| results uncover a significant but hitherto uncharacterized involvement of IRM components Hbs, Kirre, and specially Rst in ovarian development | Expression of Hbs, Kirre, and Rst during Drosophila ovarian development.
Valer FB, Machado MCR, Silva-Junior RMP, Ramos RGP. | 01/19/2019 |
| the roles of Rst, Hbs, Kirre and SNS in the spacing of bristles of the anterior wing margin, are explored. | The Cell Adhesion Molecules Roughest, Hibris, Kin of Irre and Sticks and Stones Are Required for Long Range Spacing of the Drosophila Wing Disc Sensory Sensilla.
Linneweber GA, Winking M, Fischbach KF., Free PMC Article | 03/5/2016 |
| removing Kirre protein specifically disrupts the functional L4 synaptic network in the Drosophila lamina. | The irre cell recognition module (IRM) protein Kirre is required to form the reciprocal synaptic network of L4 neurons in the Drosophila lamina.
Lüthy K, Ahrens B, Rawal S, Lu Z, Tarnogorska D, Meinertzhagen IA, Fischbach KF. | 07/4/2015 |
| Dumbfounded/Neph1, a key diaphragm constituent, is a target of the Src kinase Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 tyrosine phosphorylation. | Src64B phosphorylates Dumbfounded and regulates slit diaphragm dynamics: Drosophila as a model to study nephropathies.
Tutor AS, Prieto-Sánchez S, Ruiz-Gómez M. | 03/1/2014 |
| Analysis of a cytoplasmic motif present in Kirre and IrreC/Rst revealed a functionally required, conserved 12 AA motif (KIN1 motif). | Functional study of mammalian Neph proteins in Drosophila melanogaster.
Helmstädter M, Lüthy K, Gödel M, Simons M, Ashish, Nihalani D, Rensing SA, Fischbach KF, Huber TB., Free PMC Article | 04/6/2013 |
| Dumbfounded and Sticks and Stones are expressed in the genital imaginal disc and in the muscle sheath of the testes during muscle differentiation. | Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster.
Susic-Jung L, Hornbruch-Freitag C, Kuckwa J, Rexer KH, Lammel U, Renkawitz-Pohl R. | 11/17/2012 |
| Findings suggest a general mechanism by which rst and kirre expression could be fine tuned to optimize their redundant roles during development. | rst transcriptional activity influences kirre mRNA concentration in the Drosophila pupal retina during the final steps of ommatidial patterning.
Machado MC, Octacilio-Silva S, Costa MS, Ramos RG., Free PMC Article | 02/18/2012 |
| Results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf. | The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
Bulchand S, Menon SD, George SE, Chia W., Free PMC Article | 10/4/2010 |
| analysis of the spatio-temporal regulation of the Drosophila myoblast attractant gene duf/kirre | The complex spatio-temporal regulation of the Drosophila myoblast attractant gene duf/kirre.
Guruharsha KG, Ruiz-Gomez M, Ranganath HA, Siddharthan R, Vijayraghavan K., Free PMC Article | 02/8/2010 |
| Kirre and Sns are co-expressed within binucleate garland cell nephrocytes that contribute to detoxification of hemolymph by uptake of molecules through a slit diaphragm-like nephrocyte diaphragm into labyrinthine channels that are sites of endocytosis. | Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes.
Zhuang S, Shao H, Guo F, Trimble R, Pearce E, Abmayr SM., Free PMC Article | 01/21/2010 |
| Duf is a type 1 transmembrane protein that induces Rols7 translocation specifically when present intact and engaged in homophilic or Duf-SNS adhesion. | A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila.
Menon SD, Osman Z, Chenchill K, Chia W., Free PMC Article | 01/21/2010 |