| miR-4270 suppresses hepatocellular carcinoma progression by inhibiting DNMT3A-mediated methylation of HGFAC promoter. | miR-4270 suppresses hepatocellular carcinoma progression by inhibiting DNMT3A-mediated methylation of HGFAC promoter.
Zou Q, Cao S., Free PMC Article | 12/18/2023 |
| Role of hypoxia on microRNA-dependant regulation of HGFA - HGF - c-Met signalling pathway in human progenitor and mature endothelial cells. | Role of hypoxia on microRNA-dependant regulation of HGFA - HGF - c-Met signalling pathway in human progenitor and mature endothelial cells.
Tokarski M, Cierzniak A, Baczynska D. | 11/13/2023 |
| HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. | HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis.
Sargsyan A, Doridot L, Hannou SA, Tong W, Srinivasan H, Ivison R, Monn R, Kou HH, Haldeman JM, Arlotto M, White PJ, Grimsrud PA, Astapova I, Tsai LT, Herman MA., Free PMC Article | 01/14/2023 |
| Hypermethylation around the promoter region contributed to the decreased expression of HGFAC. HGFAC may be a useful and predictive biomarker for the prognosis of liver cancer patients. | HGFAC expression decreased in liver cancer and its low expression correlated with DNA hypermethylation and poor prognosis.
Yin L, Mu Y, Lin Y, Xia Q. | 07/18/2020 |
| Based upon ethnicity-stratified single-variant association analysis and trans-ethnic meta-analysis of 6201 participants of the Multi-Ethnic Study of Atherosclerosis, discovered 5 common and low-frequency variants: HGF missense polymorphism rs5745687 (p.E299K) and 4 variants (rs16844364, rs4690098, rs114303452, rs3748034) within or in proximity to HGFAC.[Meta-analysis] | Trans-ethnic meta-analysis identifies common and rare variants associated with hepatocyte growth factor levels in the Multi-Ethnic Study of Atherosclerosis (MESA).
Larson NB, Berardi C, Decker PA, Wassel CL, Kirsch PS, Pankow JS, Sale MM, de Andrade M, Sicotte H, Tang W, Hanson NQ, Tsai MY, Taylor KD, Bielinski SJ., Free PMC Article | 09/5/2015 |
| Observational study of gene-disease association. (HuGE Navigator) | L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T. | 06/30/2010 |
| Results suggest that hepatocyte growth factor activator is a major serum activator of pro-macrophage-stimulating protein. | Hepatocyte growth factor activator is a serum activator of single-chain precursor macrophage-stimulating protein.
Kawaguchi M, Orikawa H, Baba T, Fukushima T, Kataoka H. | 01/21/2010 |
| the activated form of HGFA is present at high levels in serum and bone marrow of myeloma patients, thus providing a necessary prerequisite for the activation of HGF. | Elevated serum concentrations of activated hepatocyte growth factor activator in patients with multiple myeloma.
Wader KF, Fagerli UM, Holt RU, Stordal B, Børset M, Sundan A, Waage A., Free PMC Article | 01/21/2010 |
| Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. | Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer.
Kitajima Y, Ide T, Ohtsuka T, Miyazaki K., Free PMC Article | 01/21/2010 |
| KLK4 and KLK5 activate pro-HGFA. | Activation of hepatocyte growth factor activator zymogen (pro-HGFA) by human kallikrein 1-related peptidases.
Mukai S, Fukushima T, Naka D, Tanaka H, Osada Y, Kataoka H. | 01/21/2010 |
| HGF/MET signaling and aberrant HGF-activator expression is associated with diffuse large B-cell lymphoma | Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma.
Tjin EP, Groen RW, Vogelzang I, Derksen PW, Klok MD, Meijer HP, van Eeden S, Pals ST, Spaargaren M. | 01/21/2010 |
| the HGF-activator has a role in multiple myeloma cells' catalysis of hepatocyte growth factor (HGF) activation | Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator.
Tjin EP, Derksen PW, Kataoka H, Spaargaren M, Pals ST. | 01/21/2010 |
| HAI-1 (serine peptidase inhibitor, Kunitz type 1) specifically traps active form of HGF activator on cellular surface and regulates HGF activation in pericellular microenvironment. | Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment.
Kataoka H, Shimomura T, Kawaguchi T, Hamasuna R, Itoh H, Kitamura N, Miyazawa K, Koono M. | 09/23/2005 |