| Data provide evidence that EHD3 might undergo its tumor suppressor functions at least in part through promoting the sorting of activated EGFR to the lysosomal degradative compartment and spatio-temporal regulation of EGFR signaling via ERK and AKT. | Spatio-temporal regulation of EGFR signaling by the Eps15 homology domain-containing protein 3 (EHD3).
Amessou M, Ebrahim AS, Dilly A, Joseph M, Tabolina M, Chukkapalli S, Meroueh L, Syed JT, Liddane A, Lang SL, Al-Katib A, Kandouz M., Free PMC Article | 02/17/2018 |
| the residues Ala-519/Asp-520 of EHD1 and Asn-519/Glu-520 of EHD3 as defining the selectivity of these two paralogs for NPF-containing binding partners | EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.
Bahl K, Xie S, Spagnol G, Sorgen P, Naslavsky N, Caplan S., Free PMC Article | 11/12/2016 |
| The EHD3 gene may be associated with the endophenotype of cognitive function in major depressive disorder patients. | Association between EHD3 gene and the cognitive function of patients with major depressive disorder.
Wang L, Shi CJ, Xu Q. | 02/28/2015 |
| 3 SNPs present in the EHD3 gene, of which rs619002 and rs644926 were exclusively associated with female major depressive disorder | The gender-specific association of EHD3 polymorphisms with major depressive disorder.
Wang L, Shi C, Zhang K, Xu Q. | 11/22/2014 |
| demonstrate Ehd3 growth inhibitory functions in glioma cells in vivo. We suggest that Ehd3 functions as a tumor suppressor gene and loss of its expression is a very common event in gliomas | Ehd3, a regulator of vesicular trafficking, is silenced in gliomas and functions as a tumor suppressor by controlling cell cycle arrest and apoptosis.
Chukkapalli S, Amessou M, Dekhil H, Dilly AK, Liu Q, Bandyopadhyay S, Thomas RD, Bejna A, Batist G, Kandouz M. | 05/31/2014 |
| evidence that the functions of both EHD1 and EHD4 are primarily in TRE membrane vesiculation, whereas EHD3 is a membrane-tubulating protein. | Differential roles of C-terminal Eps15 homology domain proteins as vesiculators and tubulators of recycling endosomes.
Cai B, Giridharan SSP, Zhang J, Saxena S, Bahl K, Schmidt JA, Sorgen PL, Guo W, Naslavsky N, Caplan S., Free PMC Article | 01/4/2014 |
| The combined effect of the EHD3 and FREM3 genes may play an important role in developing major depressive disorder. | A study of the combined effects of the EHD3 and FREM3 genes in patients with major depressive disorder.
Shi C, Zhang K, Wang X, Shen Y, Xu Q. | 10/6/2012 |
| EHD3 is a previously unrecognized component of the cardiac remodeling pathway in heart failure. | Differential regulation of EHD3 in human and mammalian heart failure.
Gudmundsson H, Curran J, Kashef F, Snyder JS, Smith SA, Vargas-Pinto P, Bonilla IM, Weiss RM, Anderson ME, Binkley P, Felder RB, Carnes CA, Band H, Hund TJ, Mohler PJ., Free PMC Article | 08/11/2012 |
| A new class of cardiac trafficking proteins(EHD1, EHD2, EHD3, EHD4) regulates cardiac membrane protein targeting. | EH domain proteins regulate cardiac membrane protein targeting.
Gudmundsson H, Hund TJ, Wright PJ, Kline CF, Snyder JS, Qian L, Koval OM, Cunha SR, George M, Rainey MA, Kashef FE, Dun W, Boyden PA, Anderson ME, Band H, Mohler PJ., Free PMC Article | 09/6/2010 |
| Our findings support a role for EHD3 in regulating endosome-to-Golgi transport, and as a consequence, lysosomal biosynthetic, but not secretory, transport pathways are also affected | EHD3 regulates early-endosome-to-Golgi transport and preserves Golgi morphology.
Naslavsky N, McKenzie J, Altan-Bonnet N, Sheff D, Caplan S., Free PMC Article | 01/21/2010 |
| Rab8a and Myosin Vb colocalize to a tubular network containing EHD1 and EHD3, which does not contain Rab11a. | Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3.
Roland JT, Kenworthy AK, Peranen J, Caplan S, Goldenring JR., Free PMC Article | 01/21/2010 |
| EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1. | EHD3: a protein that resides in recycling tubular and vesicular membrane structures and interacts with EHD1.
Galperin E, Benjamin S, Rapaport D, Rotem-Yehudar R, Tolchinsky S, Horowitz M. | 01/21/2010 |
| presented herein promote a coordinated role for EHD proteins and Rab11-FIP2 in mediating endocytic recycling and provide evidence for the function of EHD3 in early endosome to endocytic recycling compartment transport | Interactions between EHD proteins and Rab11-FIP2: a role for EHD3 in early endosomal transport.
Naslavsky N, Rahajeng J, Sharma M, Jovic M, Caplan S., Free PMC Article | 01/21/2010 |