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    HLA-C major histocompatibility complex, class I, C [ Homo sapiens (human) ]

    Gene ID: 3107, updated on 28-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of the Genetic Diversity of Killer Cell Immunoglobulin-like Receptor Genes and HLA-C Ligand in Saudi Women With Thyroid Cancer.

    Association of the Genetic Diversity of Killer Cell Immunoglobulin-like Receptor Genes and HLA-C Ligand in Saudi Women With Thyroid Cancer.
    Altalhi RA, Aljuaimlani A, Alswayyed M, Arafah M, Tashkandy Y, Almutairi BO, Mansour L, Alomar SY., Free PMC Article

    10/10/2024
    HLA-Cw6 Polymorphism in Autoimmune Blistering Diseases.

    HLA-Cw6 Polymorphism in Autoimmune Blistering Diseases.
    Ciolfi C, Sernicola A, Alaibac M., Free PMC Article

    10/8/2024
    Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C.

    Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C.
    Mikaeeli S, Ben Djoudi Ouadda A, Evagelidis A, Essalmani R, Ramos OHP, Fruchart-Gaillard C, Seidah NG., Free PMC Article

    09/10/2024
    Impact of HLA Class I Antigen, Killer Inhibitory Receptor, and FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor Stage.

    Impact of HLA Class I Antigen, Killer Inhibitory Receptor, and FCGR3A Genotypes on Breast Cancer Susceptibility and Tumor Stage.
    Canossi A, Aureli A, Del Beato T, Novelli G, Buonomo O, Rossi P, Venditti A, Papola F, Sconocchia G.

    07/18/2024
    The protective association of HLA-C*12:02 and HLA-DQB1*06:01 with severe acute hepatitis of unknown origin in the Japanese population.

    The protective association of HLA-C*12:02 and HLA-DQB1*06:01 with severe acute hepatitis of unknown origin in the Japanese population.
    Okamoto T, Okajima H, Ogawa E, Kadohisa M, Yamamoto M, Uebayashi EY, Yurugi K, Ito T, Hatano E.

    07/3/2024
    [Genetic study of a rare Chinese pedigree with a recombination occurring between the HLA-A/C loci in both parents].

    [Genetic study of a rare Chinese pedigree with a recombination occurring between the HLA-A/C loci in both parents].
    Wang T, Wang M, Qi J, Li Y, Wu J, Shang L, Chen L.

    07/2/2024
    Establishing association between HLA-C*04:01 and severe COVID-19.

    Establishing association between HLA-C*04:01 and severe COVID-19.
    Warren RL, Abraham R, Calingo M, Garant JM, Jones SJM, Birol I, CGEn HostSeq Initiative.

    06/21/2024
    HLA-B and C Expression Contributes to COVID-19 Disease Severity within a South African Cohort.

    HLA-B and C Expression Contributes to COVID-19 Disease Severity within a South African Cohort.
    Naidoo L, Arumugam T, Ramsuran V., Free PMC Article

    05/16/2024
    HLA-G isoforms, HLA-C allotype and their expressions differ between early abortus and placenta in relation to spontaneous abortions.

    HLA-G isoforms, HLA-C allotype and their expressions differ between early abortus and placenta in relation to spontaneous abortions.
    Bora M, Singha S, Madan T, Deka G, Hazarika SG, Baruah S.

    04/12/2024
    Helicobacter pylori enhances HLA-C expression in the human gastric adenocarcinoma cells AGS and can protect them from the cytotoxicity of natural killer cells.

    Helicobacter pylori enhances HLA-C expression in the human gastric adenocarcinoma cells AGS and can protect them from the cytotoxicity of natural killer cells.
    Apoorva E, Jacob R, Rao DN, Kumar S.

    04/4/2024
    HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation.

    HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation.
    Welters C, Welters ML, Stadler S, Bullinger L, Strobel J, Hackstein H, Dhamodaran A, Blankenstein T, Hansmann L., Free PMC Article

    04/4/2024
    The protective association of HLA-B *52:01, HLA-C *12:02, and DQB1 *06:01 alleles with severe acute hepatitis of unknown origin in Japanese children.

    The protective association of HLA-B∗52:01, HLA-C∗12:02, and DQB1∗06:01 alleles with severe acute hepatitis of unknown origin in Japanese children.
    Okamoto T, Okajima H, Ogawa E, Yurugi K, Hatano E.

    03/1/2024
    HLA-C*07:01 and HLA-DQB1*02:01 protect against white matter hyperintensities and deterioration of cognitive function: A population-based cohort study.

    HLA-C*07:01 and HLA-DQB1*02:01 protect against white matter hyperintensities and deterioration of cognitive function: A population-based cohort study.
    Gao Y, Su B, Luo Y, Tian Y, Hong S, Gao S, Xie J, Zheng X.

    01/3/2024
    HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp.

    HLA-C*15:02 and epidermal growth factor receptor inhibitor-induced erosive pustular dermatosis of the scalp.
    Zhang Y, Grice S, Wang N, Liu Y, Zhao Q, Liu T, Sun L, Mi Z, Wang J, Yu G, Zhang F, Meng X, Liu H, Naisbitt DJ, Sun Y, Zhang F.

    10/30/2023
    Associations of HLA-C*01:02 and HLA-B*46:01 with regorafenib-induced erythema multiforme in Japanese patients with metastatic colorectal cancer.

    Associations of HLA-C*01:02 and HLA-B*46:01 with regorafenib-induced erythema multiforme in Japanese patients with metastatic colorectal cancer.
    Fujita KI, Matsumoto N, Murase R, Takeshima K, Ishida H, Kubota Y., Free PMC Article

    10/24/2023
    Frequency changes in HLA-I alleles: A marker to guide immunotherapy in lung adenocarcinoma patients and its relationship with tumor mutational burden and PD-L1 expression.

    Frequency changes in HLA-I alleles: A marker to guide immunotherapy in lung adenocarcinoma patients and its relationship with tumor mutational burden and PD-L1 expression.
    Wu X, Wang H, Xue F, Jiang T, Chen N, Wang T, Zhang Y, Zhang G, Fu J, Wu Q., Free PMC Article

    09/6/2023
    Genetic Influence on Treatment Response in Psoriasis: New Insights into Personalized Medicine.

    Genetic Influence on Treatment Response in Psoriasis: New Insights into Personalized Medicine.
    Berna-Rico E, Perez-Bootello J, Abbad-Jaime de Aragon C, Gonzalez-Cantero A., Free PMC Article

    08/28/2023
    Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population.

    Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population.
    Zhang Q, Shi P, Wang Z, Sun L, Li W, Zhao Q, Liu T, Pan Q, Sun Y, Jia F, Chen W, Fu X, Yu G, Bao F, Mi Z, Wang C, Sun Y, Li B, Liu J, Liu H, Gu H, Zhang F.

    07/25/2023
    A novel HLA-C*06 allele, HLA-C*06:02:96, identified by next-generation sequencing in a Chinese family.

    A novel HLA-C*06 allele, HLA-C*06:02:96, identified by next-generation sequencing in a Chinese family.
    Wang X, Wang J, Zhang Y, Yao Y.

    06/21/2023
    The HLA-Cw*06 allele may predict the response to methotrexate (MTX) treatment in Chinese arthritis-free psoriasis patients.

    The HLA-Cw*06 allele may predict the response to methotrexate (MTX) treatment in Chinese arthritis-free psoriasis patients.
    Mao M, Kuang Y, Chen M, Yan K, Lv C, Liu P, Lu Y, Chen X, Zhu W, Chen W.

    05/25/2023
    The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C *07 Expression in Patients with Endometriosis.

    The Association between Deoxyribonucleic Acid Hypermethylation in Intron VII and Human Leukocyte Antigen-C∗07 Expression in Patients with Endometriosis.
    Zhao W, Lei L, Chen R, Zhang Y, Chang L, Cheng J., Free PMC Article

    04/5/2023
    Association of HLA-C*01:02 with methazolamide-induced toxic epidermal necrolysis.

    Association of HLA-C*01:02 with methazolamide-induced toxic epidermal necrolysis.
    Qiumei G, Zhengju C, Xuefei H, Qu C.,

    03/3/2023
    Differential HLA class I subunit (A, B, C heavy chain and beta2-microglobulin) expression levels in normal tissues.

    Differential HLA class I subunit (A, B, C heavy chain and β(2)-microglobulin) expression levels in normal tissues.
    Ugolini F, Szumera-Ciećkiewicz A, Baroni G, Nesi G, Mandalà M, Ferrone S, Massi D., Free PMC Article

    02/18/2023
    HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes.

    HLA variants have different preferences to present proteins with specific molecular functions which are complemented in frequent haplotypes.
    Karnaukhov V, Paes W, Woodhouse IB, Partridge T, Nicastri A, Brackenridge S, Shcherbinin D, Chudakov DM, Zvyagin IV, Ternette N, Koohy H, Borrow P, Shugay M., Free PMC Article

    01/14/2023
    Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.

    Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.
    Vollmers S, Lobermeyer A, Niehrs A, Fittje P, Indenbirken D, Nakel J, Virdi S, Brias S, Trenkner T, Sauer G, Peine S, Behrens GMN, Lehmann C, Meurer A, Pauli R, Postel N, Roider J, Scholten S, Spinner CD, Stephan C, Wolf E, Wyen C, Richert L, Norman PJ, Sauter J, Schmidt AH, Hoelzemer A, Altfeld M, Körner C., Free PMC Article

    10/22/2022
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