| HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis. | HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis.
Zhang H, Han B, Tian S, Gong Y, Chen L, Liu L., Free PMC Article | 08/30/2024 |
| A likely HOXC4 predisposition variant for Chiari malformations. | A likely HOXC4 predisposition variant for Chiari malformations.
Brockmeyer DL, Cheshier SH, Stevens J, Facelli JC, Rowe K, Heiss JD, Musolf A, Viskochil DH, Allen-Brady KL, Cannon-Albright LA., Free PMC Article | 07/12/2023 |
| Homeobox C4 promotes hepatocellular carcinoma progression by the transactivation of Snail. | Homeobox C4 promotes hepatocellular carcinoma progression by the transactivation of Snail.
Yang T, Zhang XB, Li XN, Sun MZ, Gao PZ. | 02/13/2021 |
| he upregulation of miR-608 reduced the expression of HOXC4 in the uveal melanoma cells, which was rescued by overexpression of MALAT1. Hence, MALAT1 could upregulate the HOXC4 by binding to miR-608. | Suppression of long noncoding RNA MALAT1 inhibits the development of uveal melanoma via microRNA-608-mediated inhibition of HOXC4.
Wu S, Chen H, Zuo L, Jiang H, Yan H., Free PMC Article | 08/12/2020 |
| HOXC4 homeoprotein expands human hematopoietic immature cells by 3 to 6 times ex vivo and significantly improves the level of in vivo engraftment. | HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.
Auvray C, Delahaye A, Pflumio F, Haddad R, Amsellem S, Miri-Nezhad A, Broix L, Yacia A, Bulle F, Fichelson S, Vigon I., Free PMC Article | 09/22/2012 |
| Human cytomegalovirus downregulates while all-trans retinoic acid upregulates expression of hoxc4 and hoxc6 in lymphocytic progenitor cells. | [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells].
Feng JQ, Liu WJ, Chen HY, Guo QL, Chen A, Chen SQ. | 08/27/2011 |
| Esr1 bind to and activate the HOXC4 promoter to potentiate HoxC4-mediated AID induction, immunoglobulin class switch and somatic hypermutation. | Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation.
Mai T, Zan H, Zhang J, Hawkins JS, Xu Z, Casali P., Free PMC Article | 01/1/2011 |
| HoxC4 directly activates the Aicda promoter | HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation.
Park SR, Zan H, Pal Z, Zhang J, Al-Qahtani A, Pone EJ, Xu Z, Mai T, Casali P., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease.
Gong LG, Qiu GR, Jiang H, Xu XY, Zhu HY, Sun KL. | 03/13/2008 |
| Selective inhibition of class switching to IgG and IgE by recruitment of this and Oct-1 proteins and Ku70/Ku86 to newly identified ATTT cis-elements. | Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements.
Schaffer A, Kim EC, Wu X, Zan H, Testoni L, Salamon S, Cerutti A, Casali P. | 01/21/2010 |
| The hs1,2mediated enhancement of V(H) and C(H) promoter-driven transcription as induced by HoxC4 and Oct-1/Oct-2 suggests an important role of these homeodomain proteins in the overall regulation of the IgH locus expression. | The HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombination.
Kim EC, Edmonston CR, Wu X, Schaffer A, Casali P., Free PMC Article | 01/21/2010 |
| The HOXC4 expression was clearly detected in all inv(7) positive patients. | A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias.
Speleman F, Cauwelier B, Dastugue N, Cools J, Verhasselt B, Poppe B, Van Roy N, Vandesompele J, Graux C, Uyttebroeck A, Boogaerts M, De Moerloose B, Benoit Y, Selleslag D, Billiet J, Robert A, Huguet F, Vandenberghe P, De Paepe A, Marynen P, Hagemeijer A. | 01/21/2010 |