| miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis. | miRNA Expression Profiles of Mouse Round Spermatids in GRTH/DDX25-Mediated Spermiogenesis: mRNA-miRNA Network Analysis.
Anbazhagan R, Kavarthapu R, Dale R, Campbell K, Faucz FR, Dufau ML., Free PMC Article | 03/14/2023 |
| Single-Cell Transcriptomic Profiling of the Mouse Testicular Germ Cells Reveals Important Role of Phosphorylated GRTH/DDX25 in Round Spermatid Differentiation and Acrosome Biogenesis during Spermiogenesis. | Single-Cell Transcriptomic Profiling of the Mouse Testicular Germ Cells Reveals Important Role of Phosphorylated GRTH/DDX25 in Round Spermatid Differentiation and Acrosome Biogenesis during Spermiogenesis.
Kavarthapu R, Anbazhagan R, Pal S, Dufau ML., Free PMC Article | 02/28/2023 |
| Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis. | Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis.
Kavarthapu R, Anbazhagan R, Raju M, Morris CT, Pickel J, Dufau ML., Free PMC Article | 09/4/2021 |
| The association of Tp2 expression via binding to the conserved RNA binding motifs of GRTH protein and the basis for understanding GRTH in the regulation of the genes essential for germ cell elongation and completion of spermatogenesis is revealed. | Elucidation of RNA binding regions of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) to transcripts of a chromatin remodeling protein essential for spermatogenesis.
Yang R, Tsai-Morris CH, Kang JH, Dufau ML. | 02/6/2016 |
| Data indicate that the transgenic line can be used to define requirements for cell-specific expression of the RNA helicase (GRTH/DDX25) gene. | A 5'-flanking region of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene directs its cell-specific androgen-regulated gene expression in testicular germ cells.
Kavarthapu R, Tsai-Morris CH, Fukushima M, Pickel J, Dufau ML., Free PMC Article | 07/27/2013 |
| The results suggest that DDX25 functions in meiotic cells,intermitochondrial cement,loose aggregates of particles,chromatoid bodies,late chromatoid bodies,satellite bodies,granulated bodies,mitochondria-associated granules and reticulated bodies. | Expression of DDX25 in nuage components of mammalian spermatogenic cells: immunofluorescence and immunoelectron microscopic study.
Onohara Y, Yokota S. | 09/22/2012 |
| Data show the regulatory pathways underlying GRTH action in male reproduction. | Role of gonadotropin regulated testicular RNA helicase (GRTH/Ddx25) on polysomal associated mRNAs in mouse testis.
Tsai-Morris CH, Sato H, Gutti R, Dufau ML., Free PMC Article | 09/1/2012 |
| GRTH regulation by androgen in Leydig cells; molecular mechanism of androgen-regulated transcription | Androgen-induced activation of gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) transcription: essential role of a nonclassical androgen response element half-site.
Villar J, Tsai-Morris CH, Dai L, Dufau ML., Free PMC Article | 06/30/2012 |
| Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development. | Testis-specific miRNA-469 up-regulated in gonadotropin-regulated testicular RNA helicase (GRTH/DDX25)-null mice silences transition protein 2 and protamine 2 messages at sites within coding region: implications of its role in germ cell development.
Dai L, Tsai-Morris CH, Sato H, Villar J, Kang JH, Zhang J, Dufau ML., Free PMC Article | 03/3/2012 |
| Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells: central role of steroidogenic acute regulatory protein (StAR). | Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25), a negative regulator of luteinizing/chorionic gonadotropin hormone-induced steroidogenesis in Leydig cells: central role of steroidogenic acute regulatory protein (StAR).
Fukushima M, Villar J, Tsai-Morris CH, Dufau ML., Free PMC Article | 10/22/2011 |
| GRTH, as a component of mRNP particles, acts as a negative regulator of the tumor necrosis factor receptor 1 and caspase pathways and promotes NF-kappaB function to control apoptosis in spermatocytes of adult mice | Gonadotropin-regulated testicular helicase (DDX25), an essential regulator of spermatogenesis, prevents testicular germ cell apoptosis.
Gutti RK, Tsai-Morris CH, Dufau ML., Free PMC Article | 01/21/2010 |
| demonstrates that GRTH is essential for completion of spermatogenesis, (ii) provides insights into intrinsic requirements for spermiogenesis, and (iii) establishes a model for studies of male infertility and contraception | Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is essential for spermatid development and completion of spermatogenesis.
Tsai-Morris CH, Sheng Y, Lee E, Lei KJ, Dufau ML., Free PMC Article | 01/21/2010 |