| Contribution of ONECUT1 variants to different forms of non-autoimmune diabetes mellitus in Italian patients. | Contribution of ONECUT1 variants to different forms of non-autoimmune diabetes mellitus in Italian patients.
Prudente S, Andreozzi F, Mercuri L, Alberico F, Di Giamberardino A, Mannino GC, Ludovico O, Piscitelli P, Di Paola R, Morano S, Penno G, Carella M, De Cosmo S, Trischitta V, Barbetti F. | 09/10/2022 |
| Mutations and variants of ONECUT1 in diabetes. | Mutations and variants of ONECUT1 in diabetes.
Philippi A, Heller S, Costa IG, Senée V, Breunig M, Li Z, Kwon G, Russell R, Illing A, Lin Q, Hohwieler M, Degavre A, Zalloua P, Liebau S, Schuster M, Krumm J, Zhang X, Geusz R, Benthuysen JR, Wang A, Chiou J, Gaulton K, Neubauer H, Simon E, Klein T, Wagner M, Nair G, Besse C, Dandine-Roulland C, Olaso R, Deleuze JF, Kuster B, Hebrok M, Seufferlein T, Sander M, Boehm BO, Oswald F, Nicolino M, Julier C, Kleger A., Free PMC Article | 01/1/2022 |
| Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. | Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.
Heller S, Li Z, Lin Q, Geusz R, Breunig M, Hohwieler M, Zhang X, Nair GG, Seufferlein T, Hebrok M, Sander M, Julier C, Kleger A, Costa IG., Free PMC Article | 12/25/2021 |
| HNF6 promoted colorectal cancer cell proliferation and tumor growth, and may contribute to liver metastasis via conferring cell resistance to anoikis. | HNF6 promotes tumor growth in colorectal cancer and enhances liver metastasis in mouse model.
Jiang K, Jiao Y, Liu Y, Fu D, Geng H, Chen L, Chen H, Shen X, Sun L, Ding K. | 03/21/2020 |
| Data show that chromatin regions that contain the ONECUT motif were in- or lowly accessible in fibroblasts and became accessible after the overexpression of ONECUT1, ONECUT2 or ONECUT3. | ONECUT transcription factors induce neuronal characteristics and remodel chromatin accessibility.
van der Raadt J, van Gestel SHC, Nadif Kasri N, Albers CA., Free PMC Article | 11/30/2019 |
| Reduced HNF6 expression is associated with metastasis of cholangiocarcinoma. | Hepatocyte nuclear factor 6 inhibits the growth and metastasis of cholangiocarcinoma cells by regulating miR-122.
Zhu H, Mi Y, Jiang X, Zhou X, Li R, Wei Z, Jiang H, Lu J, Sun X. | 09/3/2016 |
| HNF6 is a novel host factor that can restrict hepatitis B virus replication via both transcriptional and posttranscriptional mechanisms. | Inhibition of hepatitis B virus gene expression and replication by hepatocyte nuclear factor 6.
Hao R, He J, Liu X, Gao G, Liu D, Cui L, Yu G, Yu W, Chen Y, Guo D., Free PMC Article | 05/30/2015 |
| The negative correlation between HNF6 expression and pancreatic cancer progression suggests that HNF6 maintains pancreatic epithelial homeostasis, and that its loss contributes to the progression from intraepithelial neoplasms to ductal adenocarcinoma. | Loss of HNF6 expression correlates with human pancreatic cancer progression.
Pekala KR, Ma X, Kropp PA, Petersen CP, Hudgens CW, Chung CH, Shi C, Merchant NB, Maitra A, Means AL, Gannon MA., Free PMC Article | 06/14/2014 |
| HNF6 plays an important role in the gene regulation of CYP3A4 during development from the fetal period to the postnatal period. | Hepatocyte nuclear factor 6 activates the transcription of CYP3A4 in hepatocyte-like cells differentiated from human induced pluripotent stem cells.
Sasaki T, Takahashi S, Numata Y, Narita M, Tanaka Y, Kumagai T, Kondo Y, Matsunaga T, Ohmori S, Nagata K. | 02/1/2014 |
| HNF6 inhibits EMT, cell migration, and invasive growth through a mechanism involving the transcriptional activation of p53. | Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition.
Yuan XW, Wang DM, Hu Y, Tang YN, Shi WW, Guo XJ, Song JG., Free PMC Article | 01/4/2014 |
| Mutations at the -5/-6 site of the F9 promotor account for the majority of hemophilia B Leyden cases and disrupt the binding of ONECUT1 and ONECUT2. | A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B Leyden.
Funnell AP, Wilson MD, Ballester B, Mak KS, Burdach J, Magan N, Pearson RC, Lemaigre FP, Stowell KM, Odom DT, Flicek P, Crossley M., Free PMC Article | 08/31/2013 |
| HNF6 and Sox9 are new biomarkers of pancreatic acinar-to-ductal metaplasia and constitute candidate targets for preventive treatment in cases when acinar-to-ductal metaplasia may lead to cancer. | Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.
Prévot PP, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, Sempoux C, Xu X, Roelants V, Hald J, Bertrand L, Heimberg H, Konieczny SF, Dor Y, Lemaigre FP, Jacquemin P., Free PMC Article | 01/26/2013 |
| Hepatocyte nuclear factor 6 is one of the liver-enriched transcription factors, it utilizes the bipartite onecut-homeodomain sequence to localize to the nuclear compartment and bind specific DNA sequences of numerous target gene promoters | Pathophysiologic role of hepatocyte nuclear factor 6.
Wang K, Holterman AX. | 02/25/2012 |
| functional knockdown of FOXA2 recovered HNF6 activity and inhibited growth of tumor-cells and may possibly represent a novel therapeutic target in primary and secondary liver malignancies | Inhibition of the liver enriched protein FOXA2 recovers HNF6 activity in human colon carcinoma and liver hepatoma cells.
Lehner F, Kulik U, Klempnauer J, Borlak J., Free PMC Article | 03/12/2011 |
| Results suggest that HNF-6 is a novel target of small heterodimer partner in the regulation of gluconeogenesis. | Orphan nuclear receptor SHP interacts with and represses hepatocyte nuclear factor-6 (HNF-6) transactivation.
Lee YS, Kim DK, Kim YD, Park KC, Shong M, Seong HA, Ha HJ, Choi HS. | 01/21/2010 |
| ONECUT1 expression is lost in pancreatic cancer cells, suggesting a tumor suppressor function in this malignancy. | Loss of ONECUT1 expression in human pancreatic cancer cells.
Jiang X, Zhang W, Kayed H, Zheng P, Giese NA, Friess H, Kleeff J. | 01/21/2010 |
| HNF6 DNA binding is selectively abrogated through lack of post-translational modification and interaction with FOXA2. Targeting of FOXA2 and HNF6 may therefore enable mechanism-based therapy for colorectal liver metastases | The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases.
Lehner F, Kulik U, Klempnauer J, Borlak J. | 01/21/2010 |
| A comparision of gene expression patterns induced by hepatic nuclear factors, HNF6, HNF4alpha and HNF1beta, in a pancreatic beta-cell line. | Pattern of genes influenced by conditional expression of the transcription factors HNF6, HNF4alpha and HNF1beta in a pancreatic beta-cell line.
Thomas H, Senkel S, Erdmann S, Arndt T, Turan G, Klein-Hitpass L, Ryffel GU., Free PMC Article | 01/21/2010 |
| identifed systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II in human liver and pancreatic islets | Control of pancreas and liver gene expression by HNF transcription factors.
Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA., Free PMC Article | 01/21/2010 |
| HNF6 has a role as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2 | Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.
Rausa FM, Tan Y, Costa RH., Free PMC Article | 01/21/2010 |
| HNF6 protein stability is controlled by CBP acetylation | Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator.
Rausa FM 3rd, Hughes DE, Costa RH. | 01/21/2010 |
| These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells. | Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.
Maestro MA, Boj SF, Luco RF, Pierreux CE, Cabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J. | 01/21/2010 |