| Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice. | Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice.
He E, Sui H, Wang H, Zhao X, Guo W, Dai Z, Wu Z, Huang K, Zhao Q. | 07/29/2024 |
| Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways. | Effects of Interleukin-19 overexpression in the medial prefrontal cortex on anxiety-related behaviors, BDNF expression and p38/JNK/ERK pathways.
Jiang Y, Xu L, Cao Y, Meng F, Jiang S, Yang M, Zheng Z, Zhang Y, Yang L, Wang M, Sun G, Liu J, Li C, Cui M. | 06/7/2024 |
| Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid. | Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid.
Nishiyama K, Horikoshi J, Maehara T, Tanaka M, Tanida T, Kawada K, Takeshita S, Ono N, Izawa T, Kuwamura M, Azuma YT. | 06/3/2024 |
| The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety. | The colonic interleukin-19 aggravates the dextran sodium sulfate/stress-induced comorbidities due to colitis and anxiety.
Li Q, Meng F, Ma X, Sun Z, Dai J, Liu J, Li D, Cong P, Xu R, Zhao D, Wang W, Wang D, Liu C, Wang F, Li C, Lian H., Free PMC Article | 03/27/2023 |
| Interleukin 19 suppresses RANKL-induced osteoclastogenesis via the inhibition of NF-kappaB and p38MAPK activation and c-Fos expression in RAW264.7 cells. | Interleukin 19 suppresses RANKL-induced osteoclastogenesis via the inhibition of NF-κB and p38MAPK activation and c-Fos expression in RAW264.7 cells.
Tsubaki M, Takeda T, Matsuda T, Yamamoto Y, Higashinaka A, Yamamoto K, Tsurushima K, Ishizaka T, Nishida S. | 02/5/2022 |
| Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis. | Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis.
Komiya H, Takeuchi H, Ogawa Y, Suzuki K, Ogasawara A, Takahashi K, Azuma YT, Doi H, Tanaka F., Free PMC Article | 01/22/2022 |
| IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism. | IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism.
Azuma YT, Fujita T, Izawa T, Hirota K, Nishiyama K, Ikegami A, Aoyama T, Ike M, Ushikai Y, Kuwamura M, Fujii H, Tsuneyama K., Free PMC Article | 01/22/2022 |
| Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment. | Osteocytes regulate neutrophil development through IL-19: a potent cytokine for neutropenia treatment.
Xiao M, Zhang W, Liu W, Mao L, Yang J, Hu L, Zhang S, Zheng Y, Liu A, Song Q, Li Y, Xiao G, Zou Z, Bai X., Free PMC Article | 12/4/2021 |
| Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation. | Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation.
Horiuchi H, Parajuli B, Komiya H, Ogawa Y, Jin S, Takahashi K, Azuma YT, Tanaka F, Suzumura A, Takeuchi H., Free PMC Article | 07/3/2021 |
| Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation. | Blocking IL-19 Signaling Ameliorates Allergen-Induced Airway Inflammation.
Weng YH, Chen WY, Lin YL, Wang JY, Chang MS., Free PMC Article | 10/3/2020 |
| IL-19 is an atheroprotective cytokine which decreases the abundance of HuR, leading to reduced inflammatory mRNA stability in Ldlr knockout mice. | Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19(-/-)×Ldlr(-/-) Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R).
Ray M, Gabunia K, Vrakas CN, Herman AB, Kako F, Kelemen SE, Grisanti LA, Autieri MV., Free PMC Article | 07/13/2019 |
| Data, including data from studies using knockout mice, suggest that interleukin-19 suppresses hapten-dependent skin inflammation in elicitation phase of contact hypersensitivity. | The Role of Interleukin-19 in Contact Hypersensitivity.
Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT. | 08/25/2018 |
| Attenuated colitis in IL-19-deficient animals was associated with reduced numbers of IL-6-producing macrophages in the inflamed colonic lamina propria. Microbial-driven expression of IL-19 by intestinal macrophages may contribute to the pathogenesis of inflammatory bowel disease. | The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models.
Steinert A, Linas I, Kaya B, Ibrahim M, Schlitzer A, Hruz P, Radulovic K, Terracciano L, Macpherson AJ, Niess JH. | 10/28/2017 |
| IL-19 can promote angiogenesis in the absence of hypoxia by at least two distinct mechanisms: 1) direct effects on vascular cells and 2) indirect effects by stimulation of macrophages. | Interleukin-19 induces angiogenesis in the absence of hypoxia by direct and indirect immune mechanisms.
Kako F, Gabunia K, Ray M, Kelemen SE, England RN, Kako B, Scalia RG, Autieri MV., Free PMC Article | 06/3/2017 |
| IL-19 plays an anti-inflammatory role in the Th2-mediated colitis model. | Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis.
Fujimoto Y, Azuma YT, Matsuo Y, Kuwamura M, Kuramoto N, Miki M, Azuma N, Teramoto M, Nishiyama K, Izawa T, Nakajima H, Takeuchi T. | 02/25/2017 |
| microglia may self-limit their inflammatory response by producing the negative regulator IL-19. | Interleukin-19 acts as a negative autocrine regulator of activated microglia.
Horiuchi H, Parajuli B, Wang Y, Azuma YT, Mizuno T, Takeuchi H, Suzumura A., Free PMC Article | 05/16/2016 |
| Lack of IL-19 exacerbates intimal hyperplasia | IL-19 reduces ligation-mediated neointimal hyperplasia by reducing vascular smooth muscle cell activation.
Ellison S, Gabunia K, Richards JM, Kelemen SE, England RN, Rudic D, Azuma YT, Munroy MA, Eguchi S, Autieri MV., Free PMC Article | 04/4/2015 |
| we delineate the detailed molecular pathway for IL-4 up-regulation of IL-19 in keratinocytes, which may play an important role in AD pathogenesis. | Interleukin-4 up-regulation of epidermal interleukin-19 expression in keratinocytes involves the binding of signal transducer and activator of transcription 6 (Stat6) to the imperfect Stat6 sites.
Bao L, Alexander JB, Shi VY, Mohan GC, Chan LS., Free PMC Article | 01/10/2015 |
| Il-19 expression is increased in astrocytes following bacterial challenge. | Astrocytes produce IL-19 in response to bacterial challenge and are sensitive to the immunosuppressive effects of this IL-10 family member.
Cooley ID, Chauhan VS, Donneyz MA, Marriott I., Free PMC Article | 11/29/2014 |
| IL-19 is important for cutaneous wound healing because it upregulates KGF expression. | Interleukin (IL)-19 promoted skin wound healing by increasing fibroblast keratinocyte growth factor expression.
Sun DP, Yeh CH, So E, Wang LY, Wei TS, Chang MS, Hsing CH. | 02/1/2014 |
| IL-19 is a potent inhibitor of experimental atherosclerosis. | Attenuation of experimental atherosclerosis by interleukin-19.
Ellison S, Gabunia K, Kelemen SE, England RN, Scalia R, Richards JM, Orr AW, Traylor JG Jr, Rogers T, Cornwell W, Berglund LM, Goncalves I, Gomez MF, Autieri MV., Free PMC Article | 11/30/2013 |
| IL-19 is pivotal in the pathogenesis of breast cancer. | Upregulated IL-19 in breast cancer promotes tumor progression and affects clinical outcome.
Hsing CH, Cheng HC, Hsu YH, Chan CH, Yeh CH, Li CF, Chang MS. | 05/26/2012 |
| endogenous IL-19 is a constituent of the regulome that controls both processes in vivo | Interleukin-19: a constituent of the regulome that controls antigen presenting cells in the lungs and airway responses to microbial products.
Hoffman C, Park SH, Daley E, Emson C, Louten J, Sisco M, de Waal Malefyt R, Grunig G., Free PMC Article | 03/31/2012 |
| IL-19 drives pathogenic innate immune responses in the colon. | Interleukin-19 protects mice from innate-mediated colonic inflammation.
Azuma YT, Matsuo Y, Kuwamura M, Yancopoulos GD, Valenzuela DM, Murphy AJ, Nakajima H, Karow M, Takeuchi T. | 08/23/2010 |
| In a dust mite-induced murine model of asthma, the IL-19 level in asthmatic BALB/cJ mice is twice that of healthy control mice. | IL-19 induced Th2 cytokines and was up-regulated in asthma patients.
Liao SC, Cheng YC, Wang YC, Wang CW, Yang SM, Yu CK, Shieh CC, Cheng KC, Lee MF, Chiang SR, Shieh JM, Chang MS. | 01/21/2010 |