| CFHR1 involvement in bile duct carcinoma: Insights from a data mining study. | CFHR1 involvement in bile duct carcinoma: Insights from a data mining study.
Liu Y, Shen T, Liu J, Yu X, Li Q, Chen T, Jiang T. | 03/1/2024 |
| The absence of CFHR3 and CFHR1 genes from the T2T-CHM13 assembly can limit the molecular diagnosis of complement-related diseases. | The absence of CFHR3 and CFHR1 genes from the T2T-CHM13 assembly can limit the molecular diagnosis of complement-related diseases.
Hamza A, El-Sissy C, Yousfi N, Martins PV, Rafat C, Masliah-Planchon J, Frémeaux-Bacchi V, Mesnard L., | 07/23/2023 |
| CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome. | CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome.
Sugawara Y, Kato H, Nagasaki M, Yoshida Y, Fujisawa M, Minegishi N, Yamamoto M, Nangaku M., Free PMC Article | 05/30/2023 |
| CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome. | CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome.
Piras R, Valoti E, Alberti M, Bresin E, Mele C, Breno M, Liguori L, Donadelli R, Rigoldi M, Benigni A, Remuzzi G, Noris M., Free PMC Article | 02/17/2023 |
| Anti-factor H antibody and its role in atypical hemolytic uremic syndrome. | Anti-factor H antibody and its role in atypical hemolytic uremic syndrome.
Raina R, Mangat G, Hong G, Shah R, Nair N, Abboud B, Bagga S, Sethi SK., Free PMC Article | 10/1/2022 |
| Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy. | Factor H-Related Protein 1 Drives Disease Susceptibility and Prognosis in C3 Glomerulopathy.
Márquez-Tirado B, Gutiérrez-Tenorio J, Tortajada A, Lucientes Continente L, Caravaca-Fontán F, Malik TH, Roldán Montero R, Elías S, Saiz Gonzalez A, Fernández-Juarez G, Sánchez-Corral P, Pickering MC, Praga M, Rodríguez de Córdoba S, Goicoechea de Jorge E., Free PMC Article | 06/11/2022 |
| Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation. | Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.
Papp A, Papp K, Uzonyi B, Cserhalmi M, Csincsi ÁI, Szabó Z, Bánlaki Z, Ermert D, Prohászka Z, Erdei A, Ferreira VP, Blom AM, Józsi M., Free PMC Article | 04/23/2022 |
| High prevalence of CFHR deletions in Indian women with pregnancy-associated hemolytic uremic syndrome. | High prevalence of CFHR deletions in Indian women with pregnancy-associated hemolytic uremic syndrome.
Kandari S, Chakurkar V, Gaikwad S, Agarwal M, Phadke N, Lobo V. | 03/12/2022 |
| A synthetic protein as efficient multitarget regulator against complement over-activation. | A synthetic protein as efficient multitarget regulator against complement over-activation.
Ruiz-Molina N, Parsons J, Müller M, Hoernstein SNW, Bohlender LL, Pumple S, Zipfel PF, Häffner K, Reski R, Decker EL., Free PMC Article | 03/12/2022 |
| Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease. | Factor H-related protein 1 (FHR-1) is associated with atherosclerotic cardiovascular disease.
Irmscher S, Zipfel SLH, Halder LD, Ivanov L, Gonzalez-Delgado A, Waldeyer C, Seiffert M, Brunner FJ, von der Heide M, Löschmann I, Wulf S, Czamara D, Papac-Milicevic N, Strauß O, Lorkowski S, Reichenspurner H, Holers MV, Banda NK, Zeller T, Binder EB, Binder CJ, Wiech T, Zipfel PF, Skerka C., Free PMC Article | 02/26/2022 |
| Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases. | Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases.
Martin Merinero H, Subías M, Pereda A, Gómez-Rubio E, Juana Lopez L, Fernandez C, Goicoechea de Jorge E, Martin-Santamaria S, Cañada FJ, Rodríguez de Córdoba S., Free PMC Article | 12/4/2021 |
| Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces. | Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces.
Dopler A, Stibitzky S, Hevey R, Mannes M, Guariento M, Höchsmann B, Schrezenmeier H, Ricklin D, Schmidt CQ., Free PMC Article | 07/3/2021 |
| Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization. | Interaction of the Factor H Family Proteins FHR-1 and FHR-5 With DNA and Dead Cells: Implications for the Regulation of Complement Activation and Opsonization.
Kárpáti É, Papp A, Schneider AE, Hajnal D, Cserhalmi M, Csincsi ÁI, Uzonyi B, Józsi M., Free PMC Article | 04/17/2021 |
| Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection. | Deletions in Genes Participating in Innate Immune Response Modify the Clinical Course of Andes Orthohantavirus Infection.
Ribeiro GE, Leon LE, Perez R, Cuiza A, Vial PA, Ferres M, Mertz GJ, Vial C., Free PMC Article | 09/26/2020 |
| These findings provide a mechanistic explanation as to why the deletion of CFHR3 and CFHR1 is protective in AMD and highlight the importance of genetic variants within the CFH/CFHR3/CFHR1 locus in the recognition of altered-self in tissue homeostasis. | A genome-wide association study identifies key modulators of complement factor H binding to malondialdehyde-epitopes.
Alic L, Papac-Milicevic N, Czamara D, Rudnick RB, Ozsvar-Kozma M, Hartmann A, Gurbisz M, Hoermann G, Haslinger-Hutter S, Zipfel PF, Skerka C, Binder EB, Binder CJ., Free PMC Article | 08/1/2020 |
| Low levels of CFHR1 are specifically found in lung adenocarcinoma samples, and CFHR1 could serve as a potential therapeutic target for this subset of lung cancers. | CFHR1 is a potentially downregulated gene in lung adenocarcinoma.
Wu G, Yan Y, Wang X, Ren X, Chen X, Zeng S, Wei J, Qian L, Yang X, Ou C, Lin W, Gong Z, Zhou J, Xu Z., Free PMC Article | 02/8/2020 |
| These data highlight an unexpected role for FHR1 during sterile inflammation. | Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.
Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdauskas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C., Free PMC Article | 09/14/2019 |
| FHR-1 acts as a protective factor in human immunity by counteracting factor H-mediated microbial complement evasion | Cutting Edge: FHR-1 Binding Impairs Factor H-Mediated Complement Evasion by the Malaria Parasite Plasmodium falciparum.
Reiss T, Rosa TFA, Blaesius K, Bobbert RP, Zipfel PF, Skerka C, Pradel G. | 08/3/2019 |
| Here, we report the identification of mutations in the CFHR1 gene that generate by gene conversion events and that are undetectable by the current Next-generation massive parallel DNA sequencing (NGS) analysis approaches. | Factor H Competitor Generated by Gene Conversion Events Associates with Atypical Hemolytic Uremic Syndrome.
Goicoechea de Jorge E, Tortajada A, García SP, Gastoldi S, Merinero HM, García-Fernández J, Arjona E, Cao M, Remuzzi G, Noris M, Rodríguez de Córdoba S., Free PMC Article | 07/20/2019 |
| In conclusion, the CFHR3,1D genotype did not associate with progression toward CKD stages 3 and 5 in our white population of patients with IgAN, although it did associate with a reduced level of glomerular immune deposits. | Deletion Variants of CFHR1 and CFHR3 Associate with Mesangial Immune Deposits but Not with Progression of IgA Nephropathy.
Jullien P, Laurent B, Claisse G, Masson I, Dinic M, Thibaudin D, Berthoux F, Alamartine E, Mariat C, Maillard N., Free PMC Article | 07/13/2019 |
| Novel genetic rearrangement generated from a heterozygous deletion spanning 146 Kbp involving multiple CFHR genes leading to a CFHR1-R5 hybrid protein. This deletion was found in four family members presenting with a familial dominant glomerulopathy. | A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.
Togarsimalemath SK, Sethi SK, Duggal R, Le Quintrec M, Jha P, Daniel R, Gonnet F, Bansal S, Roumenina LT, Fremeaux-Bacchi V, Kher V, Dragon-Durey MA. | 05/26/2018 |
| Plasma FHR-1 and the FHR-1/fH ratio were elevated in IgA nephropathy and associated with progressive disease. | Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy.
Medjeral-Thomas NR, Lomax-Browne HJ, Beckwith H, Willicombe M, McLean AG, Brookes P, Pusey CD, Falchi M, Cook HT, Pickering MC., Free PMC Article | 05/26/2018 |
| A role of FHR-1 in IgA nephropathy pathogenesis is to compete with complement regulation by factor H. | Elevated factor H-related protein 1 and factor H pathogenic variants decrease complement regulation in IgA nephropathy.
Tortajada A, Gutiérrez E, Goicoechea de Jorge E, Anter J, Segarra A, Espinosa M, Blasco M, Roman E, Marco H, Quintana LF, Gutiérrez J, Pinto S, Lopez-Trascasa M, Praga M, Rodriguez de Córdoba S. | 05/26/2018 |
| We conclude that the relationship between complement-regulatory proteins CFHR1 and CFHR3 and response to anti-CD20 mAb therapy varies based on the specific anti-CD20 mAb used. | Complement-Regulatory Proteins CFHR1 and CFHR3 and Patient Response to Anti-CD20 Monoclonal Antibody Therapy.
Rogers LM, Mott SL, Smith BJ, Link BK, Sahin D, Weiner GJ., Free PMC Article | 02/17/2018 |
| To our knowledge, this is the first evaluation of the involvement of the CFHR3/CFHR1 deletion and age-related macular degeneration in CFH Y402H polymorphism Brazilian patients. | Evaluation of CFH Y402H polymorphism and CFHR3/CFHR1 deletion in age-related macular degeneration patients from Brazil.
Dezidério Sacconi DP, Cabral de Vasconcellos JP, Endo Hirata F, MacCord Medina F, Rim PH, Barbosa de Melo M. | 11/18/2017 |