| DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response. | DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response.
Jiao H, James SJ, Png CW, Cui C, Li H, Li L, Chia WN, Min N, Li W, Claser C, Rénia L, Wang H, Chen MI, Chu JJH, Tan KSW, Deng Y, Zhang Y., Free PMC Article | 03/15/2024 |
| Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease. | Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer's Disease.
Wang E, Pan AL, Bagchi P, Rangaraju S, Seyfried NT, Ehrlich ME, Salton SR, Zhang B., Free PMC Article | 02/12/2024 |
| Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis. | Identification of DUSP4/6 overexpression as a potential rheostat to NRAS-induced hepatocarcinogenesis.
Klemm S, Evert K, Utpatel K, Muggli A, Simile MM, Chen X, Evert M, Calvisi DF, Scheiter A., Free PMC Article | 11/15/2023 |
| DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90beta. | DUSP4 promotes esophageal squamous cell carcinoma progression by dephosphorylating HSP90β.
Zhou L, Yao N, Yang L, Liu K, Qiao Y, Huang C, Du R, Yeung YT, Liu W, Cheng D, Dong Z, Li X. | 06/7/2023 |
| Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces beta-Amyloid Load in Males and Females. | Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females.
Pan AL, Audrain M, Sakakibara E, Joshi R, Zhu X, Wang Q, Wang M, Beckmann ND, Schadt EE, Gandy S, Zhang B, Ehrlich ME, Salton SR., Free PMC Article | 12/31/2022 |
| Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease. | Metabolic Impact of MKP-2 Upregulation in Obesity Promotes Insulin Resistance and Fatty Liver Disease.
Fernando S, Sellers J, Smith S, Bhogoju S, Junkins S, Welch M, Willoughby O, Ghimire N, Secunda C, Barmanova M, Kumer SC, Min K, Lawan A., Free PMC Article | 07/2/2022 |
| Mitogen-activated protein kinase phosphatase-2 deletion modifies ventral tegmental area function and connectivity and alters reward processing. | Mitogen-activated protein kinase phosphatase-2 deletion modifies ventral tegmental area function and connectivity and alters reward processing.
Pytka K, Dawson N, Tossell K, Ungless MA, Plevin R, Brett RR, Bushell TJ. | 07/17/2021 |
| MKP-2 has the potential to play a major role in regulating RA due to a direct effect on neutrophil function, with the potential to effect macrophages, osteoclast formation and bone development. | Novel protective role for MAP kinase phosphatase 2 in inflammatory arthritis.
Schroeder J, Ross K, McIntosh K, Jabber S, Woods S, Crowe J, Patterson Kane J, Alexander J, Lawrence C, Plevin R., Free PMC Article | 04/18/2020 |
| Dusp4 was found to be expressed in skeletal muscle and plays a role in the regulation of muscle cell differentiation. | Dual-specificity phosphatase 4 is upregulated during skeletal muscle atrophy and modulates extracellular signal-regulated kinase activity.
Haddock AN, Labuzan SA, Haynes AE, Hayes CS, Kakareka KM, Waddell DS. | 12/28/2019 |
| Transcriptome profiling reveals that MKP-2 regulates macrophage development showing candidate targets from monocyte-to-macrophage differentiation and macrophage proliferation. However, it is unclear whether effects upon ERK signalling are able to explain the effects of DUSP-4 deletion on macrophage function. | Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and Function.
Neamatallah T, Jabbar S, Tate R, Schroeder J, Shweash M, Alexander J, Plevin R., Free PMC Article | 12/28/2019 |
| compound-heterozygous deletion of Dok2 and Dusp4 in mice resulted in lung tumorigenesis with short latency and high incidence, and that their co-deletion synergistically activated MAPK signaling and promoted cell proliferation. | Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
Chen M, Zhang J, Berger AH, Diolombi MS, Ng C, Fung J, Bronson RT, Castillo-Martin M, Thin TH, Cordon-Cardo C, Plevin R, Pandolfi PP., Free PMC Article | 11/9/2019 |
| Signalling via ERK1/2 and tuning by its negative regulator DUSP4 are critical elements of the vasoactive intestinal peptide-directed circadian re-programming. | Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling.
Hamnett R, Crosby P, Chesham JE, Hastings MH., Free PMC Article | 04/6/2019 |
| we show that the H222P amino acid substitution in lamin A enhances its binding to ERK1/2 and increases sequestration at the nuclear envelope. Finally, we show that genetic deletion of Dusp4 has beneficial effects on heart function and prolongs survival in LmnaH222P/H222P mice. These results further establish Dusp4 as a key contributor to the pathogenesis of LMNA cardiomyopathy and a potential target for drug therapy. | Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.
Choi JC, Wu W, Phillips E, Plevin R, Sera F, Homma S, Worman HJ., Free PMC Article | 02/23/2019 |
| Data provide evidence that repression of the ERK inhibitor DUSP4 by BMI1 is dependent on a more accessible chromatin configuration in G4 MB cells with low CHD7 expression. | Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.
Badodi S, Dubuc A, Zhang X, Rosser G, Da Cunha Jaeger M, Kameda-Smith MM, Morrissy AS, Guilhamon P, Suetterlin P, Li XN, Guglielmi L, Merve A, Farooq H, Lupien M, Singh SK, Basson MA, Taylor MD, Marino S., Free PMC Article | 07/21/2018 |
| study suggests that MKP-2 is essential to the pathogenic response of EAE, and it acts mainly via regulating the important antigen presenting DC function and T cell activation. | MAP kinase phosphatase 2 deficient mice develop attenuated experimental autoimmune encephalomyelitis through regulating dendritic cells and T cells.
Barbour M, Plevin R, Jiang HR., Free PMC Article | 06/16/2018 |
| SALL4 associated with the NuRD co-repressor and repressed expression of the tumor suppressor genes Foxl1 and Dusp4. | Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes.
Chan AL, La HM, Legrand JMD, Mäkelä JA, Eichenlaub M, De Seram M, Ramialison M, Hobbs RM., Free PMC Article | 05/19/2018 |
| domain-mapping results showed that both the substrate-interacting and the phosphatase domains of DUSP4 were required for its optimal interaction with STAT5, while the coiled-coil domain of STAT5 appeared to hinder this interaction | Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization.
Hsiao WY, Lin YC, Liao FH, Chan YC, Huang CY., Free PMC Article | 07/16/2016 |
| MKP-2 knock-out mice show deficits in working memory and spatial reference. | Mitogen-Activated Protein Kinase Phosphatase-2 Deletion Impairs Synaptic Plasticity and Hippocampal-Dependent Memory.
Abdul Rahman NZ, Greenwood SM, Brett RR, Tossell K, Ungless MA, Plevin R, Bushell TJ., Free PMC Article | 07/2/2016 |
| DUSP4 is crucial for neuronal differentiation and functions in the neurogenesis of embryonic stem cells. | DUSP4 regulates neuronal differentiation and calcium homeostasis by modulating ERK1/2 phosphorylation.
Kim SY, Han YM, Oh M, Kim WK, Oh KJ, Lee SC, Bae KH, Han BS., Free PMC Article | 11/28/2015 |
| MKP-1 and MKP-2 stability is regulated by ERK-mediated phosphorylation through a degradation pathway independent of polyubiquitination | Post-translational regulation of mitogen-activated protein kinase phosphatase (MKP)-1 and MKP-2 in macrophages following lipopolysaccharide stimulation: the role of the C termini of the phosphatases in determining their stability.
Crowell S, Wancket LM, Shakibi Y, Xu P, Xue J, Samavati L, Nelin LD, Liu Y., Free PMC Article | 12/27/2014 |
| Loss of MKP-2 expression is associated with enhanced susceptibility to parasite infection. | MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice.
Woods S, Schroeder J, McGachy HA, Plevin R, Roberts CW, Alexander J., Free PMC Article | 05/10/2014 |
| LH/hCG tightly regulates MKP-2 expression, which modulates the induction of CYP11A1 by 8Br-cAMP. | MAPK phosphatase-2 (MKP-2) is induced by hCG and plays a role in the regulation of CYP11A1 expression in MA-10 Leydig cells.
Gómez NV, Gorostizaga AB, Mori Sequeiros García MM, Brion L, Acquier A, González-Calvar SI, Méndez CF, Podestá EJ, Paz C. | 05/11/2013 |
| Dusp1 and Dusp4 are cardioprotective genes that play a critical role in the heart by dampening p38 MAPK signaling that would otherwise reduce contractility and induce cardiomyopathy. | Unrestrained p38 MAPK activation in Dusp1/4 double-null mice induces cardiomyopathy.
Auger-Messier M, Accornero F, Goonasekera SA, Bueno OF, Lorenz JN, van Berlo JH, Willette RN, Molkentin JD., Free PMC Article | 03/2/2013 |
| Loss of MKP-2 regulates early inflammation in acute lung injury. | Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury.
Cornell TT, Fleszar A, McHugh W, Blatt NB, Le Vine AM, Shanley TP., Free PMC Article | 10/20/2012 |
| Increased DUSP4 expression in activated T cells in the elderly in part accounts for defective adaptive immune responses. | Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age.
Yu M, Li G, Lee WW, Yuan M, Cui D, Weyand CM, Goronzy JJ., Free PMC Article | 06/9/2012 |