| Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice. | Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice.
Witucki Ł, Jakubowski H. | 10/3/2024 |
| Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine beta-synthase-deficient mice. | Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine β-synthase-deficient mice.
Witucki Ł, Jakubowski H. | 11/16/2023 |
| Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons. | Loss of PHF8 induces a viral mimicry response by activating endogenous retrotransposons.
Liu Y, Hu L, Wu Z, Yuan K, Hong G, Lian Z, Feng J, Li N, Li D, Wong J, Chen J, Liu M, He J, Pang X., Free PMC Article | 09/9/2023 |
| Functional Characterization of a Phf8 Processed Pseudogene in the Mouse Genome. | Functional Characterization of a Phf8 Processed Pseudogene in the Mouse Genome.
St-Germain J, Khan MR, Bavykina V, Desmarais R, Scott M, Boissonneault G, Brunet MA, Laurent B., Free PMC Article | 02/14/2023 |
| The role of PHF8 and TLR4 in osteogenic differentiation of periodontal ligament cells in inflammatory environment. | The role of PHF8 and TLR4 in osteogenic differentiation of periodontal ligament cells in inflammatory environment.
Liu Z, He Y, Xu C, Li J, Zeng S, Yang X, Han Q. | 09/18/2021 |
| The histone demethylase PHF8 regulates astrocyte differentiation and function. | The histone demethylase PHF8 regulates astrocyte differentiation and function.
Iacobucci S, Padilla N, Gabrielli M, Navarro C, Lombardi M, Vicioso-Mantis M, Verderio C, de la Cruz X, Martínez-Balbás MA. | 08/7/2021 |
| Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2. | Histone demethylase PHF8 drives neuroendocrine prostate cancer progression by epigenetically upregulating FOXA2.
Liu Q, Pang J, Wang LA, Huang Z, Xu J, Yang X, Xie Q, Huang Y, Tang T, Tong D, Liu G, Wang L, Zhang D, Ma Q, Xiao H, Lan W, Qin J, Jiang J., Free PMC Article | 06/5/2021 |
| These results clarify the functional role of Phf8 in mammalian development and behavior. | Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.
Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K., Free PMC Article | 11/17/2018 |
| PHD zinc finger 8 protein (Phf8) knockout mice display normal brain development but impaired learning and memory, and compromised long-term potentiation (LTP) in the hippocampus. | Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway.
Chen X, Wang S, Zhou Y, Han Y, Li S, Xu Q, Xu L, Zhu Z, Deng Y, Yu L, Song L, Chen AP, Song J, Takahashi E, He G, He L, Li W, Chen CD., Free PMC Article | 03/3/2018 |
| knockdown of pmaip1 mimicked the phenotype of ph8(-/Y) by showing the decreased apoptosis during early differentiation of embryonic stem cells and promoted mesodermal and cardiac commitment. | Plant Homeo Domain Finger Protein 8 Regulates Mesodermal and Cardiac Differentiation of Embryonic Stem Cells Through Mediating the Histone Demethylation of pmaip1.
Tang Y, Hong YZ, Bai HJ, Wu Q, Chen CD, Lang JY, Boheler KR, Yang HT. | 12/9/2017 |
| PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice. | The histone demethylase PHF8 represses cardiac hypertrophy upon pressure overload.
Liu X, Wang X, Bi Y, Bu P, Zhang M. | 08/29/2015 |
| The gene knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs RA-induced neuronal differentiation. | The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation.
Qiu J, Shi G, Jia Y, Li J, Wu M, Li J, Dong S, Wong J. | 11/6/2010 |
| an important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate | Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate.
Laumonnier F, Holbert S, Ronce N, Faravelli F, Lenzner S, Schwartz CE, Lespinasse J, Van Esch H, Lacombe D, Goizet C, Phan-Dinh Tuy F, van Bokhoven H, Fryns JP, Chelly J, Ropers HH, Moraine C, Hamel BC, Briault S., Free PMC Article | 01/21/2010 |