| Integrin beta8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-beta1/TGFBR1/Smad3 pathway in diabetic kidney disease. | Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
Cao Y, Su H, Zeng J, Xie Y, Liu Z, Liu F, Qiu Y, Yi F, Lin J, Hammes HP, Zhang C. | 02/16/2024 |
| The beta8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development. | The β8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development.
De A, Morales JE, Chen Z, Sebastian S, McCarty JH., Free PMC Article | 04/16/2022 |
| Integrin alphavbeta8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy. | Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D., Free PMC Article | 02/12/2022 |
| Regulatory T cells promote cancer immune-escape through integrin alphavbeta8-mediated TGF-beta activation. | Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation.
Lainé A, Labiad O, Hernandez-Vargas H, This S, Sanlaville A, Léon S, Dalle S, Sheppard D, Travis MA, Paidassi H, Marie JC., Free PMC Article | 01/1/2022 |
| miR222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8. | miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8.
Bai YY, Niu JZ., Free PMC Article | 10/10/2020 |
| These data identify novel roles for alphaVbeta8 and TGFbeta signaling in coordinating microgliogenesis with brain development and implicate abnormally programmed microglia or their products in human neurodevelopmental disorders that share this neuropathology. | Impaired αVβ8 and TGFβ signaling lead to microglial dysmaturation and neuromotor dysfunction.
Arnold TD, Lizama CO, Cautivo KM, Santander N, Lin L, Qiu H, Huang EJ, Liu C, Mukouyama YS, Reichardt LF, Zovein AC, Sheppard D., Free PMC Article | 05/9/2020 |
| These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF. Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice. | Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.
Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H., Free PMC Article | 09/30/2017 |
| data show that the combination of cell lineage, immune mediators and both dietary and microbe-derived environmental factors shape intestinal dendritic cells into critical gatekeepers of TGF-beta-dependent immune responses through regulation of beta8 integrin expression | β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage.
Boucard-Jourdin M, Kugler D, Endale Ahanda ML, This S, De Calisto J, Zhang A, Mora JR, Stuart LM, Savill J, Lacy-Hulbert A, Paidassi H., Free PMC Article | 08/26/2017 |
| Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta. | Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH., Free PMC Article | 08/13/2016 |
| Nrp1 in endothelial cells suppresses TGFbeta activation and signaling by forming intercellular protein complexes with beta8 integrin. | Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain.
Hirota S, Clements TP, Tang LK, Morales JE, Lee HS, Oh SP, Rivera GM, Wagner DS, McCarty JH., Free PMC Article | 05/28/2016 |
| ITGB8 is involved in the embryo implantation process through regulation of activation of TGFB1 | Integrin beta 8 (ITGB8) regulates embryo implantation potentially via controlling the activity of TGF-B1 in mice.
Kumar V, Maurya VK, Joshi A, Meeran SM, Jha RK. | 12/26/2015 |
| Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1. | Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.
Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, Paidassi H, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH., Free PMC Article | 06/6/2015 |
| integrin alphavbeta8 is a marker of T regulatory cells and functions in a cell intrinsic manner in mediating the processing of latent TGF-beta1 from the latent TGF-beta1/GARP complex on the surface of Activated T regulatory cells. | Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8.
Edwards JP, Thornton AM, Shevach EM., Free PMC Article | 11/29/2014 |
| Mesangial cell alphavbeta8-integrin regulates glomerular capillary integrity and repair. | Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair.
Lakhe-Reddy S, Li V, Arnold TD, Khan S, Schelling JR., Free PMC Article | 10/4/2014 |
| alphavbeta8 integrin, via interactions with RhoGDI1, regulates activation of Rho proteins to promote glioblastoma multiforme cell invasiveness. | αvβ8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion.
Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH., Free PMC Article | 07/27/2013 |
| these data identify essential cell-intrinsic functions for beta8 integrin in regulating neuroblast polarity and directional navigation in the mouse forebrain | β8 integrin is essential for neuroblast migration in the rostral migratory stream.
Mobley AK, McCarty JH. | 01/7/2012 |
| The astrocyte-expressed integrin alphavbeta8 governs blood vessel sprouting in the developing retina. | The astrocyte-expressed integrin αvβ8 governs blood vessel sprouting in the developing retina.
Hirota S, Liu Q, Lee HS, Hossain MG, Lacy-Hulbert A, McCarty JH., Free PMC Article | 01/7/2012 |
| Data suggest that lung fibroblast chemokine secretion directs dendritic cell trafficking, in a manner that is critically dependent on alphavbeta8-mediated activation of TGF-beta by fibroblasts. | Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.
Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL., Free PMC Article | 10/15/2011 |
| Under pathological conditions associated with decreased mesangial cell alphavbeta8 expression and TGF-beta secretion, compensatory PECAM-1 modulation facilitates glomerular endothelial cell survival. | Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1.
Khan S, Lakhe-Reddy S, McCarty JH, Sorenson CM, Sheibani N, Reichardt LF, Kim JH, Wang B, Sedor JR, Schelling JR., Free PMC Article | 05/28/2011 |
| Cell adhesion and signaling pathways regulated by alphavbeta8 integrin and Band 4.1B are essential for normal formation and function of the heart during embryogenesis. | β8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart.
Jung Y, Kissil JL, McCarty JH. | 05/14/2011 |
| Th17 cells were nearly absent in the colons of mice lacking alphavbeta8 expression on dendritic cells (DCs). In addition, these mice and the DCs harvested from them had an impaired ability to convert naive T cells into Th17 cells. | Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice.
Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D., Free PMC Article | 01/15/2011 |
| Alphavbeta8 integrin is a negative regulator of tumor angiogenesis. | A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis.
Tchaicha JH, Mobley AK, Hossain MG, Aldape KD, McCarty JH., Free PMC Article | 09/13/2010 |
| Results identify essential functions for beta8 integrin in regulating neurovascular unit physiology in the post-natal mouse brain. | Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain.
Mobley AK, Tchaicha JH, Shin J, Hossain MG, McCarty JH., Free PMC Article | 01/21/2010 |
| These results support a model in which TGFbeta3-mediated palate fusion and TGFbeta1-mediated suppression of autoimmunity and generation of Langerhans cells require integrins alphavbeta6 and alphavbeta8 but not other RGD-binding integrins. | Mice that lack activity of alphavbeta6- and alphavbeta8-integrins reproduce the abnormalities of Tgfb1- and Tgfb3-null mice.
Aluwihare P, Mu Z, Zhao Z, Yu D, Weinreb PH, Horan GS, Violette SM, Munger JS., Free PMC Article | 01/21/2010 |
| alpha(v)beta8-mediated TGF-beta activation by dendritic cells is essential for preventing immune dysfunction that results in inflammatory bowel disease and autoimmunity | Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice.
Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D., Free PMC Article | 01/21/2010 |