| The aging mouse lens transcriptome. | The aging mouse lens transcriptome.
Faranda AP, Shihan MH, Wang Y, Duncan MK., Free PMC Article | 12/4/2021 |
| These results clearly show that the development of early-onset cataracts requires at least two mutant alleles of Foxe3(rct) and Pde6b(rd1), and another modifier associated with the severity of cataract phenotypes in Foxe3(rct) mice underlies the genetic backgrounds in mice. | Pde6b(rd1) mutation modifies cataractogenesis in Foxe3(rct) mice.
Wada K, Saito J, Yamaguchi M, Seki Y, Furugori M, Takahashi G, Nishito Y, Matsuda H, Shitara H, Kikkawa Y. | 02/17/2018 |
| The Hedgehog pathway with its member Smoothened is required during a discrete embryonic period (E9.5-E12.5) in lens development to regulate lens epithelial cell proliferation, survival and FoxE3 expression. | A role for smoothened during murine lens and cornea development.
Choi JJ, Ting CT, Trogrlic L, Milevski SV, Familari M, Martinez G, de Iongh RU., Free PMC Article | 06/20/2015 |
| Foxe3 as a transcriptional target of Pitx3 explains at least in part some of the phenotypic similarities of the ak and dyl mice (dysgenic lens, a Foxe3 allele). | Pitx3 directly regulates Foxe3 during early lens development.
Ahmad N, Aslam M, Muenster D, Horsch M, Khan MA, Carlsson P, Beckers J, Graw J. | 09/6/2014 |
| The observed changes in the expression of FoxE3 suggest that Msx2 is an important contributor in controlling transcription of target genes critical for early eye development. | Loss of Msx2 function down-regulates the FoxE3 expression and results in anterior segment dysgenesis resembling Peters anomaly.
Zhao J, Kawai K, Wang H, Wu D, Wang M, Yue Z, Zhang J, Liu YH., Free PMC Article | 09/1/2012 |
| the ectopic activation of downstream effectors of the hedgehog signaling pathway in the mouse lens disrupts normal fiber cell differentiation by a mechanism consistent with a sustained epithelial cellular developmental program driven by FoxE3. | Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.
Kerr CL, Huang J, Williams T, West-Mays JA., Free PMC Article | 08/18/2012 |
| cataracts in rct mice are caused by reduced Foxe3 expression in the lens and this decreased expression is a result of a deletion in a cis-acting regulatory element | A deletion in a cis element of Foxe3 causes cataracts and microphthalmia in rct mice.
Wada K, Maeda YY, Watanabe K, Oshio T, Ueda T, Takahashi G, Yokohama M, Saito J, Seki Y, Takahama S, Ishii R, Shitara H, Taya C, Yonekawa H, Kikkawa Y. | 04/7/2012 |
| Data found no evidence that Pitx3 and Foxe3 genetically interact. | Pitx3 controls multiple aspects of lens development.
Medina-Martinez O, Shah R, Jamrich M., Free PMC Article | 01/21/2010 |
| Proper inactivation of FoxE3 expression at the lens equator is important for many aspects of fiber differentiation, and persistent expression leads to a partial epithelialization of fiber cells, with severe consequences for lens function. | Persistent FoxE3 expression blocks cytoskeletal remodeling and organelle degradation during lens fiber differentiation.
Landgren H, Blixt A, Carlsson P. | 01/21/2010 |
| early Foxe3 expression is sensitive to halved Pax6 gene dosage & there is phenotypic similarity between Pax6 & Foxe3 mutants; we propose that many ocular malformations associated with Pax6 haploinsufficiency are consequences of reduced Foxe3 expression | Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage.
Blixt A, Landgren H, Johansson BR, Carlsson P. | 01/21/2010 |
| Foxe3 promoter was activated by Sip1 | Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation.
Yoshimoto A, Saigou Y, Higashi Y, Kondoh H. | 01/21/2010 |
| targeted disruption of Foxe3 results in abnormal development of the eye. Cells of the anterior lens epithelium show a decreased rate of proliferation, resulting in a smaller than normal lens. | Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice.
Medina-Martinez O, Brownell I, Amaya-Manzanares F, Hu Q, Behringer RR, Jamrich M., Free PMC Article | 01/21/2010 |