| miR-330-5p Suppress Cell Growth and Invasion via Disrupting HSF4-mediated MACC1/STAT3 Pathway in Colorectal Cancer. | miR-330-5p Suppress Cell Growth and Invasion via Disrupting HSF4-mediated MACC1/STAT3 Pathway in Colorectal Cancer.
Liu J, Yue K, Yang J, Bi C, Zhang Y, Zhang W. | 03/4/2024 |
| Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts. | Variants in PAX6, PITX3 and HSF4 causing autosomal dominant congenital cataracts.
Berry V, Ionides A, Pontikos N, Moore AT, Quinlan RA, Michaelides M., Free PMC Article | 07/30/2022 |
| The results expand the spectrum of HSF4 mutations causing congenital cataracts. | Novel mutations in HSF4 cause congenital cataracts in Chinese families.
Cao Z, Zhu Y, Liu L, Wu S, Liu B, Zhuang J, Tong Y, Chen X, Xie Y, Nie K, Lu C, Ma X, Yang J., Free PMC Article | 04/20/2019 |
| Ectopic UAP56 upregulated HSF4-controlled HSP25 and alpha B-crystallin proteins expression, while knocking down UAP56 by shRNA reversed it. | Heat shock factor 4 regulates the expression of HSP25 and alpha B-crystallin by associating with DEXD/H-box RNA helicase UAP56.
Cui X, Han W, Li J, Feng R, Zhou Z, Han J, Li M, Wang S, Zhang W, Lei Q, Zhang J, Liu Y, Hu Y., Free PMC Article | 01/26/2019 |
| We have identified a novel mutation in HSF4 in a large British pedigree causing dominant congenital lamellar cataract | A novel missense mutation in HSF4 causes autosomal-dominant congenital lamellar cataract in a British family.
Berry V, Pontikos N, Moore A, Ionides ACW, Plagnol V, Cheetham ME, Michaelides M., Free PMC Article | 12/22/2018 |
| High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer. | High HSF4 expression is an independent indicator of poor overall survival and recurrence free survival in patients with primary colorectal cancer.
Yang Y, Jin L, Zhang J, Wang J, Zhao X, Wu G, Yao H, Zhang Z. | 07/7/2018 |
| In the cultured human lens epithelial cells, HSF4 could stabilize and retain p53 in the nucleus to activate its target genes such as fas cell surface death receptor (Fas) and Bcl-2-associated X apoptosis regulator (Bax). | HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.
Gao M, Huang Y, Wang L, Huang M, Liu F, Liao S, Yu S, Lu Z, Han S, Hu X, Qu Z, Liu X, Assefa Yimer T, Yang L, Tang Z, Li DW, Liu M., Free PMC Article | 06/9/2018 |
| HMOX-1, an anti-oxidase, is a bona fide transcriptional target gene of HSF4 in HLECs (human lens epithelial cells). HSF4 directly binds to the HSE element in HMOX-1 promoter to mediate its mRNA transcription and protein accumulation. | HSF4 transcriptional regulates HMOX-1 expression in HLECs.
Liao S, Qu Z, Li L, Zhou B, Gao M, Huang M, Li D. | 04/7/2018 |
| report on a novel homozygous HSF4 mutation (c.521T>C, p.Leu174Pro) in two sibs with congenital cataracts | A novel homozygous mutation in HSF4 causing autosomal recessive congenital cataract.
Behnam M, Imagawa E, Chaleshtori AR, Ronasian F, Salehi M, Miyake N, Matsumoto N. | 02/18/2017 |
| BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination. | BCAS2 interacts with HSF4 and negatively regulates its protein stability via ubiquitination.
Liao S, Du R, Wang L, Qu Z, Cui X, Li C, Liu F, Huang M, Wang J, Chen J, Gao M, Yu S, Tang Z, Li DW, Jiang T, Liu M. | 08/13/2016 |
| HSF4 may work as a switch between lens epithelial cell proliferation and secondary fiber cell differentiation, a process which mainly depends on p53. | HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53.
Huang M, Li D, Huang Y, Cui X, Liao S, Wang J, Liu F, Li C, Gao M, Chen J, Tang Z, Li DW, Liu M. | 09/12/2015 |
| Nuclear HSF2 and HSF4 bound to HSF1 only after heat shock. | Heat shock-induced interactions among nuclear HSFs detected by fluorescence cross-correlation spectroscopy.
Pack CG, Ahn SG. | 09/12/2015 |
| concluded that the new mutation of c.331C>T in HSF4 DNA may be responsible for the autosomal dominant congenital cataract in this family | A novel HSF4 mutation in a Chinese family with autosomal dominant congenital cataract.
Liu L, Zhang Q, Zhou LX, Tang ZH. | 08/8/2015 |
| We found that HSF4 downregulation led to decrease of HIF1alpha mRNA expression | Effect of HSF4b on age related cataract may through its novel downstream target Hif1α.
Chen Y, Wu Q, Miao A, Jiang Y, Wu X, Wang Z, Wu F, Lu Y. | 07/25/2015 |
| HSF4 p.Arg116His recreates the childhood lamellar cataract in mice suggesting that incomplete penetrance associated with early cataracts may not be an absence but a limitation of the detection of the phenotype | HSF4 mutation p.Arg116His found in age-related cataracts and in normal populations produces childhood lamellar cataract in transgenic mice.
Jing Z, Gangalum RK, Bhat AM, Nagaoka Y, Jiang M, Bhat SP., Free PMC Article | 05/16/2015 |
| This is the first report of the novel missense mutation, c.69 G-->T (p. K23N), in exon 3 of the HSF4 locus on 16q21-q22 associated with bilateral congenital cataracts in a Chinese family. | A novel HSF4 gene mutation causes autosomal-dominant cataracts in a Chinese family.
Lv H, Huang C, Zhang J, Liu Z, Zhang Z, Xu H, You Y, Hu J, Li X, Wang W., Free PMC Article | 01/10/2015 |
| the transcriptional activation of HSF4 is mediated by interactions between activator and repressor domains within the C-terminal end. | Functional analysis of HSF4 mutations found in patients with autosomal recessive congenital cataracts.
Merath K, Ronchetti A, Sidjanin DJ., Free PMC Article | 12/14/2013 |
| This comparative analysis with CRYAB and HSP70 demonstrates that differential heat shock response is controlled by cell-type-dependent access of HSF1 and HSF4 to specific promoters, independent of the promoter architecture. | Cell-type-dependent access of HSF1 and HSF4 to αB-crystallin promoter during heat shock.
Jing Z, Gangalum RK, Lee JZ, Mock D, Bhat SP., Free PMC Article | 11/23/2013 |
| HSF4 exerts its function on lens differentiation via positive regulation of DLAD expression. | HSF4 regulates DLAD expression and promotes lens de-nucleation.
Cui X, Wang L, Zhang J, Du R, Liao S, Li D, Li C, Ke T, Li DW, Huang H, Yin Z, Tang Z, Liu M. | 09/21/2013 |
| HSF4 and WRN CNVs might be involved in ARC pathogenesis in the Han Chinese. | Copy number variations of DNA repair genes and the age-related cataract: Jiangsu Eye Study.
Jiang J, Zhou J, Yao Y, Zhu R, Liang C, Jiang S, Yang M, Lu Y, Xing Q, Guan H. | 04/6/2013 |
| Presents the first evidence demonstrating that HSF4 plays a role in DNA damage repair and may contribute a better understanding of congenital cataract formation. | HSF4 is involved in DNA damage repair through regulation of Rad51.
Cui X, Zhang J, Du R, Wang L, Archacki S, Zhang Y, Yuan M, Ke T, Li H, Li D, Li C, Li DW, Tang Z, Yin Z, Liu M. | 01/26/2013 |
| we report the absence of mutations in all studied genes in four families with phenotypes associating cataract, mental retardation and microcephaly. | Absence of mutations in four genes encoding for congenital cataract and expressed in the human brain in Tunisian families with cataract and mental retardation.
Chograni M, Chaabouni M, Mâazoul F, Bouzid H, Kraiem A, Chaabouni HB., Free PMC Article | 03/10/2012 |
| our findings suggest novel mechanisms of HSF2 regulation controlled by HSF4a. | Heat shock factor 4a (HSF4a) represses HSF2 expression and HSF2-mediated transcriptional activity.
Kim SA, Yoon JH, Ahn SG. | 12/10/2011 |
| HSF2 and HSF4 regulate transcription of HIF-1a and that a critical balance between these HSF is required to maintain HIF-a expression in a repressed state. | Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4.
Chen R, Liliental JE, Kowalski PE, Lu Q, Cohen SN. | 08/20/2011 |
| two missense mutations that have been associated with age-related cataract did not or only slightly alter HSF4 activity, implying that other genetic and environmental factors affect the functions of these mutant proteins. | DNA-binding and transcriptional activities of human HSF4 containing mutations that associate with congenital and age-related cataracts.
Enoki Y, Mukoda Y, Furutani C, Sakurai H. | 11/27/2010 |