| Novel insights into the post-translational modifications of Ydj1/DNAJA1 co-chaperones. | Novel insights into the post-translational modifications of Ydj1/DNAJA1 co-chaperones.
Mitchem MM, Shrader C, Abedi E, Truman AW., Free PMC Article | 03/6/2024 |
| DNAJA1 promotes proliferation and metastasis of breast cancer by activating mutant P53/NF-kappaB pathway. | DNAJA1 promotes proliferation and metastasis of breast cancer by activating mutant P53/NF-κB pathway.
Wu J, Yang Q, Zhu Y, Xia T, Yi L, Wang J, Ren X. | 12/5/2023 |
| Leveraging the Structure of DNAJA1 to Discover Novel Potential Pancreatic Cancer Therapies. | Leveraging the Structure of DNAJA1 to Discover Novel Potential Pancreatic Cancer Therapies.
Roth HE, De Lima Leite A, Palermo NY, Powers R., Free PMC Article | 11/5/2022 |
| High expression of DNAJA1 (HDJ2) predicts unfavorable survival outcomes in breast cancer. | High expression of DNAJA1 (HDJ2) predicts unfavorable survival outcomes in breast cancer.
Ileri FC, Acun T. | 03/26/2022 |
| DNAJA1 promotes cancer metastasis through interaction with mutant p53. | DNAJA1 promotes cancer metastasis through interaction with mutant p53.
Kaida A, Yamamoto S, Parrales A, Young ED, Ranjan A, Alalem MA, Morita KI, Oikawa Y, Harada H, Ikeda T, Thomas SM, Diaz FJ, Iwakuma T., Free PMC Article | 01/8/2022 |
| Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1. | Cereblon Regulates the Proteotoxicity of Tau by Tuning the Chaperone Activity of DNAJA1.
Akber U, Jo H, Jeon S, Yang SJ, Bong S, Lim S, Kim YK, Park ZY, Park CS., Free PMC Article | 11/27/2021 |
| DNAJA1 Dysregulates Metabolism Promoting an Antiapoptotic Phenotype in Pancreatic Ductal Adenocarcinoma. | DNAJA1 Dysregulates Metabolism Promoting an Antiapoptotic Phenotype in Pancreatic Ductal Adenocarcinoma.
Roth HE, Bhinderwala F, Franco R, Zhou Y, Powers R., Free PMC Article | 08/14/2021 |
| Identification of a druggable protein-protein interaction site between mutant p53 and its stabilizing chaperone DNAJA1. | Identification of a druggable protein-protein interaction site between mutant p53 and its stabilizing chaperone DNAJA1.
Tong X, Xu D, Mishra RK, Jones RD, Sun L, Schiltz GE, Liao J, Yang GY., Free PMC Article | 08/7/2021 |
| HSP4 triggers epithelial-mesenchymal transition and promotes motility capacities of hepatocellular carcinoma cells via activating AKT. | HSP4 triggers epithelial-mesenchymal transition and promotes motility capacities of hepatocellular carcinoma cells via activating AKT.
Ma P, Tang WG, Hu JW, Hao Y, Xiong LK, Wang MM, Liu H, Bo WH, Yu KH. | 07/17/2021 |
| Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles. | Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles.
Gu J, Liu Z, Zhang S, Li Y, Xia W, Wang C, Xiang H, Liu Z, Tan L, Fang Y, Liu C, Li D., Free PMC Article | 02/2/2021 |
| Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation. | Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation.
Rodríguez-González C, Lin S, Arkan S, Hansen C., Free PMC Article | 12/5/2020 |
| High level of DNAJA1 predicted poor prognosis for colorectal cancer (CRC) patients. Its expression was highly linked with E2F1 and CDC45 in CRC tissues. More importantly, KNK437 significantly suppressed the growth of DNAJA1 expressing tumor in vivo | KNK437 restricts the growth and metastasis of colorectal cancer via targeting DNAJA1/CDC45 axis.
Yang S, Ren X, Liang Y, Yan Y, Zhou Y, Hu J, Wang Z, Song F, Wang F, Liao W, Liao W, Ding Y, Liang L. | 04/18/2020 |
| analysis of a a biallelic truncating variant in DNAJA1 gene (c.511C>T p.(Gln171*) in a multiplex Saudi consanguineous family | Truncating biallelic variant in DNAJA1, encoding the co-chaperone Hsp40, is associated with intellectual disability and seizures.
Alsahli S, Alfares A, Guzmán-Vega FJ, Arold ST, Ba-Armah D, Al Mutairi F. | 01/11/2020 |
| DjA1 interacts with GRASP65 to enhance Golgi structure formation through the promotion of GRASP65 trans-oligomerization. | DjA1 maintains Golgi integrity via interaction with GRASP65.
Li J, Tang D, Ireland SC, Wang Y., Free PMC Article | 06/29/2019 |
| that DNAJA1 controls the fate of misfolded stabilization of mutant p53 | DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.
Parrales A, Ranjan A, Iyer SV, Padhye S, Weir SJ, Roy A, Iwakuma T., Free PMC Article | 05/27/2017 |
| Therefore, we propose that DnaJA1 is co-opted by the influenza A virus to enter the nucleus and to enhance its RNA polymerase activity in an Hsp70 cochaperone-independent manner. | DnaJA1/Hsp40 is co-opted by influenza A virus to enhance its viral RNA polymerase activity.
Cao M, Wei C, Zhao L, Wang J, Jia Q, Wang X, Jin Q, Deng T., Free PMC Article | 01/24/2015 |
| structure and function of human DNAJA1 and its relationship to pancreatic cancer | Structure and function of human DnaJ homologue subfamily a member 1 (DNAJA1) and its relationship to pancreatic cancer.
Stark JL, Mehla K, Chaika N, Acton TB, Xiao R, Singh PK, Montelione GT, Powers R., Free PMC Article | 04/26/2014 |
| we combined the Hsp70-NEF pairs with cochaperones of the J protein family (DnaJA1, DnaJA2, DnaJB1, and DnaJB4) to generate 16 permutations. | Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
Rauch JN, Gestwicki JE., Free PMC Article | 03/22/2014 |
| Moreover, the levels of DnaJA1 and Hsp70 seem to play against each other with regard to tau: as DnaJA1 levels increase, tau levels are reduced, but this can be prevented if Hsp70 levels are simultaneously induced. | DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.
Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA., Free PMC Article | 10/6/2012 |
| Hdj2 directly associates with Japanese encephalitis virus nonstructural protein NS5 and facilitates viral replication. | DnaJ homolog Hdj2 facilitates Japanese encephalitis virus replication.
Wang RY, Huang YR, Chong KM, Hung CY, Ke ZL, Chang RY., Free PMC Article | 01/14/2012 |
| Observational study of gene-disease association. (HuGE Navigator) | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. | 12/5/2010 |
| Hsc70 and a dimer of DjA1 independently bind to an unfolded protein | Multiple molecules of Hsc70 and a dimer of DjA1 independently bind to an unfolded protein.
Terada K, Oike Y., Free PMC Article | 06/28/2010 |
| Hsp40 type 1 chaperones DJA1 (DNAJA1/Hdj2) and DJA2 (DNAJA2) as key modulators of hERG degradation | Hsp40 chaperones promote degradation of the HERG potassium channel.
Walker VE, Wong MJ, Atanasiu R, Hantouche C, Young JC, Shrier A., Free PMC Article | 03/1/2010 |
| DJA1 was inhibitory of refolding with DJA2 and Hsc70. | Functional divergence between co-chaperones of Hsc70.
Tzankov S, Wong MJ, Shi K, Nassif C, Young JC., Free PMC Article | 01/21/2010 |
| Multiple tissue polymerase chain reaction (PCR) results showed that nDnaJA1 expressed highly in testis and lung but low in thymus, prostate, colon and liver | Expression of a novel DnaJA1 alternative splicing in human testis and sperm.
Hu Y, Zhou Z, Huang X, Xu M, Lu L, Xu Z, Li J, Sha J. | 01/21/2010 |