| The Role and Mechanism of STIM1/Orai1-Regulated Ca[2+] Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus. | The Role and Mechanism of STIM1/Orai1-Regulated Ca(2+) Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus.
Zhang S, Zang W. | 03/28/2024 |
| Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction. | Inhibition of adenylyl cyclase 8 prevents the upregulation of Orai1 channel, which improves cardiac function after myocardial infarction.
Falcón D, Calderón-Sánchez EM, Mayoral-González I, Martín-Bórnez M, Dominguez-Rodriguez A, Gutiérrez-Carretero E, Ordóñez-Fernández A, Rosado JA, Smani T., | 03/13/2024 |
| Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries. | Upregulation of Orai Channels Contributes to Aging-Related Vascular Alterations in Rat Coronary Arteries.
Angulo J, Fernández A, Sevilleja-Ortiz A, Sánchez-Ferrer A, Rodríguez-Mañas L, El Assar M., Free PMC Article | 11/18/2023 |
| Inhibition of altered Orai1 channels in Muller cells protects photoreceptors in retinal degeneration. | Inhibition of altered Orai1 channels in Müller cells protects photoreceptors in retinal degeneration.
Sukkar B, Oktay L, Sahaboglu A, Moayedi A, Zenouri S, Al-Maghout T, Cantó A, Miranda M, Durdagi S, Hosseinzadeh Z. | 09/7/2023 |
| Suppression of store-operated Ca(2+) entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion. | Suppression of store-operated Ca(2+) entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion.
Zhu M, Lv B, Ge W, Cui Z, Zhao K, Feng Y, Yang X., Free PMC Article | 12/4/2021 |
| Role of Orai1 and L-type CaV1.2 channels in Endothelin-1 mediated coronary contraction under ischemia and reperfusion. | Role of Orai1 and L-type Ca(V)1.2 channels in Endothelin-1 mediated coronary contraction under ischemia and reperfusion.
Calderón-Sánchez EM, Ávila-Medina J, Callejo-García P, Fernández-Velasco M, Ordóñez A, Smani T. | 06/5/2021 |
| TRPM7 activation potentiates SOCE in enamel cells but requires ORAI. | TRPM7 activation potentiates SOCE in enamel cells but requires ORAI.
Souza Bomfim GH, Costiniti V, Li Y, Idaghdour Y, Lacruz RS., Free PMC Article | 06/5/2021 |
| Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension. | Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension.
Dhande IS, Zhu Y, Kneedler SC, Joshi AS, Hicks MJ, Wenderfer SE, Braun MC, Doris PA., Free PMC Article | 12/19/2020 |
| These data suggest that Orai1 SOCE is a potential therapeutic target in AKI and CKD progression. | Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury.
Mehrotra P, Sturek M, Neyra JA, Basile DP., Free PMC Article | 06/13/2020 |
| ORAI1 and STIM1 expression decreased in the ipsilateral temporoparietal cortex subjected to middle cerebral artery occlusion. | ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection Induced by Ischemic Preconditioning Through Store-Operated Calcium Entry.
Secondo A, Petrozziello T, Tedeschi V, Boscia F, Vinciguerra A, Ciccone R, Pannaccione A, Molinaro P, Pignataro G, Annunziato L. | 01/11/2020 |
| STIM1L/Orai1/TRPC1/C4-dependent Ca(2+) current participates in Ca(2+) remodeling in right ventricular hypertrophy secondary to pulmonary hypertension. | Ca(2+) handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
Sabourin J, Boet A, Rucker-Martin C, Lambert M, Gomez AM, Benitah JP, Perros F, Humbert M, Antigny F. | 06/29/2019 |
| When exposed to high tidal volume or large-magnitude CS, Stim1 and Orai1 expression are upregulated, which further activates calcium-sensitive PKCalpha and results in calcium overload, endothelial hyperpermeability, and, finally, lung injury. | Stromal-Interacting Molecule 1 (Stim1)/Orai1 Modulates Endothelial Permeability in Ventilator-Induced Lung Injury.
Song X, Liu Y, Dong L, Wang Y., Free PMC Article | 03/9/2019 |
| Coimmunoprecipitation assays revealed the presence and interaction of all store-operated Ca(2+) influx channel components in the injured vascular smooth muscle cells, where Homer1 interacts with Orai1 and various TRPC channels. | Homer binds to Orai1 and TRPC channels in the neointima and regulates vascular smooth muscle cell migration and proliferation.
Jia S, Rodriguez M, Williams AG, Yuan JP., Free PMC Article | 02/2/2019 |
| Cholesterol regulates the interaction of Orai1 and stromal interaction molecule 1 required for pulmonary endothelial store-operated Ca(2+) entry. | Reduced membrane cholesterol after chronic hypoxia limits Orai1-mediated pulmonary endothelial Ca(2+) entry.
Zhang B, Naik JS, Jernigan NL, Walker BR, Resta TC., Free PMC Article | 01/19/2019 |
| the declined Orai1 expression, at least partly, contributes to the downregulated Ca(2+) entry during lymphocyte excitation, providing an important mechanism for T lymphocyte malfunction in diabetes. | Orai1 downregulation impairs lymphocyte function in type 2 diabetes mellitus.
Wang H, Wang C, Wang L, Liu T, Wang Z, You H, Zheng Y, Luo D. | 09/22/2018 |
| Store operated calcium channels are associated with diabetic cystopathy in streptozotocininduced diabetic rats. | Store operated calcium channels are associated with diabetic cystopathy in streptozotocin‑induced diabetic rats.
Yang S, Wang D, Cao X, Zhang X, Yuan X, Yang T, Mi Y., Free PMC Article | 09/15/2018 |
| these results demonstrated that NEFA-sensitive NFkappaB-dependent Orai1 expression regulates de novo lipogenesis. | NEFA-Sensitive Orai1 Expression in Regulation of De Novo Lipogenesis.
Zhang B, Yang W, Zou Y, Li M, Guo H, Zhang H, Xia C, Xu C. | 08/18/2018 |
| Using dominant negative form of ORAI1, we were able to show that ORAI1 is needed for formation of new dendritic spines following chemical induction of long term potentiation (cLTP), and that this is due to the release of Ca(+2) from ryanodine receptor-associated endoplasmic reticulum stores. | ORAI1-dependent synaptic plasticity in rat hippocampal neurons.
Tshuva RY, Korkotian E, Segal M. | 02/24/2018 |
| Hypertrophic aortic remodeling and abnormal contraction triggered mainly by Ca2+ overload via STIM-1/Orai-1-mediated SOCE through SOCCs are involved hypertension developed by EtOH consumption. | Functional Upregulation of STIM-1/Orai-1-Mediated Store-Operated Ca2+ Contributing to the Hypertension Development Elicited by Chronic EtOH Consumption.
Souza Bomfim GH, Mendez-Lopez I, Arranz-Tagarro JA, Ferraz Carbonel AA, Roman-Campos D, Padín JF, Garcia AG, Jurkiewicz A, Jurkiewicz NH. | 12/16/2017 |
| Ang-II-induced Egr-1 expression is mediated by STIM-1/Orai-1/Ca(2+) -dependent signaling pathways in vascular smooth muscle cells. | STIM-1 and ORAI-1 channel mediate angiotensin-II-induced expression of Egr-1 in vascular smooth muscle cells.
Simo-Cheyou ER, Tan JJ, Grygorczyk R, Srivastava AK. | 10/7/2017 |
| Influx of calcium through Orai1 channels facilitates the maturation of dendritic spines and the formation of functional synapses in central neurons | The role of the store-operated calcium entry channel Orai1 in cultured rat hippocampal synapse formation and plasticity.
Korkotian E, Oni-Biton E, Segal M., Free PMC Article | 09/30/2017 |
| Neuronal aging is associated to increased ER-mitochondrial cross talking and loss of store-operated calcium entry via Stim1/Orai1. | In vitro aging promotes endoplasmic reticulum (ER)-mitochondria Ca(2+) cross talk and loss of store-operated Ca(2+) entry (SOCE) in rat hippocampal neurons.
Calvo-Rodríguez M, García-Durillo M, Villalobos C, Núñez L. | 07/1/2017 |
| in endotoxemia, Ca(2+) homeostasis is disrupted in VSMC, with decreased Ca(2+) influx, smaller concentrations of Ca(2+) in the sarcoplasmic reticulum, and decreased activation of Orai1 | Impaired Ca(2+) Homeostasis and Decreased Orai1 Expression Modulates Arterial Hyporeactivity to Vasoconstrictors During Endotoxemia.
Nonato AO, Olivon VC, Dela Justina V, Zanotto CZ, Webb RC, Tostes RC, Lima VV, Giachini FR. | 03/11/2017 |
| store-operated calcium entry may play a critical role in severe acute pancreitis-associated acute lung injury; and the protective effects of inhibition of SOC proteins Orai1 and STIM1 could be mediated, at least partially, by restraining mitochondrial associated apoptosis of pulmonary microvascular endothelial cells | Inhibition of SOCs Attenuates Acute Lung Injury Induced by Severe Acute Pancreatitis in Rats and PMVECs Injury Induced by Lipopolysaccharide.
Wang G, Zhang J, Xu C, Han X, Gao Y, Chen H. | 03/11/2017 |
| Orai1 gene expression is upregulated by aldosterone in rat cardiomyocytes. | Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.
Sabourin J, Bartoli F, Antigny F, Gomez AM, Benitah JP., Free PMC Article | 11/19/2016 |