| CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis. | CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis.
Li J, Han J, Zhao A, Zhang G. | 04/23/2022 |
| MiR-193a-5p suppresses cell proliferation and induces cell apoptosis by regulating HOXA7 in human ovarian cancer. | MiR-193a-5p suppresses cell proliferation and induces cell apoptosis by regulating HOXA7 in human ovarian cancer.
Wang S, Diao YJ, Zhu BB. | 11/21/2020 |
| Correlation of miR-181a and three HOXA genes as useful biomarkers in acute myeloid leukemia. | Correlation of miR-181a and three HOXA genes as useful biomarkers in acute myeloid leukemia.
Xu P, Zhou D, Yan G, Ouyang J, Chen B. | 10/3/2020 |
| Study found the miR-144-3p expression was reduced in neuroblastoma (NB) tissues and cell lines and resulted in the stimulation of cell proliferation, cell cycle progression, and cell migration in vitro. Homeobox protein A7 (HOXA7) was validated as a direct target of miR-144-3p. Results demonstrated the tumor suppressive role of miR-144-3p in NB. | microRNA-144-3p suppresses human neuroblastoma cell proliferation by targeting HOXA7.
Cao XY, Sun ZY, Zhang LJ, Chen MK, Yuan B. | 07/25/2020 |
| Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice. | The effect of lncRNA HOTAIR on chemoresistance of ovarian cancer through regulation of HOXA7.
Liu S, Lei H, Luo F, Li Y, Xie L. | 12/22/2018 |
| data suggest that HOXA7 could serve as a diagnostic marker for OSCC or a treatment target | The expression and significance of the HOXA7 gene in oral squamous cell carcinoma.
Duan X, Chen H, Ma H, Song Y. | 05/26/2018 |
| The homeodomain and N- and C-termini are critical to transcriptional activation by Hoxa1 protein. The N-terminus also modulates interaction with Pbx1a protein during DNA-binding. | Pentapeptide insertion mutagenesis of the Hoxa1 protein: mapping of transcription activation and DNA-binding regulatory domains.
Lambert B, Vandeputte J, Desmet PM, Hallet B, Remacle S, Rezsohazy R. | 03/7/2017 |
| HOXA7 might be a new gene candidate that influences the maturation of acute myeloid leukemia. | All-trans retinoic acid inhibits HOXA7 expression in leukemia cell NB4.
Guo Q, Jiang Q, Liu W, Bai Y. | 10/29/2016 |
| HOXA7 promotes cell proliferation, and these changes were mediated by cyclin E1/CDK2 | HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2.
Li Y, Yang XH, Fang SJ, Qin CF, Sun RL, Liu ZY, Jiang BY, Wu X, Li G. | 08/15/2015 |
| variants in the HOXA7 and HOXA9 genes are not common in Chinese women with Mullerian duct abnormalities | Mutation screening of HOXA7 and HOXA9 genes in Chinese women with Müllerian duct abnormalities.
Chen X, Mu Y, Li C, Li G, Zhao H, Qin Y, Chen ZJ. | 08/15/2015 |
| This finding contributes to our understanding of the role HOXA7 plays in regulating the proliferation of ER-positive cancer cells. | Homeobox A7 stimulates breast cancer cell proliferation by up-regulating estrogen receptor-alpha.
Zhang Y, Cheng JC, Huang HF, Leung PC. | 02/15/2014 |
| Hoxa7, Hoxa9 and Hox cofactor Meis1 were identified as AP-2alpha target genes, which are involved in myeloid leukemogenesis. | Transcription factor AP-2α regulates acute myeloid leukemia cell proliferation by influencing Hoxa gene expression.
Ding X, Yang Z, Zhou F, Wang F, Li X, Chen C, Li X, Hu X, Xiang S, Zhang J. | 02/15/2014 |
| Data show that up-regulation of the HOXA7, HOXA9, HOXA11, and PBX3 resulting from the down-regulation of miR-181 family members probably contribute to the poor prognosis of patients with nonfavorable cytogenetically abnormal AML (CA-AML). | Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Li Z, Huang H, Li Y, Jiang X, Chen P, Arnovitz S, Radmacher MD, Maharry K, Elkahloun A, Yang X, He C, He M, Zhang Z, Dohner K, Neilly MB, Price C, Lussier YA, Zhang Y, Larson RA, Le Beau MM, Caligiuri MA, Bullinger L, Valk PJ, Delwel R, Lowenberg B, Liu PP, Marcucci G, Bloomfield CD, Rowley JD, Chen J., Free PMC Article | 05/26/2012 |
| found evidence for association of bone geometry variation with an SNP in ENPP1, a gene in the mineralization pathway. The alteration of a binding site of the deregulator of extracellular matrix HOXA7 warrants further investigation | Hip geometry variation is associated with bone mineralization pathway gene variants: The Framingham Study.
Cheung CL, Livshits G, Zhou Y, Meigs JB, McAteer JB, Florez JC, Cupples LA, Demissie S, Kiel DP, Karasik D., Free PMC Article | 04/7/2012 |
| Taken together, these results support the notion that down-regulation of PCGF2 is sufficient to induce granulocytic differentiation of HL-60 cells via de-repression of HOXA7 gene expression. | Inhibition of PCGF2 enhances granulocytic differentiation of acute promyelocytic leukemia cell line HL-60 via induction of HOXA7.
Jo S, Lee H, Kim S, Hwang EM, Park JY, Kang SS, Chung H. | 01/28/2012 |
| Several targets of MLL fusions, MEIS1, HOXA7, HOXA9, and HOXA10 are functionally related and have been implicated in leukemias. Each of the four genes was knocked down separately in the precursor B-cell leukemic line RS4;11 expressing MLL-AF4. | Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.
Orlovsky K, Kalinkovich A, Rozovskaia T, Shezen E, Itkin T, Alder H, Ozer HG, Carramusa L, Avigdor A, Volinia S, Buchberg A, Mazo A, Kollet O, Largman C, Croce CM, Nakamura T, Lapidot T, Canaani E., Free PMC Article | 07/16/2011 |
| HOXA7, PIXT1 and PRRX1 homeobox genes have different patterns of expression in oral squamous cell carcinomas depending on its histological features. | In situ hybridization detection of homeobox genes reveals distinct expression patterns in oral squamous cell carcinomas.
Libório TN, Acquafreda T, Matizonkas-Antonio LF, Silva-Valenzuela MG, Ferraz AR, Nunes FD. | 05/28/2011 |
| A novel mechanistic role for HOXA7 in modulating granulosa cell proliferation via upregulation of EGFR. | Homeobox A7 increases cell proliferation by up-regulation of epidermal growth factor receptor expression in human granulosa cells.
Zhang Y, Huang Q, Cheng JC, Nishi Y, Yanase T, Huang HF, Leung PC., Free PMC Article | 10/23/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesMaternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. | 06/24/2009 |
| HOXA7 staining of tumor cell nuclei is correlated significantly with improved disease-specific survival, which is suggestive of the biological and potentially clinical importance of subcellular HOXA7 localization. | HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features.
Ota T, Gilks CB, Longacre T, Leung PC, Auersperg N. | 01/21/2010 |
| B-lineage development can proceed in t(4;11) leukemic blasts in the absence of HOX-A gene expression. | B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression.
Bertrand FE, Spengeman JD, Shah N, LeBien TW. | 01/21/2010 |
| Study reveals the preferential expression of HOXA7 by germinal vesicle (GV) oocytes. | cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles.
Huntriss J, Hinkins M, Picton HM. | 01/21/2010 |
| Hox A7-sustained expression disturbs the regulation of cell adhesive and migratory capacities on fibronectin during early differentiation. | Down-regulation of Hox A7 is required for cell adhesion and migration on fibronectin during early HL-60 monocytic differentiation.
Leroy P, Berto F, Bourget I, Rossi B. | 01/21/2010 |