| Evidence of an Annexin A4 mediated plasma membrane repair response to biomechanical strain associated with glaucoma pathogenesis. | Evidence of an Annexin A4 mediated plasma membrane repair response to biomechanical strain associated with glaucoma pathogenesis.
Vicic N, Guo X, Chan D, Flanagan JG, Sigal IA, Sivak JM., Free PMC Article | 10/15/2022 |
| Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma. | Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma.
Peng Y, Zhang Z, Zhang A, Liu C, Sun Y, Peng Z, Liu Y., Free PMC Article | 08/21/2021 |
| p53 and ANXA4/NFkappaB p50 complexes regulate cell proliferation, apoptosis and tumor progression in ovarian clear cell carcinoma. | p53 and ANXA4/NF‑κB p50 complexes regulate cell proliferation, apoptosis and tumor progression in ovarian clear cell carcinoma.
Liu J, Wang H, Zheng M, Deng L, Zhang X, Lin B., Free PMC Article | 07/10/2021 |
| Clinical Significance of Annexin A4 as a Biomarker in the Early Diagnosis of Hepatocellular Carcinoma. | Clinical Significance of Annexin A4 as a Biomarker in the Early Diagnosis of Hepatocellular Carcinoma.
Saad ZM, Fouad Y, Ali LH, Hassanin TM., Free PMC Article | 06/12/2021 |
| GSK3beta-Ikaros-ANXA4 signaling inhibits high-glucose-induced fibroblast migration. | GSK3β-Ikaros-ANXA4 signaling inhibits high-glucose-induced fibroblast migration.
Wang Y, Zheng X, Wang Q, Zheng M, Pang L. | 03/20/2021 |
| Bioinformatics analysis predicted that annexin A4 was a potential target gene of miR-203. Next, luciferase reporter assay confirmed that miR-203 could directly target annexin A4. | miR-203 Inhibits the Invasion and EMT of Gastric Cancer Cells by Directly Targeting Annexin A4.
Li J, Zhang B, Cui J, Liang Z, Liu K., Free PMC Article | 02/22/2020 |
| ANXA4 expression was increased at both the mRNA and protein level in the drugresistant ovarian cancer cells, and ANXA4 contained a Lewis(y) structure. ANXA4 overexpression can abnormally activate signaling pathways and regulate the expression of a numbers of factors, forming a positive feedback loop to induce the chemoresistance of ovarian cancer cells. | Lewis(y) antigen-mediated positive feedback loop induces and promotes chemotherapeutic resistance in ovarian cancer.
Liu J, Zheng M, Qi Y, Wang H, Liu M, Liu Q, Lin B. | 12/22/2018 |
| Annexin A4 binds to artificial membranes and generates curvature force initiated from free edges, whereas annexin A6 induces constriction force. | Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair.
Boye TL, Maeda K, Pezeshkian W, Sønder SL, Haeger SC, Gerke V, Simonsen AC, Nylandsted J., Free PMC Article | 09/15/2018 |
| Taken together, these data indicate that up-regulation of ANXA4 leads to activation of the NF-kappaB pathway and its target genes in a feedback regulatory mechanism via the p65 subunit, resulting in tumor growth in GBC. | Annexin A4-nuclear factor-κB feedback circuit regulates cell malignant behavior and tumor growth in gallbladder cancer.
Yao HS, Sun C, Li XX, Wang Y, Jin KZ, Zhang XP, Hu ZQ., Free PMC Article | 05/5/2018 |
| Upregulation and nuclear translocation of ANXA4 have been observed in the progression of colorectal cancer and ovarian serous carcinoma. Knockdown of ANXA4 attenuated migration in ovarian cancer and breast cancer cells. In contrast, knockdown of ANXA4 increased susceptibility to platinum in ovarian cancer and malignant mesothelioma cells. Review. | The role of annexin A4 in cancer.
Yao H, Sun C, Hu Z, Wang W. | 12/23/2017 |
| Study identifies ANXA4 and FLNA as up-regulated in buccal squamous cell carcinoma arising from oral submucous fibrosis. | Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis.
Liu W, Zeng L, Li N, Wang F, Jiang C, Guo F, Chen X, Su T, Xu C, Zhang S, Fang C., Free PMC Article | 09/30/2017 |
| Detecting ANXA2 and ANXA4 expression may aid the evaluation of cervical carcinoma prognosis. | Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer.
Choi CH, Chung JY, Chung EJ, Sears JD, Lee JW, Bae DS, Hewitt SM., Free PMC Article | 09/30/2017 |
| High ANXA4 expression is associated with metastasis of hepatocellular carcinoma. | Overexpression of annexin A4 indicates poor prognosis and promotes tumor metastasis of hepatocellular carcinoma.
Chen W, Chen L, Cai Z, Liang D, Zhao B, Zeng Y, Liu X, Liu J. | 02/18/2017 |
| annexin A4 can be regarded as an important molecular marker in triple-negative breast cancer prognosis. | The Role of Annexin A4 in Triple-Negative Breast Cancer Progression and Its Clinical Application.
Zhang ZG, Chen JN, Wang YD, Gao JT, Jin Y. | 01/14/2017 |
| role of annexin A4 in cancer | Annexin A4 and cancer.
Wei B, Guo C, Liu S, Sun MZ. | 04/2/2016 |
| Data shows that CYTB and ANXA4 overexpression may be involved in carcinogenesis and histopathological differentiation of ovarian clear cell carcinoma and suggest they may serve as a potential diagnostic biomarkers. | Cystatin B as a potential diagnostic biomarker in ovarian clear cell carcinoma.
Takaya A, Peng WX, Ishino K, Kudo M, Yamamoto T, Wada R, Takeshita T, Naito Z. | 12/12/2015 |
| these results suggest that AnxA4 is a novel direct negative regulator of AC5, adding a new facet to the functions of annexins. | Annexin A4 is a novel direct regulator of adenylyl cyclase type 5.
Heinick A, Husser X, Himmler K, Kirchhefer U, Nunes F, Schulte JS, Seidl MD, Rolfes C, Dedman JR, Kaetzel MA, Gerke V, Schmitz W, Müller FU. | 11/28/2015 |
| These findings indicate that the calcium-binding site in the ANXA4 repeat induces chemoresistance to the platinum-based drug by elevating the intracellular chloride concentration. | Annexin A4 induces platinum resistance in a chloride-and calcium-dependent manner.
Morimoto A, Serada S, Enomoto T, Kim A, Matsuzaki S, Takahashi T, Ueda Y, Yoshino K, Fujita M, Fujimoto M, Kimura T, Naka T., Free PMC Article | 08/8/2015 |
| Fhit delocalizes annexin A4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel. | Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.
Gaudio E, Paduano F, Spizzo R, Ngankeu A, Zanesi N, Gaspari M, Ortuso F, Lovat F, Rock J, Hill GA, Kaou M, Cuda G, Aqeilan RI, Alcaro S, Croce CM, Trapasso F., Free PMC Article | 08/9/2014 |
| enhanced expression of Anx A4 confers platinum resistance by promoting efflux of platinum drugs via ATP7A. | Annexin A4-conferred platinum resistance is mediated by the copper transporter ATP7A.
Matsuzaki S, Enomoto T, Serada S, Yoshino K, Nagamori S, Morimoto A, Yokoyama T, Kim A, Kimura T, Ueda Y, Fujita M, Fujimoto M, Kanai Y, Kimura T, Naka T. | 05/17/2014 |
| This study showed that overexpression and nuclear localization of annexin A4 are related to chemoresistance and poor survival in patients with serous papillary ovarian carcinomas. | Overexpression of annexin A4 is associated with chemoresistance in papillary serous adenocarcinoma of the ovary.
Choi CH, Sung CO, Kim HJ, Lee YY, Song SY, Song T, Kim J, Kim TJ, Lee JW, Bae DS, Kim BG. | 07/20/2013 |
| suggest that ANXA4 triggers a signaling cascade, leading to increased epithelial cell proliferation, ultimately promoting carcinogenesis | Revealing the molecular mechanism of gastric cancer marker annexin A4 in cancer cell proliferation using exon arrays.
Lin LL, Huang HC, Juan HF., Free PMC Article | 03/9/2013 |
| Lower expression of annexin A4 during window of implantation in infertile patients with endometriosis might be associated with the decrease of endometrial receptivity. | [Study on the relationship between altered expression of annexin A4 and endometrial receptivity during the implantation window in infertile patients with endometriosis].
Jiang YL, Li B, Xing FQ, Wang F, Feng JH. | 02/16/2013 |
| Eight ANXA4 polymorphisms are significantly associated with the risk of aspirin-exacerbated respiratory disease. | Potential association between ANXA4 polymorphisms and aspirin-exacerbated respiratory disease.
Park TJ, Kim JH, Bae JS, Park BL, Cheong HS, Pasaje CF, Park JS, Uh ST, Kim MK, Choi IS, Park CS, Shin HD. | 12/8/2012 |
| ANXA1 and, to a lesser extent, ANXA4 were detected on late but not early apoptotic HeLa cells. | Suppression of MIP-2 or IL-8 production by annexins A1 and A4 during coculturing of macrophages with late apoptotic human peripheral blood neutrophils.
Iwasa T, Takahashi R, Nagata K, Kobayashi Y. | 07/14/2012 |