| Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia. | Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia.
Zhang D, Wu X, Xue X, Li W, Zhou P, Lv Z, Zhao K, Zhu F., Free PMC Article | 02/21/2024 |
| ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia. | ERVW-1 Activates ATF6-Mediated Unfolded Protein Response by Decreasing GANAB in Recent-Onset Schizophrenia.
Xue X, Wu X, Liu L, Liu L, Zhu F., Free PMC Article | 07/7/2023 |
| Serum circulating free DNA of syncytin-1 as a novel molecular marker for early diagnosis of non-small-cell lung cancer. | Serum circulating free DNA of syncytin-1 as a novel molecular marker for early diagnosis of non-small-cell lung cancer.
Zhuang X, Qian J, Xia X, Wang Y, Wang H, Jing L, Zhang Y, Zhang Y. | 03/27/2023 |
| Interaction between Long Noncoding RNAs and Syncytin-1/Syncytin-2 Genes and Transcripts: How Noncoding RNAs May Affect Pregnancy in Patients with Systemic Lupus Erythematosus. | Interaction between Long Noncoding RNAs and Syncytin-1/Syncytin-2 Genes and Transcripts: How Noncoding RNAs May Affect Pregnancy in Patients with Systemic Lupus Erythematosus.
Talotta R., Free PMC Article | 02/16/2023 |
| ERVWE1 Reduces Hippocampal Neuron Density and Impairs Dendritic Spine Morphology through Inhibiting Wnt/JNK Non-Canonical Pathway via miR-141-3p in Schizophrenia. | ERVWE1 Reduces Hippocampal Neuron Density and Impairs Dendritic Spine Morphology through Inhibiting Wnt/JNK Non-Canonical Pathway via miR-141-3p in Schizophrenia.
Yao W, Zhou P, Yan Q, Wu X, Xia Y, Li W, Li X, Zhu F., Free PMC Article | 01/28/2023 |
| Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion. | Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
Fu Y, Song Y, Zhang J, Wei LP, Sun XR. | 01/28/2023 |
| Whole-genome sequencing identifies rare missense variants of WNT16 and ERVW-1 causing the systemic lupus erythematosus. | Whole-genome sequencing identifies rare missense variants of WNT16 and ERVW-1 causing the systemic lupus erythematosus.
Chen J, Zhang P, Chen H, Wang X, He X, Zhong J, Zheng H, Li X, Jakovlić I, Zhang Y, Chen Y, Shen B, Deng C, Wu Y. | 12/31/2022 |
| Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression. | Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression.
C West R, Ezashi T, B Schoolcraft W, Yuan Y. | 08/20/2022 |
| Impaired transcription of human endogenous retroviruses in the sperm with exception of syncytin 1: short communication. | Impaired transcription of human endogenous retroviruses in the sperm with exception of syncytin 1: short communication.
Bergallo M, Canosa S, Galliano I, Daprà V, Montanari P, Sestero M, Gennarelli G, Benedetto C, Revelli A, Tovo PA. | 10/30/2021 |
| Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer. | Analysis of KAP1 expression patterns and human endogenous retrovirus Env proteins in ovarian cancer.
Jeon KY, Ko EJ, Oh YL, Kim H, Eo WK, Kim A, Sun HG, Ock MS, Kim KH, Cha HJ. | 08/28/2021 |
| Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients. | Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients.
Balestrieri E, Minutolo A, Petrone V, Fanelli M, Iannetta M, Malagnino V, Zordan M, Vitale P, Charvet B, Horvat B, Bernardini S, Garaci E, di Francesco P, Sinibaldi Vallebona P, Sarmati L, Grelli S, Andreoni M, Perron H, Matteucci C., Free PMC Article | 07/17/2021 |
| The Association between Plasma ERVWE1 Concentrations and Affective Symptoms during Pregnancy: Is This a Friendly Alien? | The Association between Plasma ERVWE1 Concentrations and Affective Symptoms during Pregnancy: Is This a Friendly Alien?
Serati M, Esposito CM, Grassi S, Bollati V, Barkin JL, Buoli M., Free PMC Article | 04/17/2021 |
| Human endogenous retrovirus W family envelope protein (HERV-W env) facilitates the production of TNF-alpha and IL-10 by inhibiting MyD88s in glial cells. | Human endogenous retrovirus W family envelope protein (HERV-W env) facilitates the production of TNF-α and IL-10 by inhibiting MyD88s in glial cells.
Wang X, Wu X, Huang J, Li H, Yan Q, Zhu F. | 03/20/2021 |
| Cutaneous T-Cell Lymphoma (CTCL) Cell Line-Derived Extracellular Vesicles Contain HERV-W-Encoded Fusogenic Syncytin-1. | Cutaneous T-Cell Lymphoma (CTCL) Cell Line-Derived Extracellular Vesicles Contain HERV-W-Encoded Fusogenic Syncytin-1.
Laukkanen K, Saarinen M, Mallet F, Aatonen M, Hau A, Ranki A. | 03/6/2021 |
| The results showed that viral protein syncytin-1 could trigger the activation of C-reactive protein (CRP), which might explain the elevated CRP in sterile inflammation and exhibit a novel mechanism for regulation of inflammation by syncytin-1 in schizophrenia. | Syncytin-1, an endogenous retroviral protein, triggers the activation of CRP via TLR3 signal cascade in glial cells.
Wang X, Liu Z, Wang P, Li S, Zeng J, Tu X, Yan Q, Xiao Z, Pan M, Zhu F. | 02/2/2021 |
| The authors conclude that DNA demethylation of the endogenous retroviral loci ERVWE1 promoter in seminomas is a prerequisite for syncytin-1 derepression. | DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas.
Benešová M, Trejbalová K, Kovářová D, Vernerová Z, Hron T, Kučerová D, Hejnar J., Free PMC Article | 02/2/2021 |
| Taking together, these results suggest that Wnt/beta-catenin signal pathway activation-dependent up-regulation of syncytin-1 contributes to the pro-inflammatory factor TNF-alpha-enhanced fusion between oral squamous cell carcinoma cells and endothelial cells. | Up-regulation of syncytin-1 contributes to TNF-α-enhanced fusion between OSCC and HUVECs partly via Wnt/β-catenin-dependent pathway.
Yan TL, Wang M, Xu Z, Huang CM, Zhou XC, Jiang EH, Zhao XP, Song Y, Song K, Shao Z, Liu K, Shang ZJ., Free PMC Article | 02/2/2021 |
| Syncytin-1/HERV-W envelope is an early activation marker of leukocytes and is upregulated in multiple sclerosis patients. | Syncytin-1/HERV-W envelope is an early activation marker of leukocytes and is upregulated in multiple sclerosis patients.
Garcia-Montojo M, Rodriguez-Martin E, Ramos-Mozo P, Ortega-Madueño I, Dominguez-Mozo MI, Arias-Leal A, García-Martínez MÁ, Casanova I, Galan V, Arroyo R, Álvarez-Lafuente R, Villar LM. | 10/31/2020 |
| Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer. | Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
Li X, Fu Y, Xia X, Zhang X, Xiao K, Zhuang X, Zhang Y., Free PMC Article | 08/22/2020 |
| There was a difference (p < 0.0001) between trisomy 7 and other patient groups and controls, regarding to the expression of syncytin-1 gene. Numerous mutations in the syncytin-1 and syncytin-2 genes (on the expression sites) were detected, and the mutation rate was higher in the syncytin-1 gene compared to the syncytin-2 gene in the patient and in the control groups (p < 0.001) | Expression of the syncytin-1 and syncytin-2 genes in the trophoblastic tissue of the early pregnancy losses with normal and abnormal karyotypes.
Tug E, Yirmibes Karaoguz M, Nas T. | 04/25/2020 |
| Human syncytin-1, which is derived from human endogenous retrovirus W, requires a 3' untranslated region (3'UTR) for efficient gene expression. | Identification of a post-transcriptional regulatory element in the human endogenous retroviral syncytin-1.
Kitao K, Tanikaga T, Miyazawa T. | 12/21/2019 |
| Study finds that the radiosensitivity of T47D human breast carcinoma cells in tight clusters is different from that of isolated cells. Molecular analyses show that T47D cells express a Syncytin-1 homologous protein (SyHP). SyHP translocates to the external surface of the plasma membrane of cells killed by radiation treatment. | Collective radioresistance of T47D breast carcinoma cells is mediated by a Syncytin-1 homologous protein.
Chignola R, Sega M, Molesini B, Baruzzi A, Stella S, Milotti E., Free PMC Article | 09/28/2019 |
| These data revealed that human endogenous retrovirus W env might contribute to increase nitric oxide production and microglial migration ability in neuropsychological disorders by regulating the expression of inducible nitric oxide synthase. | Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase.
Xiao R, Li S, Cao Q, Wang X, Yan Q, Tu X, Zhu Y, Zhu F., Free PMC Article | 03/10/2018 |
| CD47 seems to mediate fusion mostly through broad contact surfaces between the partners' cell membrane while syncytin-1 mediate fusion through phagocytic-cup like structure. | Osteoclast Fusion: Time-Lapse Reveals Involvement of CD47 and Syncytin-1 at Different Stages of Nuclearity.
Møller AM, Delaissé JM, Søe K., Free PMC Article | 05/20/2017 |
| HERV-W was expressed in demyelinated lesions from multiple sclerosis brains, which were all positive for this endogenous pathogenic protein. Pronounced HERV-W immunoreactivity in active multiple sclerosis lesions was intimately associated with areas of active demyelination throughout the successive stages of lesion evolution in multiple sclerosis brains. | Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis.
van Horssen J, van der Pol S, Nijland P, Amor S, Perron H. | 03/4/2017 |