| lncRNA HOTAIRM1 Activated by HOXA4 Drives HUVEC Proliferation Through Direct Interaction with Protein Partner HSPA5. | lncRNA HOTAIRM1 Activated by HOXA4 Drives HUVEC Proliferation Through Direct Interaction with Protein Partner HSPA5.
Zhou Y, Wu Q, Long X, He Y, Huang J., Free PMC Article | 02/1/2024 |
| High expression of <i>HOXA4</i> in patients with glioma indicates unfavorable clinical outcomes. | High expression of HOXA4 in patients with glioma indicates unfavorable clinical outcomes.
Yu Z, Liu Z, Lian X, Cheng X, Liu B, Zhang B, Wang H, Wang J, Li A, Ren Z, Pang B, Qian R, Gao Y., Free PMC Article | 11/12/2022 |
| MiR-150 Attenuates Maladaptive Cardiac Remodeling Mediated by Long Noncoding RNA MIAT and Directly Represses Profibrotic Hoxa4. | MiR-150 Attenuates Maladaptive Cardiac Remodeling Mediated by Long Noncoding RNA MIAT and Directly Represses Profibrotic Hoxa4.
Aonuma T, Moukette B, Kawaguchi S, Barupala NP, Sepúlveda MN, Frick K, Tang Y, Guglin M, Raman SV, Cai C, Liangpunsakul S, Nakagawa S, Kim IM., Free PMC Article | 05/7/2022 |
| Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma. | Expression Landscape and Functional Roles of HOXA4 and HOXA5 in Lung Adenocarcinoma.
Gao L, He RQ, Huang ZG, Li GS, Zeng JH, Hou JY, Luo JY, Dang YW, Zhou HF, Kong JL, Yang DP, Feng ZB, Chen G., Free PMC Article | 04/9/2022 |
| Aberrant DNA methylation at HOXA4 and HOXA5 genes are associated with resistance to imatinib mesylate among chronic myeloid leukemia patients. | Aberrant DNA methylation at HOXA4 and HOXA5 genes are associated with resistance to imatinib mesylate among chronic myeloid leukemia patients.
Elias MH, Azlan H, Sulong S, Baba AA, Ankathil R., Free PMC Article | 09/18/2021 |
| Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia. | Epigenome-wide analysis reveals functional modulators of drug sensitivity and post-treatment survival in chronic lymphocytic leukaemia.
Barrow TM, Nakjang S, Lafta F, Bilotkach K, Woodhouse L, Junge G, Tudhope SJ, Wallis JP, Marr H, Marshall S, Bown N, Willmore E, Strathdee G., Free PMC Article | 04/17/2021 |
| The results indicated that completely different sets of transcription factors coregulate HOXA4 and HOXD10 (but not HOXA9) and their expression-correlated genes. | Gene expression signatures for HOXA4, HOXA9, and HOXD10 reveal alterations in transcriptional regulatory networks in colon cancer.
Bhatlekar S, Ertel A, Gonye GE, Fields JZ, Boman BM. | 05/9/2020 |
| This study evaluated the methylation level and gene expression of HOXA4 and IGF1, which showed increased DNA methylation and decreased expression in breast cancer. HOXA4 and IGF1 are promising biomarkers for the early detection of breast cancer. | Microarray-based analysis of whole-genome DNA methylation profiling in early detection of breast cancer.
Li SY, Wu HC, Mai HF, Zhen JX, Li GS, Chen SJ. | 02/29/2020 |
| these data suggest that HOXA4 is a potential diagnostic and prognostic marker in lung cancer, and its overexpression could inhibit lung cancer progression in part by promoting GSK3beta transcription. | HOXA4, down-regulated in lung cancer, inhibits the growth, motility and invasion of lung cancer cells.
Cheng S, Qian F, Huang Q, Wei L, Fu Y, Du Y., Free PMC Article | 11/9/2019 |
| HOXA4 may play a role in regulating human growth by epigenetic mechanisms. | Hypomethylation of HOXA4 promoter is common in Silver-Russell syndrome and growth restriction and associates with stature in healthy children.
Muurinen M, Hannula-Jouppi K, Reinius LE, Söderhäll C, Merid SK, Bergström A, Melén E, Pershagen G, Lipsanen-Nyman M, Greco D, Kere J., Free PMC Article | 07/6/2019 |
| HOXA4/HOXB3 gene expression-based risk score may be useful for prognostic risk stratification and warrants prospective validation in HGSOC patients. | HOXA4/HOXB3 gene expression signature as a biomarker of recurrence in patients with high-grade serous ovarian cancer following primary cytoreductive surgery and first-line adjuvant chemotherapy.
Miller KR, Patel JN, Zhang Q, Norris EJ, Symanowski J, Michener C, Sehouli J, Braicu I, Destephanis DD, Sutker AP, Jones W, Livasy CA, Biscotti C, Ganapathi RN, Tait DL, Ganapathi MK. | 07/14/2018 |
| Overexpression of HOXA4 and HOXA9 contributes to self-renewal and overpopulation of stem cells in colorectal cancers. | Overexpression of HOXA4 and HOXA9 genes promotes self-renewal and contributes to colon cancer stem cell overpopulation.
Bhatlekar S, Viswanathan V, Fields JZ, Boman BM. | 11/25/2017 |
| HOXA4 increases short-term repopulation to higher levels than HOXB4, which may involve Notch signaling to induce self-renewal of primitive hematopoietic cells | HOXA4 provides stronger engraftment potential to short-term repopulating cells than HOXB4.
Fournier M, Lebert-Ghali CÉ, Bijl JJ., Free PMC Article | 08/13/2016 |
| The NK AML patients with NPM1 mutations exhibited elevated HOXA4 methylation and expression levels of HOXA5 and MEIS1 compared with the NPM1 wildtype patients. | Promoter DNA methylation and expression levels of HOXA4, HOXA5 and MEIS1 in acute myeloid leukemia.
Musialik E, Bujko M, Kober P, Grygorowicz MA, Libura M, Przestrzelska M, Juszczyński P, Borg K, Florek I, Jakóbczyk M, Siedlecki JA. | 03/26/2016 |
| promoter hypermethylation of HOXA4 gene could be an epigenetic mechanism mediating IM resistance in CML patients. | HOXA4 gene promoter hypermethylation as an epigenetic mechanism mediating resistance to imatinib mesylate in chronic myeloid leukemia patients.
Elias MH, Baba AA, Husin A, Sulong S, Hassan R, Sim GA, Abdul Wahid SF, Ankathil R., Free PMC Article | 09/7/2013 |
| HOXA4 showed nuclear & perinuclear staining in endothelial & smooth muscle cells in aorta. Spatial variation in expression in human aortas persisted into adulthood. Downregulation of HOXA4 expression was associated with abdominal aortic aneurysm. | Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms.
Lillvis JH, Erdman R, Schworer CM, Golden A, Derr K, Gatalica Z, Cox LA, Shen J, Vander Heide RS, Lenk GM, Hlavaty L, Li L, Elmore JR, Franklin DP, Gray JL, Garvin RP, Carey DJ, Lancaster WD, Tromp G, Kuivaniemi H., Free PMC Article | 10/8/2011 |
| Studies suggest that HOXA4, HOXA5 and HOXB4 provide the spatial information needed to restrict the response to signals from the notochord, and not up regulated in pancreatic cancer. | HOX genes in pancreatic development and cancer.
Gray S, Pandha HS, Michael A, Middleton G, Morgan R. | 10/1/2011 |
| Results confirm that HOXA4 inhibits cell motility, show that it suppresses cell spreading and filopodia formation while enhancing cell-cell adhesion, and suggest a role for beta1 integrin in mediating these changes. | Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin.
Klausen C, Leung PC, Auersperg N. | 01/21/2010 |
| combination of low HOXA4 and low MEIS1 gene expression is a favourable predictor for outcome in all AML patients and that the expression levels are governed by the methylation state of these genes. | The combined expression of HOXA4 and MEIS1 is an independent prognostic factor in patients with AML.
Zangenberg M, Grubach L, Aggerholm A, Silkjaer T, Juhl-Christensen C, Nyvold CG, Kjeldsen E, Ommen HB, Hokland P. | 01/21/2010 |
| analysis of the role of deregulated PcG genes in acute myeloid leukemia, and the downstream PcG targets HOXA4, HOXA9 and MEIS1 | Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia.
Grubach L, Juhl-Christensen C, Rethmeier A, Olesen LH, Aggerholm A, Hokland P, Ostergaard M. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesHigh-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias.
Chen T, Li Q, Xu J, Ding K, Wang Y, Wang W, Li S, Shen Y. | 03/13/2008 |
| aberrant DNA methylation may have a major role in the control of HOXA4 gene expression in chronic lymphocytic leukemia | Promoter hypermethylation silences expression of the HoxA4 gene and correlates with IgVh mutational status in CLL.
Strathdee G, Sim A, Parker A, Oscier D, Brown R. | 01/21/2010 |
| upregulated significantly in acute myeloid leukemia patients with a white blood cell count higher than 30 x 10(9)/L cells. | Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.
Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S. | 01/21/2010 |