| The ZAR1 protein in cancer; from epigenetic silencing to functional characterisation and epigenetic therapy of tumour suppressors. | The ZAR1 protein in cancer; from epigenetic silencing to functional characterisation and epigenetic therapy of tumour suppressors.
Deutschmeyer VE, Richter AM. | 01/23/2021 |
| Variation Screening of Zygote Arrest 1(ZAR1) in Women with Recurrent Zygote Arrest During IVF/ICSI Programs. | Variation Screening of Zygote Arrest 1(ZAR1) in Women with Recurrent Zygote Arrest During IVF/ICSI Programs.
Tian Y, Yang J, Peng Y, Chen T, Huang T, Zhang C, Zhao H. | 12/19/2020 |
| Study presents evidence that ZAR1, which harbors tumor suppressive properties, is a prognostic and diagnostic cancer biomarker for lung and kidney. ZAR1 suppresses tumor cell line growth in part through p53 and strongly depending on its functional zinc-finger. | Epigenetic therapy of novel tumour suppressor ZAR1 and its cancer biomarker function.
Deutschmeyer V, Breuer J, Walesch SK, Sokol AM, Graumann J, Bartkuhn M, Boettger T, Rossbach O, Richter AM., Free PMC Article | 07/25/2020 |
| ZAR1 has oncogenic effects in neuroblastoma by suppressing cell differentiation via regulation of MYCN expression.Elevated ZAR1 expression level is closely related to poor prognosis of patients with neuroblastoma. | ZAR1 knockdown promotes the differentiation of human neuroblastoma cells by suppression of MYCN expression.
Watanabe Y, Ishizuka Y, Hirano T, Nagasaki-Maeoka E, Hoshi R, Yoshizawa S, Uekusa S, Kawashima H, Sugito K, Shinohara K, Fukuda N, Nagase H, Soma M, Koshinaga T, Fujiwara K. | 05/19/2018 |
| Study shows for the first time the lung tumor-specific epigenetic inactivation of ZAR1 due to DNA methylation of its CpG island promoter. Furthermore, ZAR1 was characterized by the ability to block tumor growth through the inhibition of cell cycle progression in cancer cell lines. | ZAR1 is a novel epigenetically inactivated tumour suppressor in lung cancer.
Richter AM, Kiehl S, Köger N, Breuer J, Stiewe T, Dammann RH., Free PMC Article | 04/21/2018 |
| A decreased methylation level at CpG sites of ZAR1 exon 1/intron 1. CpGi could serve as a biomarker for invasive bladder cancer. | Identification of frequent differentially methylated region in sporadic bladder cancers.
Hasegawa R, Fujiwara K, Obinata D, Kawashima H, Shinojima Y, Igarashi J, Wang X, Ghosh S, Nagase H, Takahashi S. | 03/5/2016 |
| ZAR1 and SFRP4 qMSP could be used as potential biomarker for CC diagnosis | Evaluation of ZAR1 and SFRP4 methylation status as potentials biomarkers for diagnosis in cervical cancer: exploratory study phase I.
Brebi P, Hoffstetter R, Andana A, Ili CG, Saavedra K, Viscarra T, Retamal J, Sanchez R, Roa JC. | 01/3/2015 |
| Hypermethylation of ZAR1 regions is extremely frequent in neuroblastomas and correlates with established markers of progressive disease and outcome. | Non-promoter DNA hypermethylation of Zygote Arrest 1 (ZAR1) in neuroblastomas.
Sugito K, Kawashima H, Yoshizawa S, Uekusa S, Hoshi R, Furuya T, Kaneda H, Hosoda T, Konuma N, Masuko T, Ohashi K, Ikeda T, Koshinaga T, Tomita R, Shinojima Y, Fujiwara K, Watanabe T, Held WA, Nagase H. | 11/16/2013 |
| Findings indicate that non-promoter hypermethylation of ZAR1 is extremely frequent in diffuse gliomas and pituitary adenomas, but methylation-related aberrant ZAR1 expression is far less likely to be related to glioma tumorigenesis. | Aberrant hypermethylation of non-promoter zygote arrest 1 (ZAR1) in human brain tumors.
Watanabe T, Yachi K, Ohta T, Fukushima T, Yoshino A, Katayama Y, Shinojima Y, Terui T, Nagase H. | 05/7/2011 |
| we identified a frequently aberrant methylated region within the Zygote arrest 1 (ZAR1) gene in melanoma and demonstrated a distinct methylation pattern between melanoma and nevus.The involvement of ZAR1 in the carcinogenesis of melanoma remains unclear. | Identification and analysis of an early diagnostic marker for malignant melanoma: ZAR1 intra-genic differential methylation.
Shinojima Y, Terui T, Hara H, Kimura M, Igarashi J, Wang X, Kawashima H, Kobayashi Y, Muroi S, Hayakawa S, Esumi M, Fujiwara K, Ghosh S, Yamamoto T, Held W, Nagase H., Free PMC Article | 11/27/2010 |
| The carboxyl-termini of these ZAR1 proteins contain an important functional domain that is conserved through vertebrate evolution and that may be necessary for normal female reproduction in the transition from oocyte to embryonic life. | Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries.
Wu X, Wang P, Brown CA, Zilinski CA, Matzuk MM. | 01/21/2010 |
| Zygote arrest 1 (ZAR1) could be implicated in regulation of meiosis and post meiotic differentiation of male and female germ cells through expression of shorter splicing variants. Central role of this gene in early reproductive processes. | Zygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells.
Uzbekova S, Roy-Sabau M, Dalbiès-Tran R, Perreau C, Papillier P, Mompart F, Thelie A, Pennetier S, Cognie J, Cadoret V, Royere D, Monget P, Mermillod P., Free PMC Article | 01/21/2010 |