| HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway. | HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
Lv J, Li K, Yu H, Han J, Zhuang J, Yu R, Cheng Y, Song Q, Bai K, Cao Q, Yang H, Yang X, Lu Q., Free PMC Article | 03/1/2023 |
| The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma. | The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma.
Wu Q, Zhang H, Yang D, Min Q, Wang Y, Zhang W, Zhan Q., Free PMC Article | 08/27/2022 |
| hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis. | hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.
Xu P, Zhang J, Wang M, Liu B, Li R, Li H, Zhai N, Liu W, Lv C, Song X., Free PMC Article | 06/11/2022 |
| FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer. | FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer.
Ji M, Zhao Z, Li Y, Xu P, Shi J, Li Z, Wang K, Huang X, Ji J, Liu W, Liu B., Free PMC Article | 01/29/2022 |
| lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization. | lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization.
Wang H, Ma P, Liu P, Guo D, Liu Z, Zhang Z. | 01/8/2022 |
| HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1. | HNRNPL affects the proliferation and apoptosis of colorectal cancer cells by regulating PD-L1.
Zhao Y, Wang Y, Wang Q. | 11/6/2021 |
| HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer. | HNRNPL Is Identified and Validated as a Prognostic Biomarker Associated with Microsatellite Instability in Human Gastric Cancer.
Yu X, Cao F, Yu Y, Li Y, Zhang J, Xu T, Di Q, Wu G, Zhang Z, Wang R, Li Y. | 10/23/2021 |
| The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells. | The MTNR1A mRNA is stabilized by the cytoplasmic hnRNPL in renal tubular cells.
Huang YS, Lu KC, Chao HW, Chen A, Chao TK, Guo CY, Hsieh HY, Shih HM, Sytwu HK, Wu CC. | 09/18/2021 |
| Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1. | Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1.
Schmitt HM, Johnson WM, Aboobakar IF, Strickland S, Gomez-Caraballo M, Parker M, Finnegan L, Corcoran DL, Skiba NP, Allingham RR, Hauser MA, Stamer WD., Free PMC Article | 08/28/2021 |
| A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3. | A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3.
He X, Chai P, Li F, Zhang L, Zhou C, Yuan X, Li Y, Yang J, Luo Y, Ge S, Zhang H, Jia R, Fan X., Free PMC Article | 05/29/2021 |
| Long noncoding RNA SPRY4-IT1 promotes proliferation and metastasis of hepatocellular carcinoma via mediating TNF signaling pathway. | Long noncoding RNA SPRY4-IT1 promotes proliferation and metastasis of hepatocellular carcinoma via mediating TNF signaling pathway.
Ma W, Chen X, Wu X, Li J, Mei C, Jing W, Teng L, Tu H, Jiang X, Wang G, Chen Y, Wang K, Wang H, Wei Y, Liu Z, Yuan Y. | 03/13/2021 |
| Heterogeneous nuclear ribonucleoprotein (hnRNPL) in cancer. | Heterogeneous nuclear ribonucleoprotein (hnRNPL) in cancer.
Gu J, Chen Z, Chen X, Wang Z. | 01/16/2021 |
| Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region. | Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region.
Sun C, Liu M, Chang J, Yang D, Zhao B, Wang H, Zhou G, Weng C, Yu L., Free PMC Article | 10/31/2020 |
| hnRNP L is critical for the recruitment of the DNA repair factors in oxaliplatin-induced double-strand breaks . | Heterogeneous nuclear ribonucleoprotein L facilitates recruitment of 53BP1 and BRCA1 at the DNA break sites induced by oxaliplatin in colorectal cancer.
Hu W, Lei L, Xie X, Huang L, Cui Q, Dang T, Liu GL, Li Y, Sun X, Zhou Z., Free PMC Article | 08/12/2020 |
| Knockdown of heterogeneous nuclear ribonucleoprotein L (hnRNP L) sensitizes the human U937 monocytic cells under hypoxia stress but not in normoxia via inducing cell apoptosis partially due to the reduced translation of hnRNP L target mRNAs. | hnRNP L-mediated RNA switches function as a hypoxia-induced translational regulon.
Venkata Subbaiah KC, Wu J, Potdar A, Yao P., Free PMC Article | 07/11/2020 |
| The results suggest that the CALIC/hnRNP-L complex enhances the metastatic potential of colon cancer cells. | The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis.
Kawasaki Y, Miyamoto M, Oda T, Matsumura K, Negishi L, Nakato R, Suda S, Yokota N, Shirahige K, Akiyama T., Free PMC Article | 05/2/2020 |
| Study provides a panoramic view of enhancer RNAs (eRNAs) transcription and categorization of eRNAs. Master transcription factor MyoD is crucial in activating eRNA production. Super enhancer (se) generated seRNA-1 and -2 promote myogenic differentiation in vitro and in vivo by binding to heterogeneous nuclear ribonucleoprotein L (hnRNPL). | MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation.
Zhao Y, Zhou J, He L, Li Y, Yuan J, Sun K, Chen X, Bao X, Esteban MA, Sun H, Wang H., Free PMC Article | 04/11/2020 |
| The data demonstrate that the hnRNP L and its paralog, LL, differentially control hormone gene expression programs at multiple levels, and hnRNP L in particular is critical for protecting the transcriptome from aberrant usage of intronic sequences. | Multilevel Differential Control of Hormone Gene Expression Programs by hnRNP L and LL in Pituitary Cells.
Lei L, Cao W, Liu L, Das U, Wu Y, Liu G, Sohail M, Chen Y, Xie J., Free PMC Article | 06/22/2019 |
| CASC9:HNRNPL complex is a clinically relevant viability-associated lncRNA/protein complex which affects AKT signaling and DNA damage sensing in hepatocellular carcinoma. | The Long Noncoding RNA Cancer Susceptibility 9 and RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein L Form a Complex and Coregulate Genes Linked to AKT Signaling.
Klingenberg M, Groß M, Goyal A, Polycarpou-Schwarz M, Miersch T, Ernst AS, Leupold J, Patil N, Warnken U, Allgayer H, Longerich T, Schirmacher P, Boutros M, Diederichs S. | 03/30/2019 |
| IRF1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately regulate CEACAM1 transcription, alternative splicing, and translation and may significantly contribute to CEACAM1 silencing in cancer. | Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1.
Dery KJ, Silver C, Yang L, Shively JE., Free PMC Article | 01/26/2019 |
| High expression of HnRNP L is associated with oral squamous cell carcinoma. | HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells.
Jia R, Zhang S, Liu M, Zhang Y, Liu Y, Fan M, Guo J., Free PMC Article | 06/30/2018 |
| uc.345 could upregulate the hnRNPL expression and that inhibition of (hnRNPL) dampens the tumorigenesis capability of uc.345. | Long noncoding RNA uc.345 promotes tumorigenesis of pancreatic cancer by upregulation of hnRNPL expression.
Liu C, Wang J, Yuan X, Qian W, Zhang B, Shi M, Xie J, Shen B, Xu H, Hou Z, Chen H., Free PMC Article | 02/17/2018 |
| HnRNP L is a novel regulator of HPV16 RNA processing.HnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner. | hnRNP L controls HPV16 RNA polyadenylation and splicing in an Akt kinase-dependent manner.
Kajitani N, Glahder J, Wu C, Yu H, Nilsson K, Schwartz S., Free PMC Article | 10/28/2017 |
| Translation of VEGFA mRNA in myeloid cells is dictated by a bi-directional interaction between miR-574-3p, a CA-rich microRNA, and hnRNP L. In normoxia, miR-574-3p, acting as a decoy, binds cytoplasmic hnRNP L and prevents its binding to the CARE and stimulation of VEGFA mRNA translation, simultaneously permitting miR-297-mediated translational silencing. | Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis.
Yao P, Wu J, Lindner D, Fox PL., Free PMC Article | 10/14/2017 |
| High HNRNPL expression is associated with prostate cancer. | HnRNP-L promotes prostate cancer progression by enhancing cell cycling and inhibiting apoptosis.
Zhou X, Li Q, He J, Zhong L, Shu F, Xing R, Lv D, Lei B, Wan B, Yang Y, Wu H, Mao X, Zou Y., Free PMC Article | 10/7/2017 |