| Genetic Polymorphisms in the HMGCR Gene and Associations with Cognitive Decline in Parkinson's Disease Patients. | Genetic Polymorphisms in the HMGCR Gene and Associations with Cognitive Decline in Parkinson's Disease Patients.
Pierzchlińska A, Sławek J, Kwaśniak-Butowska M, Malinowski D, Komaniecka N, Mak M, Czerkawska A, Kukowka A, Białecka M., Free PMC Article | 08/31/2024 |
| Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions. | Peroxisomal Localization of a Truncated HMG-CoA Reductase under Low Cholesterol Conditions.
Wang J, Kunze M, Villoria-González A, Weinhofer I, Berger J., Free PMC Article | 02/28/2024 |
| Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease. | Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease.
Li Y, Li J, Tang X, Xu J, Liu R, Jiang L, Tian J, Zhang Y, Wang D, Sun K, Xu B, Zhao W, Hui R, Gao R, Song L, Yuan J, Zhao X., Free PMC Article | 01/30/2024 |
| Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1. | Early growth response 1 promoted the invasion of glioblastoma multiforme by elevating HMGB1.
DU K, Wu X, Ji X, Liang N, Li Z. | 01/30/2024 |
| Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents. | Association between HMGCR, CRP, and CETP gene polymorphisms and metabolic/inflammatory serum profile in healthy adolescents.
Perrone B, Ruffo P, Augimeri G, Sisci D, Sinicropi MS, Tripepi G, Mammì C, Bonofiglio D, Conforti FL., Free PMC Article | 10/24/2023 |
| HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins. | HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins.
Li J, Tang X, Xu J, Liu R, Jiang L, Xu L, Tian J, Feng X, Wu Y, Zhang Y, Wang D, Sun K, Xu B, Zhao W, Hui R, Gao R, Song L, Yuan J, Zhao X., Free PMC Article | 06/26/2023 |
| Effect of pH on structural dynamics of HMG-CoA reductase and binding affinity to beta-sitosterol. | Effect of pH on structural dynamics of HMG-CoA reductase and binding affinity to β-sitosterol.
Fatoki TH. | 06/15/2023 |
| Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone. | Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone.
Yogev Y, Shorer Z, Koifman A, Wormser O, Drabkin M, Halperin D, Dolgin V, Proskorovski-Ohayon R, Hadar N, Davidov G, Nudelman H, Zarivach R, Shelef I, Perez Y, Birk OS., Free PMC Article | 02/28/2023 |
| Novel polymorphism of the HMGCR gene related to the risk of diabetes in premature triple-vessel disease patients. | Novel polymorphism of the HMGCR gene related to the risk of diabetes in premature triple-vessel disease patients.
Zhao X, Tang X, Xu J, Liu R, Huang K, Li J, Li Y, Jiang L, Xu L, Zhang Y, Wang D, Hui R, Gao R, Song L, Yuan J. | 10/8/2022 |
| High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis. | High-Risk Polymorphisms Associated with the Molecular Function of Human HMGCR Gene Infer the Inhibition of Cholesterol Biosynthesis.
Das KC, Hossain MU, Moniruzzaman M, Salimullah M, Akhteruzzaman S., Free PMC Article | 06/25/2022 |
| Mitochondrial dysfunction in anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune-mediated necrotising myopathy. | Mitochondrial dysfunction in anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) immune-mediated necrotising myopathy.
Acosta IJ, Hofer M, Brady S. | 06/11/2022 |
| Association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene polymorphism with obesity and lipid metabolism in children and adolescents with autism spectrum disorder. | Association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene polymorphism with obesity and lipid metabolism in children and adolescents with autism spectrum disorder.
Kwon SJ, Hong KW, Choi S, Hong JS, Kim JW, Kim JW, Lee HJ, Jang HB, Yum KS. | 04/16/2022 |
| Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies: incidence using different testing criteria, and case series. | Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies: incidence using different testing criteria, and case series.
Joseph VMK, Rose EC, Edwards CJ, Lloyd M, Amar SK, Wheeler RD, Forster T, Smith KA, Eren E, Hughes R, Hajela V, Kiely PDW. | 03/5/2022 |
| Association of NPC1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel Disease. | Association of NPC1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel Disease.
Zhao X, Li J, Tang X, Liu R, Xu J, Xu L, Jiang L, Huang K, Tian J, Feng X, Wu Y, Zhang Y, Wang D, Sun K, Xu B, Zhao W, Hui R, Gao R, Song L, Yuan J. | 02/5/2022 |
| A Possible Role for HMG-CoA Reductase Inhibitors and Its Association with HMGCR Genetic Variation in Parkinson's Disease. | A Possible Role for HMG-CoA Reductase Inhibitors and Its Association with HMGCR Genetic Variation in Parkinson's Disease.
Pierzchlińska A, Droździk M, Białecka M., Free PMC Article | 12/18/2021 |
| Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-beta-treated epithelial cancer cells. | Concomitant attenuation of HMGCR expression and activity enhances the growth inhibitory effect of atorvastatin on TGF-β-treated epithelial cancer cells.
Warita K, Ishikawa T, Sugiura A, Tashiro J, Shimakura H, Hosaka YZ, Ohta KI, Warita T, Oltvai ZN., Free PMC Article | 10/30/2021 |
| A-family anti-inflammatory cyclopentenone prostaglandins: A novel class of non-statin inhibitors of HMG-CoA reductase. | A-family anti-inflammatory cyclopentenone prostaglandins: A novel class of non-statin inhibitors of HMG-CoA reductase.
Gutierrez LLP, Marques CV, Scomazzon SP, Schroeder HT, Fernandes JR, da Silva Rossato J, Homem de Bittencourt PI Jr. | 06/12/2021 |
| Mesenchymal subtype neuroblastomas are addicted to TGF-betaR2/HMGCR-driven protein geranylgeranylation. | Mesenchymal subtype neuroblastomas are addicted to TGF-βR2/HMGCR-driven protein geranylgeranylation.
Stokes ME, Small JC, Vasciaveo A, Shimada K, Hirschhorn T, Califano A, Stockwell BR., Free PMC Article | 01/9/2021 |
| The Polymorphism rs2968 of LSS Gene Confers Susceptibility to Age-Related Cataract. | The Polymorphism rs2968 of LSS Gene Confers Susceptibility to Age-Related Cataract.
Zou X, Wang H, Zhou D, Liu Z, Wang Y, Deng G, Guan H. | 11/28/2020 |
| Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations. | Anti-HMGCR Antibody-Positive Myopathy Shows Bcl-2-Positive Inflammation and Lymphocytic Accumulations.
Kurashige T, Murao T, Mine N, Sugiura T, Inazuka Y, Kuraoka K, Takahashi T, Maruyama H, Torii T., Free PMC Article | 11/21/2020 |
| In this study, it's demonstrated that doxorubicin exerts its anti-cancer effect via modulation of cholesterol synthesis through downregulation of HMG-CoA reductase (HMG-CR) expression, which is mediated by the epidermal growth factor receptor(EGFR)-Src pathway. | Anti-cancer effect of doxorubicin is mediated by downregulation of HMG-Co A reductase via inhibition of EGFR/Src pathway.
Yun UJ, Lee JH, Shim J, Yoon K, Goh SH, Yi EH, Ye SK, Lee JS, Lee H, Park J, Lee IH, Kim YN. | 06/27/2020 |
| lanosterol is a bona fide endogenous regulator that specifically promotes HMGCR degradation, and that other C4-dimethylated sterol intermediates may regulate both HMGCR degradation and SREBP-2 cleavage | Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing.
Chen L, Ma MY, Sun M, Jiang LY, Zhao XT, Fang XX, Man Lam S, Shui GH, Luo J, Shi XJ, Song BL., Free PMC Article | 06/27/2020 |
| rs3846662:C>A HMGCR affect the blood apoB levels which might be predictive of cardiovascular disease risk. [Meta- analysis] | A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels.
Rosticci M, Pervjakova N, Kaakinen M, Cicero AF, Feufer AP, Marullo L, Mägi R, Fischer K, Jiang L, D'Addato S, Rizzoli E, Massimo G, Giovannini M, Angelini S, Hrelia P, Scapoli C, Borghi C, Prokopenko I. | 06/13/2020 |
| Statin treatment led to an upregulation of HMGCR mRNA and protein expression by up to sixfolds in the statin-resistant cells lines (p < 0.001), but no alterations of HMGCR were observed in the statin-sensitive MDA-MB-231 and MDA-MB-468 cells. The knockdown of HMGCR prior to statin treatment sensitized the resistant cell lines. | Induction of 3-hydroxy-3-methylglutaryl-CoA reductase mediates statin resistance in breast cancer cells.
Göbel A, Breining D, Rauner M, Hofbauer LC, Rachner TD., Free PMC Article | 04/25/2020 |
| Genetically proxied inhibition of HMG-CoA reductase was significantly associated with lower odds of epithelial ovarian cancer. | Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer.
Yarmolinsky J, Bull CJ, Vincent EE, Robinson J, Walther A, Smith GD, Lewis SJ, Relton CL, Martin RM., Free PMC Article | 03/7/2020 |