| Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition. | Heterogeneous nuclear ribonucleoprotein F deficiency in mouse podocyte promotes podocytopathy mediated by methyltransferase-like 14 nuclear translocation resulting in Sirtuin 1 gene inhibition.
Liao MC, Lo CS, Pang YC, Yang WX, Su K, Zhao XP, Miyata KN, Peng J, Ingelfinger JR, Chan JSD, Zhang SL. | 04/16/2024 |
| The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells. | The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells.
Chen X, Yang HT, Zhang B, Phillips JW, Cheng D, Rigo F, Witte ON, Xing Y, Black DL., Free PMC Article | 07/10/2023 |
| Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration. | Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.
Ryan VH, Perdikari TM, Naik MT, Saueressig CF, Lins J, Dignon GL, Mittal J, Hart AC, Fawzi NL., Free PMC Article | 10/9/2021 |
| Study in thyroid cancer series enriched with poor prognosis cases and found hsa-miR139-5p downregulation as a bona fide poor-prognostic factor. Exogenous hsa-miR-139-5p expression repressed procancer features of thyroid cancer cells. Proteomic analysis revealed that the alternative splicing factor HNRNPF is a putative hsa-miR-139-5p. | Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing.
Montero-Conde C, Graña-Castro O, Martín-Serrano G, Martínez-Montes ÁM, Zarzuela E, Muñoz J, Torres-Perez R, Pita G, Cordero-Barreal A, Leandro-García LJ, Letón R, López de Silanes I, Guadalix S, Pérez-Barrios A, Hawkins F, Guerrero-Álvarez A, Álvarez-Escolá C, Regojo-Zapata RM, Calsina B, Remacha L, Roldán-Romero JM, Santos M, Lanillos J, Jordá M, Riesco-Eizaguirre G, Zafon C, González-Neira A, Blasco MA, Al-Shahrour F, Rodríguez-Antona C, Cascón A, Robledo M. | 02/22/2020 |
| The overexpression of hnRNP-F caused an increase in the stability of Snail1 mRNA. Our RNA chip analysis revealed that hnRNP-F could combine with Snail1 mRNA, and we further demonstrated that hnRNP-F could directly bind to the 3' untranslated region (3' UTR) of Snail1 mRNA to enhance its stability. | HnRNP-F regulates EMT in bladder cancer by mediating the stabilization of Snail1 mRNA by binding to its 3' UTR.
Li F, Zhao H, Su M, Xie W, Fang Y, Du Y, Yu Z, Hou L, Tan W., Free PMC Article | 01/11/2020 |
| this study is the first to identify hnRNP F/H and K as regulators of Mcl-1 alternative splicing. | Regulation of Mcl-1 alternative splicing by hnRNP F, H1 and K in breast cancer cells.
Tyson-Capper A, Gautrey H., Free PMC Article | 09/14/2019 |
| Binding of the hnRNP F to the YAP 3'UTR was demonstrated by Cross-linked RNA Immunoprecipitation. hnRNP F and hnRNP U negatively regulate YAP expression. | Heterogeneous ribonucleoprotein F regulates YAP expression via a G-tract in 3'UTR.
Chu WK, Hung LM, Hou CW, Chen JK. | 08/17/2019 |
| FOXP3 represses the ability of hnRNPF to bind to its target pre-mRNA and thus modulates RNA alternative splicing | FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing.
Du J, Wang Q, Ziegler SF, Zhou B., Free PMC Article | 01/19/2019 |
| hnRNP H/F are important for maintenance and differentiation of embryonic stem cells and that this at least in part reflects a switch in TCF3 alternative splicing that leads to repression of CDH1/E-cadherin. | TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency.
Yamazaki T, Liu L, Lazarev D, Al-Zain A, Fomin V, Yeung PL, Chambers SM, Lu CW, Studer L, Manley JL., Free PMC Article | 10/6/2018 |
| Results from a study on gene expression variability markers in early-stage human embryos shows that HNRNPF is a putative marker for the 3-day, 8-cell embryo stage. | Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrenté L, Mar JC., Free PMC Article | 07/23/2018 |
| heterogeneous nuclear ribonucleoprotein F (hnRNPF) regulates G-quadruplex-associated alternative splicing across the transcriptome. | RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF.
Huang H, Zhang J, Harvey SE, Hu X, Cheng C., Free PMC Article | 02/3/2018 |
| Simulation results demonstrate that the RNA binding domain qRRM2 of hnRNP F binds strongly with G-tract RNA, but any mutation of the G-tract leads to a drastic reduction of the binding free energy. | Molecular insights into the specific recognition between the RNA binding domain qRRM2 of hnRNP F and G-tract RNA: A molecular dynamics study.
Wang L, Yan F. | 11/18/2017 |
| Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and FOXO3alpha than nondiabetic kidneys. | Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene Expression and Attenuates Nephropathy Progression in Diabetic Mice.
Lo CS, Shi Y, Chenier I, Ghosh A, Wu CH, Cailhier JF, Ethier J, Lattouf JB, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD., Free PMC Article | 09/2/2017 |
| hnRNP F is a co-factor in a subset of tristetraprolin/BRF1/BRF2-mediated mRNA decay. | hnRNP F complexes with tristetraprolin and stimulates ARE-mRNA decay.
Reznik B, Clement SL, Lykke-Andersen J., Free PMC Article | 02/21/2015 |
| These data point to a functional interaction between hnRNP F and SRSF1 as a mutant that eliminates SRSF1 binding to exon 11, or a SRSF1 knockdown, which prevents the stimulatory effect of hnRNP F over expression. | hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.
Talukdar I, Sen S, Urbano R, Thompson J, Yates JR 3rd, Webster NJ., Free PMC Article | 04/7/2012 |
| this result suggests that hnRNP F directs formation of the exon 4 minus variant of ENOX2. | hnRNP F directs formation of an exon 4 minus variant of tumor-associated NADH oxidase (ENOX2).
Tang X, Kane VD, Morré DM, Morré DJ. | 02/25/2012 |
| The study shows solution structures of the three quasi-RNA-recognition motifs of heterogeneous nuclear ribonucleoprotein F in complex with G-tract RNA. | Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs.
Dominguez C, Fisette JF, Chabot B, Allain FH. | 08/2/2010 |
| heterogeneous ribonucleoprotein F is involved in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway | Involvement of heterogeneous ribonucleoprotein F in the regulation of cell proliferation via the mammalian target of rapamycin/S6 kinase 2 pathway.
Goh ET, Pardo OE, Michael N, Niewiarowski A, Totty N, Volkova D, Tsaneva IR, Seckl MJ, Gout I., Free PMC Article | 06/28/2010 |
| Results suggest that hnRNP H and F are nuclear shuttling proteins whose posttranslational modifications may alter interaction with transportin 1, nuclear localization, and hence function. | A glycine-rich domain of hnRNP H/F promotes nucleocytoplasmic shuttling and nuclear import through an interaction with transportin 1.
Van Dusen CM, Yee L, McNally LM, McNally MT., Free PMC Article | 06/14/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| hnRNPH and F regulate DM20 splicing by recruiting U1snRNP and hnRNPH plays a primary role in DM20 splice site selection in vivo | Heterogeneous nuclear ribonucleoproteins H and F regulate the proteolipid protein/DM20 ratio by recruiting U1 small nuclear ribonucleoprotein through a complex array of G runs.
Wang E, Cambi F., Free PMC Article | 01/21/2010 |
| The solution structure of the three quasi RNA recognition motifs of hnRNP F and identification of the residues that are important for the interaction with the Bcl-x RNA. | NMR structure of the three quasi RNA recognition motifs (qRRMs) of human hnRNP F and interaction studies with Bcl-x G-tract RNA: a novel mode of RNA recognition.
Dominguez C, Allain FH., Free PMC Article | 01/21/2010 |
| high levels of hnRNP F are present in premalignant and malignant stages of colorectal cancer, reflecting a role for this protein early in colorectal tumorigenesis | Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer.
Balasubramani M, Day BW, Schoen RE, Getzenberg RH. | 01/21/2010 |
| Shows that hnRNPF regulates the 3' end cleavage reaction. | hnRNP F influences binding of a 64-kilodalton subunit of cleavage stimulation factor to mRNA precursors in mouse B cells.
Veraldi KL, Arhin GK, Martincic K, Chung-Ganster LH, Wilusz J, Milcarek C., Free PMC Article | 05/3/2003 |