| Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine gamma-lyase expression in a rat model of intracerebral hemorrhage. | Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine γ-lyase expression in a rat model of intracerebral hemorrhage.
Liang T, Xu S, Liu R, Xia X., Free PMC Article | 05/28/2024 |
| CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma. | CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma.
Ishteyaque S, Yadav KS, Verma S, Washimkar KR, Mugale MN. | 08/30/2023 |
| Dual role of endoplasmic reticulum stress-ATF-6 activation in autophagy and apoptosis induced by cyclic stretch in myoblast. | Dual role of endoplasmic reticulum stress-ATF-6 activation in autophagy and apoptosis induced by cyclic stretch in myoblast.
Zhang Q, Liu G, Liu R, Liu J, Zeng X, Ren D, Yan X, Yuan X. | 06/13/2023 |
| MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6. | MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6.
Xia H, Zhao H, Yang W, Luo X, Wei J, Xia H. | 04/16/2022 |
| Molecular Mechanism of the ATF6alpha/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats. | Molecular Mechanism of the ATF6α/S1P/S2P Signaling Pathway in Hippocampal Neuronal Apoptosis in SPS Rats.
Han L, Xu Y, Shi Y. | 03/5/2022 |
| Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels. | Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels.
Bektur Aykanat NE, Şahin E, Kaçar S, Bağcı R, Karakaya Ş, Burukoğlu Dönmez D, Şahintürk V. | 02/26/2022 |
| MicroRNA-211-5p attenuates spinal cord injury via targeting of activating transcription factor 6. | MicroRNA-211-5p attenuates spinal cord injury via targeting of activating transcription factor 6.
Zhang H, Piao M, Guo M, Meng L, Yu H. | 08/14/2021 |
| The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes. | The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
Marsh KG, Arrieta A, Thuerauf DJ, Blackwood EA, MacDonnell L, Glembotski CC., Free PMC Article | 05/15/2021 |
| ER stress mediatedautophagy contributes to neurological dysfunction in traumatic brain injury via the ATF6 UPR signaling pathway. | ER stress mediated‑autophagy contributes to neurological dysfunction in traumatic brain injury via the ATF6 UPR signaling pathway.
Wang DY, Hong MY, Pei J, Gao YH, Zheng Y, Xu X. | 05/8/2021 |
| The results showed that both Unfolded Protein Response (Xbp-1, its spliced variant sXbp-1, Atf-6, Chop, and Grp94) and Toll like receptor (2, 3, 4, 7 and 9) genes were significantly upregulated in the hippocampi of rats who were exposed to restraint stress. | Unfolded protein response and associated alterations in toll-like receptor expression and interaction in the hippocampus of restraint rats.
Timberlake M 2nd, Prall K, Roy B, Dwivedi Y., Free PMC Article | 01/5/2019 |
| The findings demonstrate reciprocal regulation of the unfolded protein response, including ATF6alpha activation and endoplasmic reticulum expansion, and reduced contractile differentiation in bladder outlet obstruction occurring independently of thrombospondin-4, which however is a sensitive indicator of obstruction. | Assessing the contribution of thrombospondin-4 induction and ATF6α activation to endoplasmic reticulum expansion and phenotypic modulation in bladder outlet obstruction.
Krawczyk KK, Ekman M, Rippe C, Grossi M, Nilsson BO, Albinsson S, Uvelius B, Swärd K., Free PMC Article | 05/19/2018 |
| these results confirmed that ER stress-mediated apoptosis contributes to the protection effects of naringenin against H/R injury, which is potentially involved in ATF6, IRE1alpha and PERK signaling activation. | Naringenin ameliorates hypoxia/reoxygenation-induced endoplasmic reticulum stress-mediated apoptosis in H9c2 myocardial cells: involvement in ATF6, IRE1α and PERK signaling activation.
Tang JY, Jin P, He Q, Lu LH, Ma JP, Gao WL, Bai HP, Yang J. | 02/18/2017 |
| ATF6 upregulation is involved in the mechanism by which CIH attenuates myocardial I/R injury, possibly through upregulation of p-Akt, which is a key regulator of cardiomyocyte survival. | Upregulated ATF6 contributes to chronic intermittent hypoxia-afforded protection against myocardial ischemia/reperfusion injury.
Jia W, Jian Z, Li J, Luo L, Zhao L, Zhou Y, Tang F, Xiao Y., Free PMC Article | 12/31/2016 |
| Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. | ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy.
Liu L, Liu C, Lu Y, Liu L, Jiang Y., Free PMC Article | 06/4/2016 |
| Single prolonged stress activates the ATF6alpha branch of the endoplasmic stress response, which may be contributed to the pathogenesis of PTSD. | Single-prolonged stress activates the transcription factor ATF6α branch of the unfolded protein response in rat neurons of dorsal raphe nucleus.
Xie J, Han F, Shi Y. | 08/22/2015 |
| Study highlights that single-prolonged stress induced ATF6alpha-dependent endoplasmic reticulum stress and ER-related apoptosis in the prefrontal cortex neurons | Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons.
Yu B, Wen L, Xiao B, Han F, Shi Y., Free PMC Article | 07/25/2015 |
| No ethanol-induced increase in thapsigargin-mediated expression of ATF6 in Purkinje neurons somas nor was there expression detectable within the dendrites | ATF6 and caspase 12 expression in Purkinje neurons in acute slices from adult, ethanol-fed rats.
Dlugos CA. | 04/4/2015 |
| ATF6beta is not essential for induction of most UPR genes, but is required to maintain cell survival in beta-cells undergoing chronic ER stress. | ATF6β regulates the Wfs1 gene and has a cell survival role in the ER stress response in pancreatic β-cells.
Odisho T, Zhang L, Volchuk A. | 02/21/2015 |
| ATF6 was activated in reactive oxygen species-mediated endoplasmic reticulum stress-induced apoptosis in a rat model of diabetic cardiomyopathy. | Protein kinase RNA-like endoplasmic reticulum kinase (PERK) signaling pathway plays a major role in reactive oxygen species (ROS)-mediated endoplasmic reticulum stress-induced apoptosis in diabetic cardiomyopathy.
Liu ZW, Zhu HT, Chen KL, Dong X, Wei J, Qiu C, Xue JH., Free PMC Article | 09/6/2014 |
| 4-Phenylbutyric acid analogues strongly inhibited activation of the IRE1 and ATF6 pathways and downstream pathogenic targets, including NF-kappaB and Akt, in endoplasmic reticulum stress-exposed cells. | Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues.
Zhang H, Nakajima S, Kato H, Gu L, Yoshitomi T, Nagai K, Shinmori H, Kokubo S, Kitamura M., Free PMC Article | 08/23/2014 |
| although ATF6 binds directly to the A5/Core of the rat insulin II gene promoter, this direct binding does not appear to contribute to its repressive activity. | Binding of activating transcription factor 6 to the A5/Core of the rat insulin II gene promoter does not mediate its transcriptional repression.
Amyot J, Benterki I, Fontés G, Hagman DK, Ferdaoussi M, Teodoro T, Volchuk A, Joly É, Poitout V., Free PMC Article | 02/18/2012 |
| Rat transgenic ATF6 activation decreased ischemic damage in an ex vivo model of myocardial ischemia/reperfusion and induced numerous genes, including mesencephalic astrocyte-derived neurotrophic factor. | Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart.
Tadimalla A, Belmont PJ, Thuerauf DJ, Glassy MS, Martindale JJ, Gude N, Sussman MA, Glembotski CC., Free PMC Article | 01/21/2010 |
| ER stress-induced activation of ATF6 plays an important role in the development of beta-cell dysfunction. | Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner.
Seo HY, Kim YD, Lee KM, Min AK, Kim MK, Kim HS, Won KC, Park JY, Lee KU, Choi HS, Park KG, Lee IK., Free PMC Article | 01/21/2010 |
| RCAN1 is a novel ATF6-inducible gene that may also be a novel integrator of growth and ER stress signaling in many other tissues that depend on calcineurin/NFAT signaling for optimal growth and development | Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene.
Belmont PJ, Tadimalla A, Chen WJ, Martindale JJ, Thuerauf DJ, Marcinko M, Gude N, Sussman MA, Glembotski CC., Free PMC Article | 01/21/2010 |