| Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion. | Protein kinase N promotes cardiac fibrosis in heart failure by fibroblast-to-myofibroblast conversion.
Yoshida S, Yoshida T, Inukai K, Kato K, Yura Y, Hattori T, Enomoto A, Ohashi K, Okumura T, Ouchi N, Kawase H, Wettschureck N, Offermanns S, Murohara T, Takefuji M., Free PMC Article | 09/13/2024 |
| PKN1 Exerts Neurodegenerative Effects in an In Vitro Model of Cerebellar Hypoxic-Ischemic Encephalopathy via Inhibition of AKT/GSK3beta Signaling. | PKN1 Exerts Neurodegenerative Effects in an In Vitro Model of Cerebellar Hypoxic-Ischemic Encephalopathy via Inhibition of AKT/GSK3β Signaling.
Zur Nedden S, Safari MS, Fresser F, Faserl K, Lindner H, Sarg B, Baier G, Baier-Bitterlich G., Free PMC Article | 11/28/2023 |
| Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration. | Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Wang D, Shang Q, Mao J, Gao C, Wang J, Wang D, Wang H, Jia H, Peng P, Du M, Luo Z, Yang L., Free PMC Article | 08/3/2023 |
| PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. | PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation.
Yasuda H, Yamamoto H, Hanamura K, Mehruba M, Kawamata T, Morisaki H, Miyamoto M, Takada S, Shirao T, Ono Y, Mukai H., Free PMC Article | 06/26/2021 |
| Novel roles of PRK1 and PRK2 in cilia and cancer biology. | Novel roles of PRK1 and PRK2 in cilia and cancer biology.
Patel H, Li J, Herrero A, Kroboth J, Byron A, Kriegsheim AV, Brunton V, Carragher N, Hurd T, Frame M., Free PMC Article | 11/28/2020 |
| PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes. | PKN1 kinase-negative knock-in mice develop splenomegaly and leukopenia at advanced age without obvious autoimmune-like phenotypes.
Siddique SM, Kubouchi K, Shinmichi Y, Sawada N, Sugiura R, Itoh Y, Uehara S, Nishimura K, Okamura S, Ohsaki H, Kamoshida S, Yamashita Y, Tamura S, Sonoki T, Matsuoka H, Itoh T, Mukai H., Free PMC Article | 11/21/2020 |
| PKN1 controls the aggregation, spheroid formation, and viability of mouse embryonic fibroblasts in suspension culture. | PKN1 controls the aggregation, spheroid formation, and viability of mouse embryonic fibroblasts in suspension culture.
Mehruba M, Siddique SM, Mukai H. | 09/5/2020 |
| PKN1 and PKN2 activation causes cardiac dysfunction and is involved in the transition to heart failure by phosphorylating MRTFA and disrupting its interaction with actin. | Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin.
Sakaguchi T, Takefuji M, Wettschureck N, Hamaguchi T, Amano M, Kato K, Tsuda T, Eguchi S, Ishihama S, Mori Y, Yura Y, Yoshida T, Unno K, Okumura T, Ishii H, Shimizu Y, Bando YK, Ohashi K, Ouchi N, Enomoto A, Offermanns S, Kaibuchi K, Murohara T. | 07/4/2020 |
| these findings strongly suggest that Msx1 cooperates with Pkn1 to down-regulate Myf5 and, therefore, prevent the differentiation of myogenic precursor cells. | The homeoprotein Msx1 cooperates with Pkn1 to prevent terminal differentiation in myogenic precursor cells.
Zhu X, Li M, Jia X, Hou W, Yang J, Zhao H, Wang G, Wang J. | 12/14/2019 |
| results demonstrate that PKN1 functions as a developmentally active gatekeeper of AKT activity, thereby fine-tuning axonal outgrowth and presynaptic differentiation of Cgcs and subsequently the correct PF-PC synapse formation. | Protein kinase N1 critically regulates cerebellar development and long-term function.
zur Nedden S, Eith R, Schwarzer C, Zanetti L, Seitter H, Fresser F, Koschak A, Cameron AJ, Parker PJ, Baier G, Baier-Bitterlich G., Free PMC Article | 09/14/2019 |
| Cardioprotection by PKN1 is associated with reduced CamKIIdelta-dependent phospholamban Thr17 phosphorylation at the SR and therefore may stabilize the coupling of SR Ca2+ handling and contractile function, independent of its kinase activity. | Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury.
Francois AA, Obasanjo-Blackshire K, Clark JE, Boguslavskyi A, Holt MR, Parker PJ, Marber MS, Heads RJ., Free PMC Article | 05/25/2019 |
| These results reveal a novel role of PKN1 in lymphocyte migration and localization. | Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1.
Mashud R, Nomachi A, Hayakawa A, Kubouchi K, Danno S, Hirata T, Matsuo K, Nakayama T, Satoh R, Sugiura R, Abe M, Sakimura K, Wakana S, Ohsaki H, Kamoshida S, Mukai H., Free PMC Article | 03/2/2019 |
| In mice, phosphorylation-regulated neutrophil polarization mechanism is driven by PKN1-mediated phosphorylation of a newly identified RAB21 effector RPH3A. | PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury.
Yuan Q, Ren C, Xu W, Petri B, Zhang J, Zhang Y, Kubes P, Wu D, Tang W., Free PMC Article | 03/31/2018 |
| Pkn1 is not required for tumorigenesis initiated by loss of Pten. Triple knockout of Pten, Pkn1, and Pkn2 in mouse prostate results in squamous cell carcinoma, an uncommon but therapy-resistant form of prostate cancer. | The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.
Yang CS, Melhuish TA, Spencer A, Ni L, Hao Y, Jividen K, Harris TE, Snow C, Frierson HF Jr, Wotton D, Paschal BM., Free PMC Article | 11/11/2017 |
| Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 and PRK2 to negatively regulate pyrin by phosphorylation. | The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.
Chung LK, Park YH, Zheng Y, Brodsky IE, Hearing P, Kastner DL, Chae JJ, Bliska JB., Free PMC Article | 08/26/2017 |
| Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation | Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.
Yasui T, Sakakibara-Yada K, Nishimura T, Morita K, Tada S, Mosialos G, Kieff E, Kikutani H., Free PMC Article | 03/2/2013 |
| PKN is activated by ischemia/reperfusion and inhibits apoptosis of cardiac myocytes, thereby protecting the heart from I/R injury. | Activation of PKN mediates survival of cardiac myocytes in the heart during ischemia/reperfusion.
Takagi H, Hsu CP, Kajimoto K, Shao D, Yang Y, Maejima Y, Zhai P, Yehia G, Yamada C, Zablocki D, Sadoshima J., Free PMC Article | 10/4/2010 |
| Leishmania mexicana infectivity is associated with differential expression of protein kinase C-like triggered during a cell-cell contact | Infectivity of Leishmania mexicana is associated with differential expression of protein kinase C-like triggered during a cell-cell contact.
Alvarez-Rueda N, Biron M, Le Pape P., Free PMC Article | 03/15/2010 |
| Pkn1 is involved in ganglioside signals that regulate TNF-alpha signaling and synthesis. | Ganglioside GD1a suppresses TNFalpha expression via Pkn1 at the transcriptional level in mouse osteosarcoma-derived FBJ cells.
Wang L, Wang Y, Sato T, Yamagata S, Yamagata T. | 01/21/2010 |