| HOXC9 characterizes a suppressive tumor immune microenvironment and integration with multiple immune biomarkers predicts response to PD-1 blockade plus chemotherapy in lung adenocarcinoma. | HOXC9 characterizes a suppressive tumor immune microenvironment and integration with multiple immune biomarkers predicts response to PD-1 blockade plus chemotherapy in lung adenocarcinoma.
Liu L, Zhang Z, Jiang C, Zhu Y, Han R, Wu L, Xu Y., Free PMC Article | 03/22/2024 |
| circRNA-mediated upregulation of HOXC9 is correlated with poor outcome and immune microenvironment infiltrates in LUAD. | circRNA-mediated upregulation of HOXC9 is correlated with poor outcome and immune microenvironment infiltrates in LUAD.
Liu Y, Jing L, Zhang J. | 11/19/2022 |
| Upregulation of HOXC9 generates interferon-gamma resistance in gastric cancer by inhibiting the DAPK1/RIG1/STAT1 axis. | Upregulation of HOXC9 generates interferon-gamma resistance in gastric cancer by inhibiting the DAPK1/RIG1/STAT1 axis.
Tang Y, Wang T, Yu Y, Yan Y, Wu C., Free PMC Article | 09/18/2021 |
| HOXC9 overexpression is associated with gastric cancer progression and a prognostic marker for poor survival in gastric cancer patients. | HOXC9 overexpression is associated with gastric cancer progression and a prognostic marker for poor survival in gastric cancer patients.
Zhao XF, Yang YS, Park YK. | 01/16/2021 |
| Transcription factor homeobox C9 (HOXC9) may play a critical role in colorectal cancer (CRC) progression and serve as a potential marker of poor prognosis in CRC. | Clinical Prognostic Significance of HOXC9 Expression in Patients with Colorectal Cancer.
Hu M, Ou-Yang W, Jing D, Chen R. | 01/25/2020 |
| HOXC9 knockdown inhibited the metastasis and stem cell-like phenotype of GC cells without significant effects on cell proliferation as a direct target of miR-26a. | miR-26a/HOXC9 Dysregulation Promotes Metastasis and Stem Cell-Like Phenotype of Gastric Cancer.
Peng X, Kang Q, Wan R, Wang Z. | 10/20/2018 |
| downregulation of HOXC9 releases its transcriptional inhibition of DAPK1, resulting in the activation of the DAPK1-Beclin1 pathway, which induces autophagy in glioblastoma cells | Homeobox C9 suppresses Beclin1-mediated autophagy in glioblastoma by directly inhibiting the transcription of death-associated protein kinase 1.
Xuan F, Huang M, Liu W, Ding H, Yang L, Cui H., Free PMC Article | 10/14/2017 |
| HOXC9 and HOXC10 may play an important role in the development of obesity, adverse fat distribution, and subsequent alterations in whole-body metabolism and adipose tissue function. | Fat depot-specific expression of HOXC9 and HOXC10 may contribute to adverse fat distribution and related metabolic traits.
Brune JE, Kern M, Kunath A, Flehmig G, Schön MR, Lohmann T, Dressler M, Dietrich A, Fasshauer M, Kovacs P, Stumvoll M, Blüher M, Klöting N. | 07/30/2016 |
| Results provide a set of the essential genes in the miR-193a-3p/HOXC9/DNA damage response/oxidative stress pathway axis as the diagnostic targets for the guided anti-bladder cancer chemotherapy. | MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene.
Lv L, Li Y, Deng H, Zhang C, Pu Y, Qian L, Xiao J, Zhao W, Liu Q, Zhang D, Wang Y, Zhang H, He Y, Zhu J. | 04/25/2015 |
| HOXC9 coordinates diverse cellular processes associated with differentiation by directly activating and repressing the transcription of distinct sets of genes. | HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation.
Wang X, Choi JH, Ding J, Yang L, Ngoka LC, Lee EJ, Zha Y, Mao L, Jin B, Ren M, Cowell J, Huang S, Shi H, Cui H, Ding HF., Free PMC Article | 07/5/2014 |
| HoxC9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma. | Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma.
Kocak H, Ackermann S, Hero B, Kahlert Y, Oberthuer A, Juraeva D, Roels F, Theissen J, Westermann F, Deubzer H, Ehemann V, Brors B, Odenthal M, Berthold F, Fischer M., Free PMC Article | 08/31/2013 |
| We did not find any potential pathological mutations in the Hoxc9 gene among Chinese patients with congenital heart disease. | Homeobox C9 is not potentially related to congenital heart disease in Chinese patients.
Sun L, Cheng L, Li C, Gao B, Wang B, Wang J, Wang X, Huang T, Li H, Ma X., Free PMC Article | 10/13/2012 |
| HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma. | HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma.
Mao L, Ding J, Zha Y, Yang L, McCarthy BA, King W, Cui H, Ding HF., Free PMC Article | 08/20/2011 |
| The data identify HOXC9 as an endothelial cell active transcriptional repressor promoting the resting, antiangiogenic endothelial cell phenotype in an interleukin 8-dependent manner | The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8.
Stoll SJ, Bartsch S, Augustin HG, Kroll J. | 08/20/2011 |
| Methylated state of this set of genes may be more specific to the late rather than the early stage of NSCLC. | RASSF1A, APC, ESR1, ABCB1 and HOXC9, but not p16INK4A, DAPK1, PTEN and MT1G genes were frequently methylated in the stage I non-small cell lung cancer in China.
Lin Q, Geng J, Ma K, Yu J, Sun J, Shen Z, Bao G, Chen Y, Zhang H, He Y, Luo X, Feng X, Zhu J. | 01/21/2010 |
| Up-regulation of HOXC9 was detected in a set of 54 astrocytomas of different grades and significantly associated with malignancy. | Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes.
Okamoto OK, Oba-Shinjo SM, Lopes L, Nagahashi Marie SK. | 01/21/2010 |