| Haptoglobin-Related Protein without Signal Peptide as Biomarker of Renal Salt Wasting in Hyponatremia, Hyponatremia-Related Diseases and as New Syndrome in Alzheimer's Disease. | Haptoglobin-Related Protein without Signal Peptide as Biomarker of Renal Salt Wasting in Hyponatremia, Hyponatremia-Related Diseases and as New Syndrome in Alzheimer's Disease.
Maesaka JK, Imbriano LJ, Grant C, Miyawaki N., Free PMC Article | 05/22/2023 |
| Haptoglobin-related protein in human plasma correlates to haptoglobin concentrations and phenotypes. | Haptoglobin-related protein in human plasma correlates to haptoglobin concentrations and phenotypes.
Skytthe MK, Sørensen AL, Hennig D, Sandberg MB, Rasmussen LM, Højrup P, Møller HJ, Skjødt K, Moestrup SK, Graversen JH. | 10/8/2022 |
| Haptoglobin polymorphisms in Latin American populations. | Haptoglobin polymorphisms in Latin American populations.
Soejima M, Koda Y., Free PMC Article | 12/19/2020 |
| These results indicate that HPR is a potential serologic biomarker which can differentiate between bacterial pneumonia and nonbacterial pneumonia. Detection of serum HPR might be useful for clinical diagnosis. | Lectin Microarray Combined with Mass Spectrometry Identifies Haptoglobin-Related Protein (HPR) as a Potential Serologic Biomarker for Separating Nonbacterial Pneumonia from Bacterial Pneumonia in Childhood.
Yang L, Yang Z, Cheng L, Cheng J, Cheng L, Sun Y, Li W, Song K, Huang W, Yin Y, Tao S, Zhang Q. | 04/13/2019 |
| the haptoglobin (HP) rs8062041 appeared to be protective against African Trypanosomiasis; HPR is adjacent to HP and is a component of the Trypanolytic factor; the HP and HPR locus is duplicated in some people; the rs8062041 variant may be associated with this duplication and it is possible that increased production of HPR is the cause of protection associated with rs806204 | A polymorphism in the haptoglobin, haptoglobin related protein locus is associated with risk of human sleeping sickness within Cameroonian populations.
Ofon E, Noyes H, Mulindwa J, Ilboudo H, Simuunza M, Ebo'o V, Njiokou F, Koffi M, Bucheton B, Fogue P, Hertz-Fowler C, MacLeod A, Simo G, TrypanoGEN Research Group, as members of The H3Africa Consortium., Free PMC Article | 12/2/2017 |
| Data indicate that haptoglobin-related protein (Hpr) is presented at the surface of hepG2 cells. | A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein.
Harrington JM, Nishanova T, Pena SR, Hess M, Scelsi CL, Widener J, Hajduk SL., Free PMC Article | 01/31/2015 |
| Our analysis illustrates the complex interplay between functions and haplotypes of adjacent genes, environmental context and natural selection, and offers insights into potential use of haptoglobin or haptoglobin-related protein as therapeutic agents. | Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol.
Guthrie PA, Rodriguez S, Gaunt TR, Lawlor DA, Smith GD, Day IN., Free PMC Article | 06/23/2012 |
| show that trypanosome lytic factor-1 resistance in Trypanosoma brucei brucei is caused by reduced expression of the Hp/Hb receptor gene. | Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor.
Kieft R, Capewell P, Turner CM, Veitch NJ, MacLeod A, Hajduk S., Free PMC Article | 02/3/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesInvestigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. | 09/15/2010 |
| at low pH. Trypanosome lytic factor, apoL-1, and apoA-1 exhibit specificity for anionic membranes, whereas Hpr permeabilizes both anionic and zwitterionic membranes. | Membrane permeabilization by trypanosome lytic factor, a cytolytic human high density lipoprotein.
Harrington JM, Howell S, Hajduk SL., Free PMC Article | 01/21/2010 |
| Infection by Trypanosoma brucei brucei causes hemolysis that triggers activation of trypanosome lytic factor by formation of haptoglobin-related protein-hemoglobin complexes, enhancing binding, trypanolytic activity, and clearance of parasites. | Hemoglobin is a co-factor of human trypanosome lytic factor.
Widener J, Nielsen MJ, Shiflett A, Moestrup SK, Hajduk S., Free PMC Article | 01/21/2010 |
| recombinant Hpr binds hemoglobin as efficiently as haptoglobin | Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein.
Nielsen MJ, Petersen SV, Jacobsen C, Oxvig C, Rees D, Møller HJ, Moestrup SK. | 01/21/2010 |
| apoL-I is responsible for the trypanolytic activity of normal human serum, whereas Hpr allows fast uptake of the carrier HDL particles in trypanolysis | Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum.
Vanhollebeke B, Nielsen MJ, Watanabe Y, Truc P, Vanhamme L, Nakajima K, Moestrup SK, Pays E., Free PMC Article | 01/21/2010 |
| No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein | No trypanosome lytic activity in the sera of mice producing human haptoglobin-related protein.
Hatada S, Seed JR, Barker C, Hajduk SL, Black S, Maeda N. | 01/21/2010 |