| FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation. | FoxO6-Mediated TXNIP Induces Lipid Accumulation in the Liver through NLRP3 Inflammasome Activation.
Kim ME, Lee JS, Kim TW, Park MH, Kim DH., Free PMC Article | 03/1/2024 |
| Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo. | Role and mechanism underlying FoxO6 in skeletal muscle in vitro and in vivo.
Zhang L, Zhang Y, Zhou M, Wang S, Li T, Hu Z, Jin C. | 12/11/2021 |
| Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation. | Interaction between CHOP and FoxO6 promotes hepatic lipid accumulation.
Kim DH, Kim BM, Chung KW, Choi YJ, Yu BP, Chung HY., Free PMC Article | 08/7/2021 |
| FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity. | FoxO6 inhibits melanogenesis partly by elevating intracellular antioxidant capacity.
Moon KM, Lee B, Kim DH, Chung HY., Free PMC Article | 07/10/2021 |
| we assume that FoxO6-mediated IL-1beta is involved in hepatic inflammation and insulin resistance via TF/PAR2 pathway in the liver. | FoxO6-mediated IL-1β induces hepatic insulin resistance and age-related inflammation via the TF/PAR2 pathway in aging and diabetic mice.
Kim DH, Lee B, Lee J, Kim ME, Lee JS, Chung JH, Yu BP, Dong HH, Chung HY., Free PMC Article | 02/29/2020 |
| data indicate that FoxO6 depletion protected against diet-induced glucose intolerance and insulin resistance by attenuating hepatic gluconeogenesis and curbing macrophage infiltration in liver and adipose tissues in mice. | Forkhead Box O6 (FoxO6) Depletion Attenuates Hepatic Gluconeogenesis and Protects against Fat-induced Glucose Disorder in Mice.
Calabuig-Navarro V, Yamauchi J, Lee S, Zhang T, Liu YZ, Sadlek K, Coudriet GM, Piganelli JD, Jiang CL, Miller R, Lowe M, Harashima H, Dong HH., Free PMC Article | 08/29/2015 |
| FoxO6 is an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production | FoxO6 integrates insulin signaling with MTP for regulating VLDL production in the liver.
Kim DH, Zhang T, Lee S, Calabuig-Navarro V, Yamauchi J, Piccirillo A, Fan Y, Uppala R, Goetzman E, Dong HH., Free PMC Article | 05/24/2014 |
| Studies indicate that FoxO6 is produced in the liver of both rodents and humans. | FoxO6 in glucose metabolism (FoxO6).
Kim DH, Zhang T, Lee S, Dong HH., Free PMC Article | 03/15/2014 |
| FoxO6 represses the expression of PGC-1alpha via direct binding to an upstream A/T-rich element (AAGATATCAAAACA,-2228-2215) in the PGC-1alpha promoter. | FoxO6 and PGC-1α form a regulatory loop in myogenic cells.
Chung SY, Huang WC, Su CW, Lee KW, Chi HC, Lin CT, Chen ST, Huang KM, Tsai MS, Yu HP, Chen SL., Free PMC Article | 01/18/2014 |
| FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus | FoxO6 regulates memory consolidation and synaptic function.
Salih DA, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE, Ucar D, Devarajan K, Cole CJ, Madison DV, Shamloo M, Butte AJ, Bonni A, Josselyn SA, Brunet A., Free PMC Article | 02/9/2013 |
| Central FoxO3a and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging. | Central FoxO3a and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging.
Zemva J, Schilbach K, Stöhr O, Moll L, Franko A, Krone W, Wiesner RJ, Schubert M. | 10/27/2012 |
| investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in liver orchestrates insulin regulation of gluconeogenesis. FoxO6 appears to be ubiquitously expressed in mouse tissues. | FoxO6 integrates insulin signaling with gluconeogenesis in the liver.
Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH., Free PMC Article | 12/17/2011 |
| FoxO factors mediate Myc-induced Arf expression and provide direct genetic evidence for their tumor-suppressive capacity. | FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.
Bouchard C, Lee S, Paulus-Hock V, Loddenkemper C, Eilers M, Schmitt CA., Free PMC Article | 01/21/2010 |
| cloning and characterization; structural and functional properties related to gene regulation | FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics.
Jacobs FM, van der Heide LP, Wijchers PJ, Burbach JP, Hoekman MF, Smidt MP. | 01/21/2010 |