| SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA. | SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.
Germani S, Van Ho AT, Cherubini A, Varone E, Chernorudskiy A, Renna GM, Fumagalli S, Gobbi M, Lucchetti J, Bolis M, Guarrera L, Craparotta I, Rastelli G, Piccoli G, de Napoli C, Nogara L, Poggio E, Brini M, Cattaneo A, Bachi A, Simmen T, Calì T, Quijano-Roy S, Boncompagni S, Blaauw B, Ferreiro A, Zito E., Free PMC Article | 03/25/2024 |
| Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1alpha) in human cancer. | Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer.
Chen P, Sharma A, Weiher H, Schmidt-Wolf IGH., Free PMC Article | 03/13/2024 |
| ERO1alpha promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway. | ERO1α promotes the proliferation and inhibits apoptosis of colorectal cancer cells by regulating the PI3K/AKT pathway.
Wu M, Li R, Qin J, Wang Z, Guo J, Lv F, Wang G, Huang Y. | 11/16/2023 |
| Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity. | Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity.
Liu L, Li S, Qu Y, Bai H, Pan X, Wang J, Wang Z, Duan J, Zhong J, Wan R, Fei K, Xu J, Yuan L, Wang C, Xue P, Zhang X, Ma Z, Wang J., Free PMC Article | 11/1/2023 |
| ERO1alpha primes the ryanodine receptor to respond to arsenite with concentration dependent Ca[2+] release sequentially triggering two different mechanisms of ROS formation. | ERO1α primes the ryanodine receptor to respond to arsenite with concentration dependent Ca(2+) release sequentially triggering two different mechanisms of ROS formation.
Guidarelli A, Spina A, Buffi G, Blandino G, Fiorani M, Cantoni O. | 09/22/2023 |
| Endoplasmic reticulum oxidoreductin 1-alpha deficiency and activation of protein translation synergistically impair breast tumour resilience. | Endoplasmic reticulum oxidoreductin 1-alpha deficiency and activation of protein translation synergistically impair breast tumour resilience.
Varone E, Decio A, Barbera MC, Bolis M, Di Rito L, Pisati F, Giavazzi R, Zito E., Free PMC Article | 11/12/2022 |
| ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA. | ERO1 alpha deficiency impairs angiogenesis by increasing N-glycosylation of a proangiogenic VEGFA.
Varone E, Chernorudskiy A, Cherubini A, Cattaneo A, Bachi A, Fumagalli S, Erol G, Gobbi M, Lenardo MJ, Borgese N, Zito E., Free PMC Article | 10/8/2022 |
| ERO1L promotes the proliferation and metastasis of lung adenocarcinoma via the Wnt2/beta-catenin signaling pathway. | ERO1L promotes the proliferation and metastasis of lung adenocarcinoma via the Wnt2/β-catenin signaling pathway.
Xie J, Liao G, Feng Z, Liu B, Li X, Qiu M. | 10/1/2022 |
| Crosstalk between ERO1alpha and ryanodine receptor in arsenite-dependent mitochondrial ROS formation. | Crosstalk between ERO1α and ryanodine receptor in arsenite-dependent mitochondrial ROS formation.
Spina A, Guidarelli A, Fiorani M, Varone E, Catalani A, Zito E, Cantoni O. | 05/7/2022 |
| ERO1-PDI Redox Signaling in Health and Disease. | ERO1-PDI Redox Signaling in Health and Disease.
Jha V, Kumari T, Manickam V, Assar Z, Olson KL, Min JK, Cho J., Free PMC Article | 04/2/2022 |
| ERO1L Promotes Hepatic Metastasis through Activating Epithelial-Mesenchymal Transition (EMT) in Pancreatic Cancer. | ERO1L Promotes Hepatic Metastasis through Activating Epithelial-Mesenchymal Transition (EMT) in Pancreatic Cancer.
Yang J, Xu Y, Huo Y, Cai L, Hua R, Zhang J, Chen Z., Free PMC Article | 11/6/2021 |
| ERO1L Is a Novel and Potential Biomarker in Lung Adenocarcinoma and Shapes the Immune-Suppressive Tumor Microenvironment. | ERO1L Is a Novel and Potential Biomarker in Lung Adenocarcinoma and Shapes the Immune-Suppressive Tumor Microenvironment.
Liu L, Wang C, Li S, Qu Y, Xue P, Ma Z, Zhang X, Bai H, Wang J., Free PMC Article | 10/30/2021 |
| The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells. | The NFIB-ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells.
Zilli F, Marques Ramos P, Auf der Maur P, Jehanno C, Sethi A, Coissieux MM, Eichlisberger T, Sauteur L, Rouchon A, Bonapace L, Pinto Couto J, Rad R, Jensen MR, Banfi A, Stadler MB, Bentires-Alj M., Free PMC Article | 10/30/2021 |
| ERO1alpha mediates endoplasmic reticulum stress-induced apoptosis via microRNA-101/EZH2 axis in colon cancer RKO and HT-29 cells. | ERO1α mediates endoplasmic reticulum stress-induced apoptosis via microRNA-101/EZH2 axis in colon cancer RKO and HT-29 cells.
Wang G, Han J, Wang G, Wu X, Huang Y, Wu M, Chen Y. | 10/9/2021 |
| The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions. | The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions.
Varone E, Decio A, Chernorudskiy A, Minoli L, Brunelli L, Ioli F, Piotti A, Pastorelli R, Fratelli M, Gobbi M, Giavazzi R, Zito E., Free PMC Article | 07/31/2021 |
| ERO1L promotes NSCLC development by modulating cell cycle-related molecules. | ERO1L promotes NSCLC development by modulating cell cycle-related molecules.
Shi X, Wu J, Liu Y, Jiang Y, Zhi C, Li J., Free PMC Article | 07/10/2021 |
| ERO1L promotes IL6/sIL6R signaling and regulates MUC16 expression to promote CA125 secretion and the metastasis of lung cancer cells. | ERO1L promotes IL6/sIL6R signaling and regulates MUC16 expression to promote CA125 secretion and the metastasis of lung cancer cells.
Lei Y, Zang R, Lu Z, Zhang G, Huang J, Liu C, Wang Z, Mao S, Che Y, Wang X, Zheng S, Fang L, Sun N, He J., Free PMC Article | 05/15/2021 |
| Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer. | Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer.
Zhang J, Yang J, Lin C, Liu W, Huo Y, Yang M, Jiang SH, Sun Y, Hua R., Free PMC Article | 05/8/2021 |
| Non-native proteins inhibit the ER oxidoreductin 1 (Ero1)-protein disulfide-isomerase relay when protein folding capacity is exceeded. | Non-native proteins inhibit the ER oxidoreductin 1 (Ero1)-protein disulfide-isomerase relay when protein folding capacity is exceeded.
Moilanen A, Ruddock LW., Free PMC Article | 01/16/2021 |
| ERO1-Lalpha promotes hepatocellular carcinoma metastasis and angiogenesis through the S1PR1/STAT3/VEGF-A pathway. | Endoplasmic reticulum resident oxidase ERO1-Lalpha promotes hepatocellular carcinoma metastasis and angiogenesis through the S1PR1/STAT3/VEGF-A pathway.
Yang S, Yang C, Yu F, Ding W, Hu Y, Cheng F, Zhang F, Guan B, Wang X, Lu L, Rao J., Free PMC Article | 12/14/2019 |
| Data found that ERO1alpha expression increased under chronic hypoxia. Our results show that ERO1alpha was hypoxia-induced in all the tested cancer cell lines. | ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines.
Takei N, Yoneda A, Kosaka M, Sakai-Sawada K, Tamura Y., Free PMC Article | 11/30/2019 |
| Mechanism analysis suggested that ERO1L promoted many tumor-associated signaling pathways, especially the Wnt/catenin pathway; it could activate the Wnt/catenin pathway and upregulate the targets of the Wnt/catenin pathway. | ERO1L promotes pancreatic cancer cell progression through activating the Wnt/catenin pathway.
Han F, Xu Q, Zhao J, Xiong P, Liu J. | 10/12/2019 |
| Mutation of Val101 of Ero1 alpha results in a reduced Endoplasmic reticulum , retarded oxidative protein folding and decreased H2O2 levels in the Endoplasmic reticulum of cervical cancer cells and further impairs cell migration, invasion, and tumor growth. | Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1α and protein disulfide isomerase suppresses the progression of cervical cancer.
Zhang Y, Li T, Zhang L, Shangguan F, Shi G, Wu X, Cui Y, Wang X, Wang X, Liu Y, Lu B, Wei T, Wang CC, Wang L., Free PMC Article | 07/13/2019 |
| this study involving a gene-modification approach indicate that ERO1alpha is a major proliferation-enhancing factor in cancer cells and could be used as both a diagnostic biomarker of cancer exacerbation and a therapeutic target. | Hypoxia-inducible ERO1α promotes cancer progression through modulation of integrin-β1 modification and signalling in HCT116 colorectal cancer cells.
Takei N, Yoneda A, Sakai-Sawada K, Kosaka M, Minomi K, Tamura Y., Free PMC Article | 04/13/2019 |
| The authors show that endoplasmic reticulum oxidoreductin 1alpha (Ero1alpha), the pivotal sulfhydryl oxidase that catalyzes disulfide formation in the endoplasmic reticulum, is phosphorylated by Fam20C in the Golgi apparatus and retrograde-transported to the endoplasmic reticulum mediated by ERp44. | Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1α.
Zhang J, Zhu Q, Wang X, Yu J, Chen X, Wang J, Wang X, Xiao J, Wang CC, Wang L., Free PMC Article | 03/30/2019 |