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    HRG histidine rich glycoprotein [ Homo sapiens (human) ]

    Gene ID: 3273, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of histidine-rich glycoprotein C633T single nucleotide polymorphism and recurrent miscarriage in Iranian women.

    Association of histidine-rich glycoprotein C633T single nucleotide polymorphism and recurrent miscarriage in Iranian women.
    Latifimehr M, Rastegari AA, Zamani Z, Fard-Esfahani P, Nazari L.

    07/15/2024
    The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women.

    The Association between Histidine-Rich Glycoprotein rs10770 Genotype and Recurrent Miscarriage in Iranian Women.
    Latifimehr M, Nazari L, Rastegari AA, Zamani Z, Fard-Esfahani P., Free PMC Article

    05/8/2024
    [The plasma protein HRG is an important factor for preventing sepsis and maintaining homeostatic response].

    [The plasma protein HRG is an important factor for preventing sepsis and maintaining homeostatic response].
    Nishibori M, Wake H, Sakaguchi M.

    03/5/2024
    Zn[2+] Differentially Influences the Neutralisation of Heparins by HRG, Fibrinogen, and Fibronectin.

    Zn(2+) Differentially Influences the Neutralisation of Heparins by HRG, Fibrinogen, and Fibronectin.
    Sobczak AIS, Ajjan RA, Stewart AJ., Free PMC Article

    12/20/2023
    Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells.

    Histidine-Rich Glycoprotein Suppresses the S100A8/A9-Mediated Organotropic Metastasis of Melanoma Cells.
    Tomonobu N, Kinoshita R, Wake H, Inoue Y, Ruma IMW, Suzawa K, Gohara Y, Komalasari NLGY, Jiang F, Murata H, Yamamoto KI, Sumardika IW, Chen Y, Futami J, Yamauchi A, Kuribayashi F, Kondo E, Toyooka S, Nishibori M, Sakaguchi M., Free PMC Article

    10/8/2022
    Comparison of Histidine rich glycoprotein, a novel biomarker for sepsis, with traditional biomarkers in adult ICU patients.

    Comparison of Histidine rich glycoprotein, a novel biomarker for sepsis, with traditional biomarkers in adult ICU patients.
    Fouad MA, Abd Elrahman AH, El-Melouk MS.

    04/23/2022
    Effects of HRG and TP73 gene variations on ovarian response.

    Effects of HRG and TP73 gene variations on ovarian response.
    Bakay K, Coban U, Arslan MA, Guven D, Tural S.

    04/9/2022
    Histidine-rich glycoprotein as a prognostic biomarker for sepsis.

    Histidine-rich glycoprotein as a prognostic biomarker for sepsis.
    Kuroda K, Ishii K, Mihara Y, Kawanoue N, Wake H, Mori S, Yoshida M, Nishibori M, Morimatsu H., Free PMC Article

    11/13/2021
    Histidine-Rich Glycoprotein Stimulates Human Neutrophil Phagocytosis and Prolongs Survival through CLEC1A.

    Histidine-Rich Glycoprotein Stimulates Human Neutrophil Phagocytosis and Prolongs Survival through CLEC1A.
    Takahashi Y, Wake H, Sakaguchi M, Yoshii Y, Teshigawara K, Wang D, Nishibori M., Free PMC Article

    07/24/2021
    HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma.

    HRG switches TNFR1-mediated cell survival to apoptosis in Hepatocellular Carcinoma.
    Zou X, Zhang D, Song Y, Liu S, Long Q, Yao L, Li W, Duan Z, Wu D, Liu L., Free PMC Article

    06/5/2021
    Histidine-rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF-kappaB and MAPK signal pathway.

    Histidine-rich glycoprotein ameliorates endothelial barrier dysfunction through regulation of NF-κB and MAPK signal pathway.
    Gao S, Wake H, Gao Y, Wang D, Mori S, Liu K, Teshigawara K, Takahashi H, Nishibori M., Free PMC Article

    09/12/2020
    Ultrastructural Localization of Histidine-rich Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP Deaminase.

    Ultrastructural Localization of Histidine-rich Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP Deaminase.
    Mattii L, Bianchi F, Falleni A, Frascarelli S, Masini M, Alì G, Chiellini G, Sabbatini ARM., Free PMC Article

    08/15/2020
    Levels of caspase-3 and histidine-rich glycoprotein in the embryo secretome as biomarkers of good-quality day-2 embryos and high-quality blastocysts

    Levels of caspase-3 and histidine-rich glycoprotein in the embryo secretome as biomarkers of good-quality day-2 embryos and high-quality blastocysts.
    Kaihola H, Yaldir FG, Bohlin T, Samir R, Hreinsson J, Åkerud H., Free PMC Article

    04/4/2020
    The HRG C633T genotype seems to be associated with gestational hypertensive disorders

    HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study.
    Elenis E, Skalkidou A, Skoog-Svanberg A, Sydsjö G, Stavreus-Evers A, Åkerud H., Free PMC Article

    12/22/2018
    A novel heterozygous single base pair substitution in exon 2 of HRG gene identified in a familial early-onset deep venous thrombosis case.

    Familial early-onset deep venous thrombosis associated with a novel HRG mutation.
    Luo J, Zhang W, Zeng Q, Zhou W, Cao Q, Zhou W.

    08/18/2018
    presence of HRG mRNA did not depend on the cancer type, on the preoperative treatment or its absence, as well as on the tumor progression stage and the presence of metastases

    Messenger RNA of the Histidine-Rich Glycoprotein in Breast Tumors.
    Autenshlyus AI, Brusentsov II, Marinkin IO, Smirnova SA, Rukavishnikov MY, Lyakhovich VV.

    04/14/2018
    C633T SNP had no significant effect on sperm DNA integrity

    Relationship of DNA integrity to HRG C633T SNP and ART outcome in infertile couples.
    Kumaresan A, Johannisson A, Nordqvist S, Kårehed K, Åkerud H, Lindgren KE, Morrell JM.

    03/17/2018
    once infertility is established the HRG C633T SNP seems to be important for male infertility and pregnancy rate following IVF

    The effect of a specific histidine-rich glycoprotein polymorphism on male infertility and semen parameters.
    Lindgren KE, Nordqvist S, Kårehed K, Sundström-Poromaa I, Åkerud H.

    08/5/2017
    These data highlight the complex divalent metal-dependent regulatory mechanisms that govern HRG function.

    Divalent metal binding by histidine-rich glycoprotein differentially regulates higher order oligomerisation and proteolytic processing.
    Priebatsch KM, Poon IK, Patel KK, Kvansakul M, Hulett MD.

    05/27/2017
    HRG attenuates DNA- and RNA-mediated FXII activation, and FXI activation by FXIIa or by thrombin, suggesting that HRG down regulates the capacity of DNA and RNA to activate the intrinsic coagulation pathway.

    Histidine-rich glycoprotein binds DNA and RNA and attenuates their capacity to activate the intrinsic coagulation pathway.
    Vu TT, Leslie BA, Stafford AR, Zhou J, Fredenburgh JC, Weitz JI.

    10/1/2016
    HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

    Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with α2 integrin.
    Roche F, Sipilä K, Honjo S, Johansson S, Tugues S, Heino J, Claesson-Welsh L.

    09/10/2016
    HRG could inhibit hepatocellular carcinoma cell proliferation via the FGF-Erk1/2 signaling pathway by reducing Erk1/2 phosphorylation.

    Histidine-rich glycoprotein function in hepatocellular carcinoma depends on its N-glycosylation status, and it regulates cell proliferation by inhibiting Erk1/2 phosphorylation.
    Zhang Q, Jiang K, Li Y, Gao D, Sun L, Zhang S, Liu T, Guo K, Liu Y., Free PMC Article

    08/6/2016
    Plasma free fatty acid levels influence Zn(2+) -dependent histidine-rich glycoprotein-heparin interactions via an allosteric switch on serum albumin.

    Plasma free fatty acid levels influence Zn(2+) -dependent histidine-rich glycoprotein-heparin interactions via an allosteric switch on serum albumin.
    Kassaar O, Schwarz-Linek U, Blindauer CA, Stewart AJ., Free PMC Article

    03/5/2016
    mononuclear phagocytes have specific binding sites for HRG and that these cells are essential for uptake of HRG from blood and distribution of HRG in tissues. Thus, inflammatory cells mediate the effect of HRG on tumor growth and metastatic spread.

    Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes.
    Tugues S, Roche F, Noguer O, Orlova A, Bhoi S, Padhan N, Akerud P, Honjo S, Selvaraju RK, Mazzone M, Tolmachev V, Claesson-Welsh L., Free PMC Article

    06/20/2015
    Results show that HRG is a novel transcriptional target gene of FXR in human hepatoma cells, human upcyteVR primary hepatocytes and 3D human liver microtissues in vitro and in mouse liver in vivo.

    The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein.
    Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perović-Ottstadt S, Schulz A, Hahn U, Burnet M, Kremoser C.

    06/6/2015
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