, Sadeghi MR. | 05/8/2021 |
| Functional redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma (NSCLC); an implication for NSCLC treatment. | Functional redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma (NSCLC); an implication for NSCLC treatment.
Sojka DR, Gogler-Pigłowska A, Vydra N, Cortez AJ, Filipczak PT, Krawczyk Z, Scieglinska D., Free PMC Article | 10/31/2020 |
| An increased level of the HSP70 gene expression in peripheral blood leukocytes in mothers with a life-threatening disease of their child indicates the damaging effect of long-lasting psychoemotional stress at the cellular level and activation of the protective reaction mediated by HSP70. | [Study of heat shock protein gene 70 (HSP70) expression and its polymorphous marker (+ 1267A> G) in women under exposure to a long-term stress.].
Chukaeva II, Gankovskaya LV, Plotnikova NA, Orlova NV, Ponasenko OA, Svitich OA, Spiryakina YG. | 07/20/2019 |
| HSPA2 may play an important role in tumor progression, and serve as a potential biomarker for the prediction of adverse prognosis in pancreatic carcinoma | Overexpressed HSPA2 correlates with tumor angiogenesis and unfavorable prognosis in pancreatic carcinoma.
Zhai LL, Xie Q, Zhou CH, Huang DW, Tang ZG, Ju TF. | 03/24/2018 |
| HSPA2 appears to be necessary for controlling development of properly stratified epidermis and thus for maintenance of skin homeostasis. | Novel role for the testis-enriched HSPA2 protein in regulating epidermal keratinocyte differentiation.
Gogler-Pigłowska A, Klarzyńska K, Sojka DR, Habryka A, Głowala-Kosińska M, Herok M, Kryj M, Halczok M, Krawczyk Z, Scieglinska D. | 12/16/2017 |
| This study showed that a strong association between rs2227956 polymorphism and MS risk, which is independent from the association with HSP70-2 rs1061581, and a significant link between hsp70-hom protein expression and multiple sclerosis severity. | Heat shock protein 70-hom gene polymorphism and protein expression in multiple sclerosis.
Boiocchi C, Monti MC, Osera C, Mallucci G, Pistono C, Ferraro OE, Nosari G, Romani A, Cuccia M, Govoni S, Pascale A, Montomoli C, Bergamaschi R. | 08/19/2017 |
| The data suggest that seminal plasma HSPA2 Cell-free mRNA is different between asthenozoospermic and normozoospermic individuals and it might be an indicator for semen quality. | Seminal plasma HSPA2 mRNA content is associated with semen quality.
Tian Y, Li L, Zhang F, Xu J., Free PMC Article | 03/18/2017 |
| ACE and PDIA6 were identified as potential HSPA2-interacting proteins; this assemblage resides in membrane raft microdomains located in the peri-acrosomal region of the sperm head. | Heat Shock Protein member A2 forms a stable complex with angiotensin converting enzyme and protein disulfide isomerase A6 in human spermatozoa.
Bromfield EG, McLaughlin EA, Aitken RJ, Nixon B. | 10/22/2016 |
| Results suggest that overexpression of HSPA2 in pancreatic cancer is associated with aggressive progression and poor prognosis and that HSPA2 may be served as a prognostic marker. | Expression and clinical significance of HSPA2 in pancreatic ductal adenocarcinoma.
Zhang H, Gao H, Liu C, Kong Y, Wang C, Zhang H., Free PMC Article | 05/21/2016 |
| we consider the evidence supporting the role of HSPA2 in sperm function and explore the potential mechanisms by which it is depleted in the spermatozoa of infertile patients--{REVIEW} | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition.
Nixon B, Bromfield EG, Dun MD, Redgrove KA, McLaughlin EA, Aitken RJ., Free PMC Article | 03/26/2016 |
| HSPA2 expression increased under conditions that stimulated HIF-1alpha activity, whereas inhibition of HIF-1alpha abrogated hypoxia-induced up-regulation of HSPA2 expression | Cell type-dependent modulation of the gene encoding heat shock protein HSPA2 by hypoxia-inducible factor HIF-1: Down-regulation in keratinocytes and up-regulation in HeLa cells.
Habryka A, Gogler-Pigłowska A, Sojka D, Kryj M, Krawczyk Z, Scieglinska D. | 10/31/2015 |
| The fertilization rate with ICSI is associated with HspA2 expression in the testis from which sperm retrieved and the alteration of HspA2 expression has been involved in spermatogenic impairment. | Depression of HspA2 in human testis is associated with spermatogenic impairment and fertilization rate in ICSI treatment for azoospermic individuals.
Tian Y, Zhang F, Zhang X, Li L, Wang L, Shi B, Xu J., Free PMC Article | 08/1/2015 |
| High expression of HSPA2 is associated with hepatocellular carcinoma. | Expression of HSPA2 in human hepatocellular carcinoma and its clinical significance.
Fu Y, Zhao H, Li XS, Kang HR, Ma JX, Yao FF, Du N. | 04/18/2015 |
| HSP70-2 +1267 polymorphism may influence the risk of coronary artery disease (CAD) in Iranian population, however further studies are needed to clarify the role of other HSP70-2 gene polymorphisms in the pathogenesis of the CAD. | Association of heat shock protein70-2 (HSP70-2) gene polymorphism with coronary artery disease in an Iranian population.
Mardan-Nik M, Pasdar A, Jamialahmadi K, Biabangard-Zak A, Mirhafez SR, Ghalandari M, Tajfard M, Mohebati M, Esmaily H, Ferns GA, Ghayour-Mobarhan M. | 11/22/2014 |
| High HSPA2 expression is associated with non-small cell lung carcinoma. | HSPA2 is expressed in human tumors and correlates with clinical features in non-small cell lung carcinoma patients.
Scieglinska D, Gogler-Piglowska A, Butkiewicz D, Chekan M, Malusecka E, Harasim J, Habryka A, Krawczyk Z. | 08/23/2014 |
| Genotype analysis of HSP70-2 (+1267 A/G) polymorphism revealed a significant association between the minor allele G and presence of Multiple Sclerosis | Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?
Boiocchi C, Osera C, Monti MC, Ferraro OE, Govoni S, Cuccia M, Montomoli C, Pascale A, Bergamaschi R. | 05/3/2014 |
| findings show polymorphisms of HSP70 genes are associated with the development of gastric cancer and duodenal ulcers in a population at high risk for gastric cancer in Costa Rica | Polymorphisms in genes coding for HSP-70 are associated with gastric cancer and duodenal ulcer in a population at high risk of gastric cancer in Costa Rica.
Ferrer-Ferrer M, Malespín-Bendaña W, Ramírez V, González MI, Carvajal A, Une C. | 03/1/2014 |