| HAS2 facilitates glioma cell malignancy and suppresses ferroptosis in an FZD7-dependent manner. | HAS2 facilitates glioma cell malignancy and suppresses ferroptosis in an FZD7-dependent manner.
Liu Z, Yu K, Chen K, Liu J, Dai K, Zhao P., Free PMC Article | 09/18/2024 |
| Upregulation of HAS2 promotes glioma cell proliferation and chemoresistance via c-myc. | Upregulation of HAS2 promotes glioma cell proliferation and chemoresistance via c-myc.
Wang J, Ruan S, Yu T, Meng X, Ran J, Cen C, Kong C, Bao X, Li Z, Wang Y, Ren M, Guo P, Teng Y, Zhang D. | 06/21/2024 |
| Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis. | Unravelling the role of HAS2, GREM1, and PTGS2 gene expression in cumulus cells: implications for human oocyte development competency - a systematic review and integrated bioinformatic analysis.
Faizal AM, Elias MH, Jin NM, Abu MA, Syafruddin SE, Zainuddin AA, Suzuki N, Karim AKA., Free PMC Article | 03/27/2024 |
| MicroRNA-376b is involved in the pathogenesis of thyroid-associated ophthalmopathy by regulating HAS2. | MicroRNA-376b is involved in the pathogenesis of thyroid-associated ophthalmopathy by regulating HAS2.
Liu R, Ye Z, Liu Q, Xuan M, Li R, Zhang L, Zhang K, Fang P, Xue Y. | 08/30/2023 |
| Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression. | Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression.
Sato S, Miyazaki M, Fukuda S, Mizutani Y, Mizukami Y, Higashiyama S, Inoue S., Free PMC Article | 07/7/2023 |
| Downregulation of HAS-2 regulates the chondrocyte cytoskeleton and induces cartilage degeneration by activating the RhoA/ROCK signaling pathway. | Downregulation of HAS‑2 regulates the chondrocyte cytoskeleton and induces cartilage degeneration by activating the RhoA/ROCK signaling pathway.
Yang J, Wang L, Zhang Z, Sun Q, Zhang Y., Free PMC Article | 05/30/2023 |
| The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-beta Signaling and Upregulating HAS2. | The Upregulation of HAS2-AS1 Relates to the Granulosa Cell Dysfunction by Repressing TGF-β Signaling and Upregulating HAS2.
Xiang Y, Yu G, Song Y, Li Y, Cheng L, Li P, Zhang L, Wang M, Tan L., Free PMC Article | 10/8/2022 |
| 3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension. | 3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.
Tseng V, Collum SD, Allawzi A, Crotty K, Yeligar S, Trammell A, Ryan Smith M, Kang BY, Sutliff RL, Ingram JL, Jyothula SSSK, Thandavarayan RA, Huang HJ, Nozik ES, Wagner EJ, Michael Hart C, Karmouty-Quintana H., Free PMC Article | 09/10/2022 |
| Placental and endothelial biomarkers for the prediction of superimposed pre-eclampsia in chronic kidney disease. | Placental and endothelial biomarkers for the prediction of superimposed pre-eclampsia in chronic kidney disease.
Wiles K, Bramham K, Seed PT, Brockbank A, Nelson-Piercy C, Karumanchi SA, Lightstone L, Chappell LC. | 11/13/2021 |
| Hyaluronan synthase 2 (HAS2) regulates cell phenotype and invadopodia formation in luminal-like breast cancer cells. | Hyaluronan synthase 2 (HAS2) regulates cell phenotype and invadopodia formation in luminal-like breast cancer cells.
Sheng Y, Cao M, Liu Y, He Y, Zhang G, Du Y, Gao F, Yang C. | 09/11/2021 |
| GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2. | GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2.
Wang J, Teng F, Chai H, Zhang C, Liang X, Yang Y., Free PMC Article | 08/7/2021 |
| Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer. | Increased SPHK1 and HAS2 Expressions Correlate to Poor Prognosis in Pancreatic Cancer.
Yu M, Zhang K, Wang S, Xue L, Chen Z, Feng N, Ning C, Wang L, Li J, Zhang B, Yang C, Zhang Z., Free PMC Article | 06/19/2021 |
| Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis. | Epidermal growth factor promotes stromal cells migration and invasion via up-regulation of hyaluronate synthase 2 and hyaluronan in endometriosis.
Zhan H, Peng B, Ma J, Lin K, Xu K, Lin J, Yong PJ, Leung PCK, Bedaiwy MA, Lin J. | 05/22/2021 |
| Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells. | Hyaluronan Synthases' Expression and Activity Are Induced by Fluid Shear Stress in Bone Marrow-Derived Mesenchymal Stem Cells.
Reiprich S, Akova E, Aszódi A, Schönitzer V., Free PMC Article | 04/24/2021 |
| The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38/ATF2 and JAK2/STAT3 Cascades. | The Attenuated Secretion of Hyaluronan by UVA-Exposed Human Fibroblasts Is Associated with Up- and Downregulation of HYBID and HAS2 Expression via Activated and Inactivated Signaling of the p38/ATF2 and JAK2/STAT3 Cascades.
Terazawa S, Takada M, Sato Y, Nakajima H, Imokawa G., Free PMC Article | 04/17/2021 |
| TGF-beta/SMAD4 signaling pathway activates the HAS2-HA system to regulate granulosa cell state. | TGF-β/SMAD4 signaling pathway activates the HAS2-HA system to regulate granulosa cell state.
Li X, Du X, Yao W, Pan Z, Li Q. | 12/19/2020 |
| Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-kappaB and expression of the long-noncoding RNA HAS2-AS1. | Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-κB and expression of the long-noncoding RNA HAS2-AS1.
Caon I, Bartolini B, Moretto P, Parnigoni A, Caravà E, Vitale DL, Alaniz L, Viola M, Karousou E, De Luca G, Hascall VC, Passi A, Vigetti D., Free PMC Article | 12/12/2020 |
| HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts. | HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts.
Yoshida H, Aoki M, Komiya A, Endo Y, Kawabata K, Nakamura T, Sakai S, Sayo T, Okada Y, Takahashi Y., Free PMC Article | 10/24/2020 |
| Estrogen-Mediated MicroRNA-101-3p Expression Represses Hyaluronan Synthase 2 in Synovial Fibroblasts From Idiopathic Condylar Resorption Patients. | Estrogen-Mediated MicroRNA-101-3p Expression Represses Hyaluronan Synthase 2 in Synovial Fibroblasts From Idiopathic Condylar Resorption Patients.
Feng C, Ji P, Luo P, Xu J. | 08/13/2020 |
| Results indicated that the HAS2-OE expression system inhibits MMP3, MMP13, and other markers of the procatabolic phenotype (such as TNF-stimulated gene 6 protein (TSG6)) and also enhances aggrecan retention. | Hyaluronan synthase 2 (HAS2) overexpression diminishes the procatabolic activity of chondrocytes by a mechanism independent of extracellular hyaluronan.
Ishizuka S, Tsuchiya S, Ohashi Y, Terabe K, Askew EB, Ishizuka N, Knudson CB, Knudson W., Free PMC Article | 05/16/2020 |
| Results indicate that post-translational modifications control the trafficking of HAS2, and that trafficking is an integral part of the post-translational regulation of HAS2 activity. | Effects of mutations in the post-translational modification sites on the trafficking of hyaluronan synthase 2 (HAS2).
Melero-Fernandez de Mera RM, Arasu UT, Kärnä R, Oikari S, Rilla K, Vigetti D, Passi A, Heldin P, Tammi MI, Deen AJ. | 12/7/2019 |
| There was a higher HAS1 and HAS2 reactivity and lower HAS3 reactivity in the PCOS endometrium compared to women with regular menstrual cycles in the proliferative phase. | Analysis of hyaluronic acid in the endometrium of women with polycystic ovary syndrome.
Santos Simões R, Carbonel AAF, Borges FT, Baracat MCP, da Silva Sasso GR, Simões MJ, Serafini PC, Soares JM Júnior, Nader HB, Baracat EC. | 08/17/2019 |
| HAS2 is preferentially overexpressed in malignant-type colorectal cancer (CRC) cancer cells compared with that in mild-type CRC. HAS2 is a critical regulator for the malignant behavior of CRC such as therapeutic resistance or metastatic ability. Importantly, HAS2 promoted CRC malignancy through hyaluronic acid-independent TGF-beta regulation. | Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling.
Kim YH, Lee SB, Shim S, Kim A, Park JH, Jang WS, Lee SJ, Myung JK, Park S, Lee SJ, Kim MJ., Free PMC Article | 07/20/2019 |
| recruitment of the forkhead protein FOXH1 on open chromatin regions integrates the signals of Activin/Smad2 and Wnt/beta-catenin to activate the expression of the ME genes including HAS2 and ALDH3A2 Consistently, H3K27me3 decrease is enriched on open chromatin around regulatory regions | Activin/Smad2 and Wnt/β-catenin up-regulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human embryonic stem cells.
Xu X, Wang L, Liu B, Xie W, Chen YG., Free PMC Article | 05/4/2019 |
| This study indicates that elevated expression of HAS2 is associated with glioma progression | Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas.
Valkonen M, Haapasalo H, Rilla K, Tyynelä-Korhonen K, Soini Y, Pasonen-Seppänen S., Free PMC Article | 02/9/2019 |